Reproductive outcome in 326 women with unicornuate uterus

Tellum, Tina; Bracco, B; Braud, Lucrezia V. De; Knez, Jure; Ashton-Barnett, R; Amin, T.; Chaggar, P.

doi:10.1002/uog.26073

Cited by 11 publications

(5 citation statements)

References 46 publications

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“…Studies also indicate a higher risk of developing pelvic endometriosis in women with a unicornuate uterus with a residual horn compared to women with a uterus without a functional horn. In the given research groups, there were no differences in the incidence of adenomyosis, although it occurs much more often in patients with a unicornuate uterus compared to women with a properly shaped uterus [12].…”

Section: Unicornuate Uterusmentioning

confidence: 78%

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Congenital malformations of the female genital organs

Klimanek,

Drosdzol-Cop

2024

Ginekol Pol

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Section: Unicornuate Uterusmentioning

confidence: 78%

“…The procedure reduces the risk of an ectopic pregnancy developing first in the residual horn, which can lead to rupture and life-threatening hemorrhage. A reduced risk of developing adenomyosis after the procedure [12] has also been proven.…”

Section: Treatmentmentioning

confidence: 90%

Congenital malformations of the female genital organs

Klimanek,

Drosdzol-Cop

2024

Ginekol Pol

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“…Existing literature suggests that pregnancy outcomes for women with a unicornuate uterus are relatively unfavorable compared to those with a normal uterus [ 8 ]. As far as we know, this is the first case of pregnancy through IVF following treatment of NCRHP.…”

Section: Discussionmentioning

confidence: 99%

“…Pregnancies in women with a unicornuate uterus are recognized as high-risk due to an increased likelihood of preterm births. A recent study comparing women with a unicornuate uterus to a control group matched for BMI and age found increased rates of both miscarriage and preterm delivery, with an adjusted odds (aOR) ratio of 3.04 [ 8 ]. The underlying factor for these adverse outcomes is believed to be the relatively limited size of the unicornuate uterus, leading to insufficient expansion during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Successful pregnancy outcome via in-vitro fertilization and laparoscopic resection of non-communicating rudimentary horn pregnancy containing early pregnancy: a case report

Shin,

Kwon,

Kim

et al. 2024

BMC Pregnancy Childbirth

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Background Non-communicating rudimentary horn pregnancy (NCRHP) lead to life-threatening condition for both mother and fetus. Early diagnosis of NCRHP and laparoscopic resection is important to prevent catastrophic conditions. However, delayed diagnosis until the second or third trimester makes it difficult to accurately diagnose between NCRHP and bicornuate uterine pregnancy, as both conditions present uterine rupture and massive hemoperitoneum. Furthermore, these rare cases are challenging in pregnancy trials and associated with adverse outcomes in subsequent pregnancies. Case presentation A 31-year-old gravida 1 para 0 Korean woman visited our infertility center with a confirmed positive urine pregnancy test after timed intercourse. Before she was scheduled to have timed intercourse, a unicornuate uterus with a non-communicating right uterine horn was suspected based on an ultrasound scan and hysterosalpingography during the initial infertility workup. A gestational sac was observed in the right non-communicating rudimentary horn at 5 weeks of gestation. Serum beta-human chorionic gonadotropin (b-hCG) level was 2052.0mIU/mL. An elective laparoscopic resection of the right rudimentary horn containing a gestational sac, along with ipsilateral salpingectomy, was performed with no adverse event. After 3-month of recovery period and three cycles of conceptional trials involving timed intercourse and intrauterine insemination, in-vitro fertilization (IVF) was performed using the antagonist protocol, and successful pregnancy was confirmed. The patient had been hospitalized from 21 + 6 weeks to 35 + 6 weeks of gestation, underwent cerclage placement and tocolytics with corticosteroid treatment. She delivered an early-term male baby by cesarean section. Conclusion In this rare case, the successful pregnancy achieved through IVF following the appropriate management of NCRHP under laparoscopy underscores the critical importance of early diagnosis and intervention in cases of NCRHP. Timely identification and management of NCRHP are vital to prevent the occurrence of catastrophic conditions and to enhance the prognosis of a successful pregnancy through assisted reproductive technology (ART). Therefore, a high index of suspicion for NCRHP is important and employs a range of diagnostic modalities.

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“…Comparing our case to similar case reports, several common challenges and risks associated with unicornuate pregnancies emerge. Fetal growth restriction and preterm labor are frequently encountered in pregnancies with a unicornuate uterus [6][7][8]. These risks are attributed to the limited uterine expansion capacity and the developing fetus' altered blood supply.…”

Section: Discussionmentioning

confidence: 99%

Unicornuate Uterus with a Non-Communicating Rudimentary Horn: Challenges and Management of a Rare Pregnancy

Garapati,

Jajoo,

Sharma

et al. 2023

Cureus

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We present a unique case of pregnancy developed in a unicornuate uterus with a non-communicating rudimentary horn, emphasizing the importance of early identification, careful management, and counseling. Our patient, a 28-year-old woman, presented with abdominal pain and premature rupture of membranes at 37 weeks of gestation. She had a history of one previous normal vaginal delivery and no significant medical or genetic factors. An emergency cesarean section was performed, and a baby boy weighing 2900 grams was delivered without complications. The uterine anomaly was identified as a unicornuate uterus with a non-communicating rudimentary horn. This case report highlights the challenges and risks associated with unicornuate pregnancies, such as fetal growth restriction and preterm labor. Timely identification, meticulous monitoring, and comprehensive counseling are crucial for optimal outcomes in such cases. Further research and larger-scale studies are needed to enhance our understanding of these rare and complex pregnancies.

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Reproductive outcome in 326 women with unicornuate uterus

Cited by 11 publications

References 46 publications

Congenital malformations of the female genital organs

Congenital malformations of the female genital organs

Successful pregnancy outcome via in-vitro fertilization and laparoscopic resection of non-communicating rudimentary horn pregnancy containing early pregnancy: a case report

Unicornuate Uterus with a Non-Communicating Rudimentary Horn: Challenges and Management of a Rare Pregnancy

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