Reproductive outcomes and Y chromosome instability in radiation‐exposed male workers in cardiac catheterization laboratory

Abstract

Occupational radiation exposure may impact the reproductive outcome of male workers in the cardiac catheterization laboratory (cath Lab) who receive a dose of ~1–10 mSv/year. An increased copy number variation (CNV) in azoospermia factor region c (AZFc) of the Y chromosome is a marker of spermatogenic failure, previously associated with radiation exposure. This study sought to investigate the association between paternal exposure in the Cath Lab and adverse reproductive outcomes as well as to assess the induction of CNV in the AZFc region. In a case–control study, we enrolled 193 catheterization lab workers (Group I) and 164 age‐matched unexposed controls (Group II). Reproductive outcomes were assessed through a structured questionnaire. Two sequence‐tagged sites (SY1197 and SY579) in AZFc region were evaluated by qRT‐PCR in 83 exposed and 47 unexposed subjects. Exposed workers had a higher prevalence of low birth weight in offspring (Group I = 13% vs. II = 5.3%, P = 0.02; ORadjusted = 2.7; 95% CI: 1.1–6.3; P = 0.02). The mean of CNV (microdeletion and microduplication) for SY1197 was significantly higher in the exposed workers (Group I = 1.53 ± 0.85 vs. Group II = 1.02 ± 0.41; P = 0.0005). Despite the study design limitations, our findings show that chronic occupational radiation exposure of male workers is correlated with higher prevalence of low birth weight in offspring and instability in the Y chromosome AZFc region. Environ. Mol. Mutagen. 61:361–368, 2020. © 2019 Wiley Periodicals, Inc.

Anthropometric measurements in newborn children of personnel employed at radiation-hazardous production as indicators used in monitoring over consequences of parental exposure to radiation Primary tabs View(active tab) Edit

“…Similar trends were described by M.G. Andreassi with colleagues [7] when they assessed influence exerted by occupational exposure on reproductive outcomes among personnel working at a heart catheterization laboratory and exposed to an annual dose equal to 1-10 mSv/year. They showed that chronic occupational exposure of male workers correlated with higher prevalence of low birthweight among their offspring (OR = 2.7, CI 1.1-6.3).…”

Biomarkers of Genotoxicity in Medical Workers Exposed to Low-Dose Ionizing Radiation: Systematic Review and Meta-Analyses

“…The latter exposure parameter takes into account the number of years in catheterization laboratory, the number of procedures per year, and the distance from the source of radiation. Recently, using quantitative real-time PCR, a significantly higher rate of microdeletion and microduplication as assessed by copy number variation (CNV) in the SY1197 sequence-tagged site of the Y-chromosome azoospermia factor region c (AZFc) was shown in male Cath lab workers compared to unexposed controls (CNV = 1.53 ± 0.8 vs. CNV = 1.02 ± 0.4 respectively, p = 0.0005) [ 29 ]. However, a non-significant difference was shown for the SY579 site CNV in AZFc region between exposed and unexposed workers.…”

Low-dose ionizing radiation and adverse birth outcomes: a systematic review and meta-analysis

“…There were six studies that investigated occupational exposure from medical ( n = 3) (Andreassi et al 2020 ; Fucic et al 2008 ; Lawson et al 2012 ), nuclear ( n = 2) (Doyle et al 2000 ; Parker et al 1999 ), and flight attendant ( n = 1) (Grajewski et al 2015 ) sectors. A total of 14 studies examined medical exposures for diagnostic ( n = 6) (Chen et al 2018 ; Choi et al 2013 ; Goldberg et al 1997 ; Guilbaud et al 2019 ; Hujoel et al 2004 ; Mortazavi et al 2013 ) or therapeutic ( n = 8) (Chiarelli et al 2000 ; Green et al 2010 ; Green et al 2002 ; Källén et al 1998 ; Reulen et al 2009 ; Signorello et al 2006 ; van de Loo et al 2019 ; Winther et al 2008 ) purposes.…”