Reproductive disorders are one of the most important problems that affect the production and productivity of dairy cows. The study which employed both questionnaire and regular follow up was conducted in Dessie and Kombolcha with the objectives of determining the prevalence of major reproductive health problems of dairy cattle and to asses possible risk factors and to forward the possible recommendations to the prevention and control approaches in 22 dairy farms from November 2015 to May 2016. A total of 487 dairy cattle 456(93.6%) cross and 31 (6.4%) local breed which were kept under different management system 444 (91.2%) intensive and 43(8.8%) semi intensive were included, out of which 39.8% (n=194) had at least one of the reproductive disorders. Repeat breeder, Retained Fetal membrane (RFM), anestrous, and dystocia were found to be the major reproductive health problems containing 9.9%, 7.6%, 5.3% and 4.5% prevalence rate respectively and other reproductive health problems observed with lower prevalence include mixed, vaginal prolapsed, abortion and uterine prolapsed having 4.1%, 3.3%, 3.1%, and 2.1% prevalence rate respectively in the study farms of the two towns. The prevalence of reproductive problems showed significant difference (p<0.05) with respect to age, BCS and parity of dairy cows Whereas, breed, management system and place of farm were not found to have a significant influence (p>0.05) on the occurrence of reproductive problems in dairy cows where major reproductive health problems were observed in cross breed and intensive production system as well as in Kombolcha dairy farms. Therefore, it is recommended that awareness creation to farm owners, attendants and improved management such as, proper feeding, accurate heat detection, considering the size of sire and dam while using AI, and health management should be improved to minimize the occurrence of these problems and associated economic losses in the dairy farms of the area