Reproductive Performance of Ewes after 5‐Day Treatment with Intravaginal Inserts Containing Progesterone in Combination with Injection of Prostaglandin F<sub>2</sub><i>α</i>

Dixon, A.B.; Knights, M.; Pate, J. L.; Lewis, P. E.; Inskeep, E. K.

doi:10.1111/j.1439-0531.2006.00656.x

Cited by 41 publications

(45 citation statements)

References 54 publications

(82 reference statements)

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“…In the Chronogest ® CR group only one ewe lost the sponge whereas in ewes with Eazi-breed™ CIDR ® G no inserts were lost resulting in retention rates of 99.3 and 100%, respectively. Similar values, ranging from 97.3 to 100%, were reported in earlier studies (Dixon et al, 2006;Knights et al, 2001) using the CIDR device. Although the inserts were left in place only for 6 days all ewes treated with Chronogest ® CR showed malodorous mucosal vaginal discharge at device removal.…”

Section: Discussionsupporting

confidence: 75%

“…Lambing rate to first service period and overall as well as overall litter size were higher in this study compared to previous studies (Dixon et al, 2006;Knights et al, 2001). As lambing rate and litter size are strongly influenced by the breed the highly prolific Red Engadine ewes in flock A might have improved the values.…”

Section: Discussioncontrasting

confidence: 54%

“…When comparing the percentage of ewes that lambed to first service period in this study (48.3% for Eazi-breed™ CIDR ® G and 51.4% for Chronogest ® CR) with other investigations using short-term protocols, values were higher (Knights et al 2001, 46%), but lower than reported by Dixon et al (2006) (56.6% and 59.5%) and Viñoles et al (2001) (58% and 87%). However, comparing fertility results of the different studies is difficult, because various breeds with differing prolificacy were used in the experiments carried out in season (Dixon et al, 2006;Viñoles et al, 2001) or out-ofseason (Knights et al, 2001) using nulli-and pluriparous ewes.…”

Section: Discussioncontrasting

confidence: 46%

“…However, comparing fertility results of the different studies is difficult, because various breeds with differing prolificacy were used in the experiments carried out in season (Dixon et al, 2006;Viñoles et al, 2001) or out-ofseason (Knights et al, 2001) using nulli-and pluriparous ewes.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, progestagen treatment is also known to impair sperm transport and survival reducing the number of fertilized ova (Allison and Robinson, 1970;Hawk and Conley, 1972). To overcome these problems progestagen administration can be shortened to 5-6 days in combination with injection of prostaglandin F2α at the time of insert removal (Dixon et al, 2006;Knights et al, 2001;Ungerfeld and Rubianes, 1999;Viñoles et al, 2001). In the 1980s the CIDR (controlled intravaginal drug release) progesterone device was designed in New Zealand for estrus synchronization in sheep and goats (Welch et al, 1984) and is now approved (Eazi-breed™ CIDR ® G, Pfizer Animal Health) in New Zealand, Australia, USA, Canada and in different countries in South America but is not anymore available in Europe.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of 6-day progestagen treatment with Chronogest® CR and Eazi-breed™ CIDR® G intravaginal inserts for estrus synchronization in cyclic ewes

Fleisch¹,

Werne²,

Heckendorn³

et al. 2012

Small Ruminant Research

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The aim of this study was to compare the efficacy of two different short-term progestagen treatments for estrus synchronization in cyclic ewes. A total of 292 ewes of 3 flocks (A-C) on different farms were treated for 6 days with Eazi-breed™ CIDR® G (n = 145) or Chronogest® CR (n = 147) vaginal inserts in combination with 0.125 mg Cloprostenol and 300IU eCG at device removal. Blood samples were taken for progesterone (P4) determination at insert application and removal as well as 14 days later. One day after insert removal rams fitted with marking harnesses were joined to ewes for 35 days and marked ewes recorded daily. Lambing data were recorded and fertility to first service period and overall assessed. Results show that 24-96 h after insert removal 98.8% and 89.4% of the synchronized ewes in the flocks B and C were in estrus. Estrus response was not affected by the type of progestagen treatment and was lower (P < 0.05) in nulli-(82.1%) than in pluriparous (97.5%) ewes. Type of progestagen treatment did not affect fertility, but flock and parity influenced the percentage of ewes that lambed as well as the lambing rate. Overall more ewes (P < 0.001) lambed in flock A compared to flocks B and C (93.0 vs. 72.5 and 59.1%). In nulliparous animals the percentage of ewes that lambed was higher to the first service (P < 0.05) period but lower (P < 0.001) to the overall service period compared to pluriparous animals (51.5% vs. 49.3% and 64.7% vs. 84.2%). Lambing rates were higher in flock A than in flocks B and C to first service period and overall (1.3 ± 1.4, 0.9 ± 1.0, and 0.7 ± 1.0, P < 0.01 and 1.9 ± 1.1, 1.3 ± 0.9, and 1.0 ± 1.0, P < 0.001) and in nulliparous overall lower than in pluriparous ewes (1.1 ± 1.1 and 1.6 ± 1.1, P < 0.01). Serum P4 concentrations measured 14 days after insert removal were higher in the Chronogest® CR than in the Eazi-breed™ CIDR® G group (6.8 ± 4.1 ng/mL vs. 5.7 ± 3.3 ng/mL). Ewes of flock A had higher P4 values compared to ewes of flocks B and C (8.3 ± 4.1 ng/mL vs. 4.5 ± 1.5 ng/mL and 3.8 ± 1.7 ng/mL) and nulliparous lower P4 concentrations than pluriparous ewes (4.5 ± 2.2 ng/mL vs. 6.7 ± 4.0 ng/mL). In conclusion, a 6-day treatment with Chronogest® CR and Eazi-breed™ CIDR® G with prostaglandin and eCG at insert removal resulted in high estrus response and similar fertility in cyclic ewes. AbstractThe aim of this study was to compare the efficacy of two different short-term progestagen treatments for estrus synchronization in cyclic ewes. A total of 292 ewes 72.5 and 59.1%). In nulliparous animals the percentage of ewes that lambed was higher to the first service (P<0.05) period but lower (P<0.001) to the overall service period compared to pluriparous animals (51.5 vs. 49.3% and 64.7 vs. 84.2%).Lambing rates were higher in flock A than in flocks B and C to first service period and overall (1.3±1.4, 0.9±1.0, 0.7±1.0, P<0.01 and 1.9±1

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Section: Discussionsupporting

confidence: 75%

Section: Discussioncontrasting

confidence: 54%

Section: Discussioncontrasting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of 6-day progestagen treatment with Chronogest® CR and Eazi-breed™ CIDR® G intravaginal inserts for estrus synchronization in cyclic ewes

Fleisch¹,

Werne²,

Heckendorn³

et al. 2012

Small Ruminant Research

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Estrus synchronization in sheep with synthetic progestagens

Awel

Eshetu

Tadesse

et al. 2009

Trop Anim Health Prod

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Sixteen female sheep of Degua breed were assigned to receive either the full dose of norgestomet ear implant and injectable solution containing norgestomet and estradiol valerate (n = 8) or half the dose (n = 8). The ear implants were removed in both groups on day 12. All ewes received an intramuscular administration of 500 IU PMSG at implant withdrawal. Synchronized ewes were individually hand mated twice at 48 and 60 hours after implant removal. One ewe in each group however refused mating on both occasions. Pregnancy diagnosis was conducted by bimanual external palpation 90 to 100 days post mating. The conception rates (3/7, 42.85%) and (5/7, 71.42%) were recorded in the two treatment groups, respectively. All eight ewes lambed between 145 to 153 days post mating. In group I ewes carried only singletons (prolificity rate 1.0) whereas in group II two ewes delivered twins, producing 7 lambs with prolificity rate of 1.4 (N.S). From this preliminary investigation it appears that the lower dose of norgestomet ear implants offers better option for estrus synchronization accompanied by higher fertility.

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Reproductive performance in out-of-breeding season of fatty ewes using implant norgestomet with or without PMSG

Garoussi

Farzaneh

Gallehdar

et al. 2011

Trop Anim Health Prod

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Pregnancy in out-of-breeding season in ewes increases the economical goals. Synchronization of estrus and ovulation is essential for above program. The aims of this study using implant norgestomet with or without Pregnant Mare Serum Gonadotropin (PMSG) were to evaluate the serum progesterone (P4) concentration changes: the conception rate and estimation of the lambing rate and litter size. In total, 80 non-cycling multiparous Iranian Kurdish breed fat-tailed ewes with <0/5 ng/ml P4 were used in April and May 2008 in the suburb of Mashhad, Iran. The animals were randomly divided into three groups: a control group (n = 30) without hormonal treatment, another group (n = 25) received 3 mg of norgestomet implant placed subcutaneously in the convex surface of the ear for 9 days, and the third group (n = 25) treated with 3 mg of norgestomet implant for 9 days with an IM injection of 500 IU PMSG at implant removal. The progesterone of treatment and control groups were measured on days 4, 9, and 13 after removal of the norgestomet using radioimmunoassay. Every five ewes were exposed to one ram after 24 h of norgestomet removal in treatment and control groups, simultaneously. The pregnancy was examined after 25 days of ram removal using ultrasonography. Progesterone concentration was significantly higher in treatment groups on 9 and 13 days after norgestomet removal (P < 0.05). The pregnancy rate in the control, non-PMSG, and PMSG treatments groups were 17%, 52%, and 72%, respectively. The rates of single and twin pregnancy in the non-PMSG treatment group were 69% and 31%, respectively. These rates in norgestomet and PMSG treatment group were 50% and 39%, respectively. Triplet pregnancy (11%) was observed only in the PMSG treatment group. It was concluded that using implant norgestomet especially accompanied with PMSG can increase and improve the fertilization rate of ewe in the out-of-breeding season program.

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Reproductive Performance of Ewes after 5‐Day Treatment with Intravaginal Inserts Containing Progesterone in Combination with Injection of Prostaglandin F₂α

Cited by 41 publications

References 54 publications

Comparison of 6-day progestagen treatment with Chronogest® CR and Eazi-breed™ CIDR® G intravaginal inserts for estrus synchronization in cyclic ewes

Comparison of 6-day progestagen treatment with Chronogest® CR and Eazi-breed™ CIDR® G intravaginal inserts for estrus synchronization in cyclic ewes

Estrus synchronization in sheep with synthetic progestagens

Reproductive performance in out-of-breeding season of fatty ewes using implant norgestomet with or without PMSG

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Reproductive Performance of Ewes after 5‐Day Treatment with Intravaginal Inserts Containing Progesterone in Combination with Injection of Prostaglandin F2α

Cited by 41 publications

References 54 publications

Comparison of 6-day progestagen treatment with Chronogest® CR and Eazi-breed™ CIDR® G intravaginal inserts for estrus synchronization in cyclic ewes

Comparison of 6-day progestagen treatment with Chronogest® CR and Eazi-breed™ CIDR® G intravaginal inserts for estrus synchronization in cyclic ewes

Estrus synchronization in sheep with synthetic progestagens

Reproductive performance in out-of-breeding season of fatty ewes using implant norgestomet with or without PMSG

Contact Info

Product

Resources

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Reproductive Performance of Ewes after 5‐Day Treatment with Intravaginal Inserts Containing Progesterone in Combination with Injection of Prostaglandin F₂α