Reproductive Performance of Patients Treated With Clomiphene Citrate

Wc, Nunley; Bg, Bateman; Jd, Kitchin

doi:10.1097/00007611-198501000-00008

Cited by 7 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No clear associations have been made between adverse pregnancy outcomes and the use of chlomiphene citrate (Clomid®). Only two of seven papers reviewed 17 had control groups, of which one showed a non‐significant positive association with perinatal mortality, 18 and the second showed a non–significant inverse association with stillbirths 19 . Multifetal gestations are linked with chlomiphene citrate; 17 this was controlled in our analyses.…”

Section: Discussionmentioning

confidence: 99%

Risk of stillbirth from medications, illnesses and medical procedures

Pastore

Hertz‐Picciotto

Beaumont

1999

Paediatric Perinatal Epid

View full text Add to dashboard Cite

Associations between stillbirth and 14 medical exposures during pregnancy were examined using deliveries in 1984 in 10 California counties. Cases (n = 332) were stillbirths and infant deaths within 24 h of birth. Randomly selected live births served as controls (n = 357) and were frequency matched by maternal age and county. Using questionnaire and vital statistics data, logistic regression and proportional hazards modelling were performed with adjustment for potential confounders. The most prevalent exposures were ultrasound (65% of cases, 58% of controls) and acetaminophen (45% of cases, 54% of controls). Prescription pain medication, when taken in the first 2 gestational months, was strongly associated with stillbirths due to congenital anomalies (odds ratio = 7.5, 95% confidence interval [CI] 2.3, 24.1). First and second trimester use of prescription pain or migraine medication was positively associated with all stillbirths (rate ratio [RR] range 1.3-1.6). Fertility drugs were positively associated with stillbirths in total and stillbirths due to complications of the placenta, cord and membranes (RR = 1.8, 95% CI 0.8, 4.1; and RR = 2.5, 95% CI 0.9, 7.2 respectively). No associations were found for aspirin, amniocentesis, diagnostic X-rays or fever, consistent with previous studies. This report is among the few studies of specific causes of stillbirth and medical exposures by gestational time window.

show abstract

Section: Discussionmentioning

confidence: 99%

Risk of stillbirth from medications, illnesses and medical procedures

Pastore

Hertz‐Picciotto

Beaumont

1999

Paediatric Perinatal Epid

View full text Add to dashboard Cite

show abstract

“…Two studies report abortion rates in women with ovulation disorders who failed to conceive with clomiphene treatment, but who conceived later with spontaneous ovulation after clomiphene treatment was discontinued. One study (37) reported 25.3% spontaneous abortion in the treated group compared with 10% in those conceiving spontaneously and another study (34) showed rates of approximately 15% in both groups. Small study sizes limited the findings of both studies.…”

Section: Spontaneous Abortionmentioning

confidence: 99%

“…Hospital based case-series report a multiple pregnancy incidence of between 4.4-13%. One study (34) found no multiple pregnancies in women who failed to conceive with clomiphene treatment but who did become pregnant later after spontaneous ovulation.…”

Section: Multiple Pregnancymentioning

confidence: 99%

Clomiphene Citrate and Pregnancy Outcome

Venn

Lumley

1994

Aust NZ J Obst Gynaeco

View full text Add to dashboard Cite

Data from Australia and elsewhere have shown consistently that adverse perinatal outcomes such as preterm birth and perinatal mortality are more common in pregnancies resulting from assisted conception with IVF and GIFT than normally conceived pregnancies. Factors that may contribute to the excess of poor outcomes include maternal factors, the assisted conception procedures themselves and possibly the influence of drugs used to induce superovulation. This review examines the medical literature describing pregnancies following ovulation induction with one of the drugs used to induce superovulation, clomiphene citrate, and compares their outcomes with Australian IVF and GIFT pregnancy outcomes. The review shows that whilst some studies have suggested higher rates of ectopic pregnancy, spontaneous abortion and congenital malformations in clomiphene citrate induced pregnancies, the findings are inconsistent and the data are flawed. There are only very poor data available on the incidence of preterm birth. Multiple pregnancy is a well-recognized adverse outcome of clomiphene citrate induced pregnancies. Attempts to improve perinatal outcomes of pregnancies following assisted conception will be helped by a better understanding of the relative contributions of maternal and treatment factors and further studies of pregnancy outcome after ovulation induction are needed.

show abstract