Reproductive potential of azoospermic men undergoing intracytoplasmic sperm injection is dependent on the type of azoospermia

Prudencio, C.; Seol, Bill; Esteves, Sandro C.

doi:10.1016/j.fertnstert.2010.07.903

Cited by 13 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ICSI is associated with lower fertilization rates per injected oocyte, as well as, clinical pregnancy and delivery rates when testicular spermatozoa from men with non-obstructive azoospermia are used in comparison with epididymal/testicular sperm from men with obstructive azoospermia [61]. Such differences may be explained by the fact that testicular spermatozoa from men with severely impaired spermatogenesis have a higher tendency to carry deficiencies such as the ones related to the centrioles and genetic material, which ultimately affect the capability of the male gamete to activate the egg and trigger the formation and development of a normal zygote and a viable embryo [62].…”

Section: The Role Of Varicocele In Male Infertilitymentioning

confidence: 99%

What every gynecologist should know about male infertility: an update

Esteves¹,

Hamada

Kondray

et al. 2012

Arch Gynecol Obstet

View full text Add to dashboard Cite

Extraordinary advances have been achieved in the field of male infertility over the past several years and many old concepts are now challenged. Therefore, it is imperative that male infertility physicians should update the gynecologists about the recent advances in the work-up of infertile men in terms of diagnosis and management. Such convention will help improve the standards of care for the infertile couple and enhance the cooperation between male and female reproductive endocrinologists.

show abstract

Section: The Role Of Varicocele In Male Infertilitymentioning

confidence: 99%

What every gynecologist should know about male infertility: an update

Esteves¹,

Hamada

Kondray

et al. 2012

Arch Gynecol Obstet

View full text Add to dashboard Cite

show abstract

“…[39] Clinical pregnancy and live birth rates are also lower in NOA than other male infertility scenarios. [395253] In one report comparing the reproductive potential of azoospermic men undergoing SR and ICSI, the likelihood of obtaining a live birth was 1.8-fold higher (odds ratio [OR] = 1.86; 95% CI: 1.03-2.89) in men with OA compared with men with NOA. [52] These findings indicate that men with NOA undergoing ART have decreased reproductive potential, which may be explained by a higher tendency of their testicular sperm to carry deficiencies related to the centrioles and genetic material.…”

Section: Discussionmentioning

confidence: 99%

Micro-dissection testicular sperm extraction as an alternative for sperm acquisition in the most difficult cases of Azoospermia: Technique and preliminary results in India

Ashraf¹,

Singh²,

Raj³

et al. 2013

J Hum Reprod Sci

View full text Add to dashboard Cite

CONTEXT:Non-obstructive azoospermia (NOA) is an unfavorable prognostic condition for male infertility since spermatogenesis is disrupted. Sperm retrieval (SR) coupled with intracytoplasmic sperm injection (ICSI) is the only option for men with NOA who seek fertility. Among the SR techniques, microdissection testicular sperm extraction (micro-TESE) has been applied with encouraging results.AIMS:We describe how we implemented the micro-TESE procedure and present initial micro-TESE experience in a group of men with NOA and poor prognosis for SR.SETTINGS AND DESIGN:Case series of men with NOA treated in a tertiary healthcare center.MATERIALS AND METHODS:An Assisted Reproductive Technology (ART) facility was setup to perform SR using microsurgery. Fourteen men with NOA and previous failed retrievals or unfavorable histologic results underwent micro-TESE while their female partners received ovarian stimulation for oocyte pickup (OCP). Micro-TESE was performed the day prior to OCP and testicular sperm were used for sperm injections. We assessed retrieval rates and ICSI outcomes.STATISTICAL ANALYSIS:Outcomes of SR and ICSI were analyzed descriptively. Mann-Whitney and Fisher exact test were used to compare characteristics of men with successful and failed SR.RESULTS:The success of micro-TESE was 50.0% with no major complications. A clear microscopic distinction between enlarged and collapsed seminiferous tubules was seen in 35.7% of the cases, and sperm were retrieved in all but one of these cases. Patients with successful and failed retrieval did not differ with respect to baseline characteristics, use of medical therapy, presence of varicocele, and testicular histology. Sperm injections resulted in normal fertilization and embryo cleavage of 64% and 75%, respectively. A total of five transfers with an average of 1.5 embryos resulted in a cumulative clinical pregnancy rate per ICSI cycle of 28.6%, with an implantation rate of 33.3%.CONCLUSIONS:We were successful in integrating the micro-TESE procedures to the in vitro fertilization (IVF) laboratory. Our initial experience with micro-TESE applied to the most difficult cases of azoospermia is reassuring.

show abstract

“…ICSI is associated with lower fertilization rates per injected oocyte as well as clinical pregnancy and delivery rates when testicular spermatozoa from men with NOA are used in comparison to epididymal/testicular sperm from men with OA [113][114][115]. Once a live birth is achieved, newborn parameters of infants conceived were not significantly different among the groups, and no major differences are noted in the offspring's neonatal profile [113].…”

Section: Azoospermiamentioning

confidence: 97%

Engaging Practicing Gynecologists in the Management of Infertile Men

Agarwal

Hamada

Esteves³

2014

J Obstet Gynecol India

View full text Add to dashboard Cite

In the modern era, contemporary management of male infertility has undergone groundbreaking changes with the introduction of new concepts, advanced testing, and therapeutic interventions. As practicing gynecologists are often the first physicians who encounter an infertile couple, it is essential that these clinicians are continuously updated about the new pearls and pitfalls of male infertility management. Semen analysis is commonly ordered by gynecologists. In 2010, the WHO released new cutoff reference values for the semen parameters adopting novel methodology, which has incited much debate. Reference values have been lowered in comparison with previous standards, with a direct clinical implication in decision-making strategies. Specialized sperm-function tests, such as sperm oxidative stress and sperm chromatin integrity assessments, became clinically available, thus offering an opportunity to better understand sperm dysfunctions concealed during routine semen analysis. Furthermore, the initial counseling of azoospermic men by an andrologically well educated gynecologist may alleviate the misconception and distress surrounding the false belief of sterility, and will clarify the 123 available options of percutaneous and microsurgical spermretrieval techniques and assisted conception outcome. Regarding varicocele, which is commonly seen in infertile males, it is now clear that the best treatment option for infertile men with clinical varicocele is the microsurgical vein ligation. Natural conception is significantly improved after varicocelectomy, and recent data suggest that such treatment optimizes reproductive outcome of couples undergoing ICSI or micro-TESE sperm retrieval. Lastly, new therapeutic interventions, including oral antioxidant therapy and lifestyle modifications, have gained increasing attention, as they aid in alleviating male infertility.

show abstract

Reproductive potential of azoospermic men undergoing intracytoplasmic sperm injection is dependent on the type of azoospermia

Cited by 13 publications

References 0 publications

What every gynecologist should know about male infertility: an update

What every gynecologist should know about male infertility: an update

Micro-dissection testicular sperm extraction as an alternative for sperm acquisition in the most difficult cases of Azoospermia: Technique and preliminary results in India

Engaging Practicing Gynecologists in the Management of Infertile Men

Contact Info

Product

Resources

About