Reproductive potential of mosquitofish is reduced by the masculinizing effect of a synthetic progesterone, gestodene: Evidence from morphology, courtship behaviour, ovary histology, sex hormones and gene expressions

Chen, Shanduo; Lin, Canyuan; Tan, Jiefeng; Wang, Yifan; Wang, Xiaoyun; Wang, Xiaolan; Liu, Lu; Li, Jiayi; Hou, Liping; Liu, Juan; Leung, Jonathan Y.S.

doi:10.1016/j.scitotenv.2020.144570

Cited by 16 publications

(2 citation statements)

References 53 publications

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“…In turquoise killifish, the sociability of the males exposed to fluoxetine was enhanced, contributing to the increase of mating frequency and reproductive output in fish populations [24]. Similarly, the male mosquitofish showed less intimacy and mating interest towards the gestodene-exposed females, indicating the time spent on attending, following, and mating behaviors decreased [25]. According to the above research, it is clear that the social interaction of female-male influences the mating behavior of fish.…”

Section: Introductionmentioning

confidence: 87%

Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish

Yan

Lü

et al. 2023

IJERPH

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The aim of this study was to explore the underlying mechanism of adverse effects caused by tebuconazole (TEB) on the reproduction of aquatic organisms In the present study, in order to explore the effects of TEB on reproduction, four-month-old zebrafish were exposed to TEB (0, DMSO, 0.4 mg/L, 0.8 mg/L, and 1.6 mg/L) for 21 days. After exposure, the accumulations of TEB in gonads were observed and the cumulative egg production was evidently decreased. The decline of fertilization rate in F1 embryos was also observed. Then the changes in sperm motility and histomorphology of gonads were discovered, evaluating that TEB had adverse effects on gonadal development. Additionally, we also found the alternations of social behavior, 17β-estradiol (E2) level, and testosterone (T) level. Furthermore, the expression levels of genes involved in the hypothalamic-pituitary-gonadal (HPG) axis and social behavior were remarkably altered. Taken together, it could be concluded that TEB affected the egg production and fertilization rate by interfering with gonadal development, sex hormone secretion, and social behavior, which were eventually attributed to the disruption of the expressions of genes associated with the HPG axis and social behavior. This study provides a new perspective to understanding the mechanism of TEB-induced reproductive toxicity.

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Section: Introductionmentioning

confidence: 87%

Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish

Yan

Lü

et al. 2023

IJERPH

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“…28 Paulos et al also found that the NET exposure to 1.2, 16.0 and 85.0 ng/L for 21 day led to the development of the male secondary sexual characteristics of a dark spot on the dorsal fin in females of fathead minnows. 27 Furthermore, masculinization of female fish exposed to other progestins, such as norgestrel and gestodene in western mosquitofish, 46,49 levonorgestrel, gestodene and desogestrel in fathead minnows 50 and levonorgestrel in fathead minnows and threespined stickleback (Gasterosteus aculeatus) were documented. 51,52 These results indicate that these progestins induce masculinization of female fish.…”

Section: Gonadal Histological Analysis Following Exposure To Netmentioning

confidence: 99%

Norethindrone alters growth, sex differentiation and gene expression in marine medaka (Oryzias melastigma)

Dong

Chen

et al. 2022

Environmental Toxicology

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Norethindrone (NET) is a widely used synthetic progestin, which appears in water environments and threatens aquatic organisms. In this study, marine medaka (Oryzias melastigma) larvae were exposed to 7.6 and 80.1 ng/L NET for 190 days. The effects of NET on growth, sex differentiation, gonad histology and transcriptional expression profiles of hypothalamic-pituitary-gonadal (HPG) axis-related genes were determined. The results showed that exposure to 80.1 ng/L NET caused an all-male marine medaka population and significantly decreased the growth of males. Exposure to 7.6 ng/L NET increased the ratio of males/females in the marine medaka population, decreased the growth of males and delayed the ovary maturation in females.However, the sperm maturation was accelerated by 7.6 or 80.1 ng/L NET. In females, the transcription levels of cytochrome P450 aromatase (cyp19a1a) and progesterone receptor (pgr) in ovaries, glucocorticoid receptor (gr) and vitellogenin (vtg) in livers were suppressed after exposure to 7.6 ng/L NET, which may cause delayed ovary maturation. In males, NET significantly decreased the transcription levels of follicle stimulating hormone β (fshβ) and Luteinizing hormone β (lhβ)in the brain, Estrogen receptor β (erβ)，gr and pgr in the liver, and vitellogenin receptor (vtgr) in the testes, while NET of 80.1 ng/L led to a significant up-regulation of steroidogenic acute regulatory protein (star) in the testes of males. These results showed that NET could influence growth, sex differentiation and gonadal maturation and significantly alter the transcriptional expression levels of HPG axis-related genes.

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The effect of cortisone on female zebrafish (Dania rerio): Reducing reproductive capacity and offspring survival rate

Ye,

Yang,

Cai

et al. 2024

Aquatic Toxicology

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Reproductive potential of mosquitofish is reduced by the masculinizing effect of a synthetic progesterone, gestodene: Evidence from morphology, courtship behaviour, ovary histology, sex hormones and gene expressions

Cited by 16 publications

References 53 publications

Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish

Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish

Norethindrone alters growth, sex differentiation and gene expression in marine medaka (Oryzias melastigma)

The effect of cortisone on female zebrafish (Dania rerio): Reducing reproductive capacity and offspring survival rate

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