Reproductive risk factor associations with lobular and ductal carcinoma in the Carolina Breast Cancer Study

Williams, Lindsay A.; Nichols, Hazel B.; Hoadley, Katherine A.; Tse, Chiu Kit; Geradts, Joseph; Bell, Michael; Perou, Charles M.; Love, Michael I.; Olshan, Andrew F.; Troester, Melissa A.

doi:10.1007/s10552-017-0977-9

Cited by 13 publications

(11 citation statements)

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“…We found an increased risk of both IDC and ILC subtypes in women who were older at their first delivery, which is in agreement with the findings of some previous studies, but not all . Another study suggested that there is no significant difference between the risk of breast cancer subtypes and reproductive factors including the age of first delivery …”

Section: Discussionsupporting

confidence: 92%

“…Ductal and lobular tumours are the two most frequently diagnosed subtypes of invasive breast carcinomas (75% and 15% of all malignant tumours, respectively), and these two subtypes have different clinical, molecular and pathologic features . However, only few epidemiological studies have examined the heterogeneity of the disease, and the differences in risk factors are not yet fully understood …”

Section: Introductionmentioning

confidence: 99%

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Heterogeneity in risk factors for ductal and lobular breast carcinomas: A case–control study

Dianatinasab

Fararouei

Daneshi³

et al. 2019

Intl Journal of Cancer

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Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) of the breast are the most common histological subtypes of breast cancer. However, the associations and heterogeneity between histological subtypes and their risk factors are not well established. This study aimed to investigate risk factors for IDC and ILC. This case-control study included 1,009 incident breast cancer cases and 1,009 hospital controls, frequency-matched by age. Data were obtained from the patients' medical files and an interview administered via a questionnaire. Multinomial logistic regression was used and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. The heterogeneity of the associations was assessed using the Wald test. Family history of breast cancer was associated with IDC (OR 2.64, 95% CI: 1.97-3.55) but not ILC (OR 0.81, 95% CI: 0.42-1.57; p for heterogeneity <0.001). Conversely, a history of miscarriage was associated with ILC (OR 1.71, 95% CI: 1.17-2.51) but not IDC (OR 1.18, 95% CI: 0.95-1.46; p for heterogeneity = 0.04). Similarly, type 2 diabetes was associated with ILC but not IDC (p for heterogeneity = 0.02). Age at first delivery and breastfeeding were significantly associated with IDC but not ILC, though p values for heterogeneity did not reach the significance level. Deliberate weight loss and age at menarche were significantly associated with ILC but not IDC (p for heterogeneity ≥0.27). Smoking, history of benign breast disease and BMI were associated with both subtypes. The present study supports the hypothesis that IDC and ILC are etiologically distinct tumours. Cancer Epidemiologyheterogeneity of ductal and lobular breast carcinomas risk factors Int. J. Cancer: 145, 2917-2925 (2019) © 2019 UICC Cancer Epidemiology heterogeneity of ductal and lobular breast carcinomas risk factors Int.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Heterogeneity in risk factors for ductal and lobular breast carcinomas: A case–control study

Dianatinasab

Fararouei

Daneshi³

et al. 2019

Intl Journal of Cancer

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“…Breast cancer risk increases with later menopause [44]. Women who experience menopause at age 55 or older have about a 12% higher risk compared to those who do so between ages 50-54 [45,46]. In our study, we found no signi cant association between breast cancer risk and late menopauses.…”

Section: Discussioncontrasting

confidence: 70%

Investigation Risk Factors for Breast Cancer in Women: A Case–Control Study in Arak, Iran

Pezeshki

Ansari

Rezaie

et al. 2020

Preprint

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BackgroundBreast cancer is the most common malignant in women globally. In Iran, breast cancer incidence rate is continuously increasing. This study aimed to investigate the risk factors for breast cancer in Iranian women.MethodsA hospital-based case-control study was conducted between September 2016 and July 2019 in Arak, Iran. The sample size was 400 breast cancer patients and 400 healthy women. Demographical records and risk factor related data were collected. Logistic regression analysis used to calculate odds ratios (ORs) and 95% confidence intervals (CIs).ResultsData showed that among various factors, urban life (OR = 1.361, 95% CI 1.025–1.808, P = 0.033), height (OR = 3.347, 95% CI 2.0443–5.480, P = 0.000), BMI (OR = 0.397, 95% CI 0.273–0.577, P = 0.000), education level (OR = 7.048, 95% CI 3.985–12.467, P = 0.000), awareness level (OR = 0.507, 95% CI 0.349–0.736, P = 0.000), job status (OR = 0.321, 95% CI 0.122–0.846, P = 0.022), economic status (OR = 4.333, 95% CI 1.424–13.184, P = 0.010), early menarche (OR = 2.815, 95% CI 1.745–4.541, P = 0.000), Stillbirth status (OR = 1.935, 95% CI 1.087–3.446, P = 0.025), family history (OR = 10.281, 95% CI 3.628–29.134, P = 0.000), behavioral habits (OR = 0.554, 95% CI 0.386–0.796, P = 0.001), and second-hand smoking (OR = 1.472, 95% CI 1.108–1.955, P = 0.008) significantly were associated with an increased risk for breast cancer.ConclusionThe data suggest that lifestyle may have more impact on the incidence of breast cancer in Iranian women, suggesting change unhealthy lifestyle and screening for preventing breast cancer.

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“…Studies of adult neoplasms including breast (1)(2)(3)(4)(5), colon (6)(7)(8), and prostate (9,10), have shown that subtyping, whether molecular or histologic, leads to identification of etiologic heterogeneity between tumor subtypes that may inform targeted public health prevention strategies. For example, in breast cancer, there are robust findings across multiple study populations showing evidence of etiologic heterogeneity by reproductive risk factors such as age at menarche, first birth, and menopause, as well as combined menopausal hormone therapy use for lobular, compared with ductal carcino-ma, and by molecular breast cancer subtype (1)(2)(3)(4)(5). Similarly, there is etiologic variation by histologic and molecular subtype for colorectal adenomas concerning combined hormone therapy use (6) and cigarette smoking (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Is There Etiologic Heterogeneity between Subtypes of Childhood Acute Lymphoblastic Leukemia? A Review of Variation in Risk by Subtype

Williams

Yang

Hirsch

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Although substantial advances in the identification of cytogenomic subtypes of childhood acute lymphoblastic leukemia (ALL) have been made in recent decades, epidemiologic research characterizing the etiologic heterogeneity of ALL by subtype has not kept pace. The purpose of this review is to summarize the current literature concerning subtype-specific epidemiologic risk factor associations with ALL subtype defined by immunophenotype (e.g., B-cell vs. T-cell) and cytogenomics (including gross chromosomal events characterized by recurring numerical and structural abnormalities, along with cryptic balanced rearrangements, and focal gene deletions). In case-control analyses investigating nongenetic risk factors, home paint exposure is associated with hyperdi-ploid, MLL-rearranged, and ETV6-RUNX1 subtypes, yet there are few differences in risk factor associations between T-and B-ALL. Although the association between maternal smoking and ALL overall has been null, maternal smoking is associated with an increasing number of gene deletions among cases. GWAS-identified variants in ARID5B have been the most extensively studied and are strongly associated with hyperdiploid B-ALL. GATA3 single nucleotide variant rs3824662 shows a strong association with Ph-like ALL (OR ¼ 3.14). However, there have been relatively few population-based studies of adequate sample size to uncover risk factors that may define etiologic heterogeneity between and within the currently defined cytogenomic ALL subtypes.

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Reproductive risk factor associations with lobular and ductal carcinoma in the Carolina Breast Cancer Study

Cited by 13 publications

References 50 publications

Heterogeneity in risk factors for ductal and lobular breast carcinomas: A case–control study

Heterogeneity in risk factors for ductal and lobular breast carcinomas: A case–control study

Investigation Risk Factors for Breast Cancer in Women: A Case–Control Study in Arak, Iran

Is There Etiologic Heterogeneity between Subtypes of Childhood Acute Lymphoblastic Leukemia? A Review of Variation in Risk by Subtype

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