Reproductive suppression in subordinate female highveld mole-rats (Cryptomys hottentotus pretoriae): No role for endogenous opioid peptides

Toit, L. du; Bennett, Nigel C.; Gutjahr, Gundula H.; Coen, Clive W.

doi:10.1016/j.physbeh.2006.02.005

Cited by 8 publications

(3 citation statements)

References 32 publications

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“…A similar study done in female breeding and nonbreeding Damaraland mole-rats, failed to observe such an effect (Molteno and Bennett 2002). In two further species, which exhibit socially induced infertility of subordinates, highveld mole-rats (Cryptomys hottentotus pretoriae) and marmoset monkeys (Callithrix jacchus) comparable results were obtained (Abbott 1988;du Toit et al 2006). Moreover, recent evidence from sheep suggests that the blockade of KOR increases LH secretion in ovariectomized individuals treated with E2 at pre-pupertal age, but not at post-pubertal age.…”

Section: Influence Of Reproductive Status On Pdyn and Tac3 Gene Expre...mentioning

confidence: 74%

Reproductive status-dependent dynorphin and neurokinin B gene expression in female Damaraland mole-rats

Voigt

Bennett

2019

Journal of Chemical Neuroanatomy

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Section: Influence Of Reproductive Status On Pdyn and Tac3 Gene Expre...mentioning

confidence: 74%

Reproductive status-dependent dynorphin and neurokinin B gene expression in female Damaraland mole-rats

Voigt

Bennett

2019

Journal of Chemical Neuroanatomy

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“…Sexual dimorphism was observed in the organization of glutaminergic cells in the rat hypothalamic infindibular area for neurokinin B, but not for DYN (225). There was no role for endogenous opioid peptides in the reproductive suppression in subordinate female highveld mole-rats (1124).…”

Section: A Sexual Activity and Hormonesmentioning

confidence: 82%

Endogenous opiates and behavior: 2009

Bodnar

2010

Peptides

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“…Ahmed and Kurkar, 2014 [25] demonstrated that female rats received tramadol 40mg /kg body weight subcutaneously three times per week for 8 weeks showed reduction in the plasma levels of follicle-stimulating hormone and luteinizing hormone. Obvious reproductive failure was associated with administration of similar drugs such as opioid antagonist naloxone to the female rats [26] .…”

Section: Discussionmentioning

confidence: 99%

Histological and immunohistochemical study of the effects of tramadol administration on the ovaries of adult albino rats and the possible recovery after its Withdrawal.

Mohamed

2020

Egyptian Journal of Histology

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Background: Tramadol hydrochloride is a centrally active synthetic opioid. Tramadol is known to be highly effective in the treatment of the pain. Aim of the Work:The present work was conducted to outline the deleterious effects of tramadol administration on the ovaries of adult albino rats and the possible recovery after the tramadol withdrawal. Materials and Methods: Thirty adult virgin female albino rats were used in this study. They were classified into two groups; control group and experimental group. The experimental group is further divided into treated and withdrawal. Both the treated and the withdrawal groups were subcutaneously injected with Amadole in a dose of 40 mg/kg body weight three consecutive times weekly for 8 weeks while the withdrawal group was kept for another 8 weeks without treatment for the detection of the possible recovery. The rats were sacrificed. The ovaries were processed for histological and immunohistochemically study. Morphometric study was done in addition. Results: In the treated group, the ovaries had degenerated ovarian follicles with loss of their normal architecture and some atretic follicles could be detected. The secondary follicles showed primary oocytes surrounded by granulosa cells. The surrounding granulosa cells appeared swollen, disrupted, irregular with degenerated vacuolated cytoplasm. The cortical blood vessels were dilated and congested. The withdrawal group revealed degenerative changes that were comparable to the treated group. Conclusion:Tramadol induced deleterious effects on The structure of the ovary .These impairment were not improved with the withdrawal of tramadol.

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Reproductive suppression in subordinate female highveld mole-rats (Cryptomys hottentotus pretoriae): No role for endogenous opioid peptides

Cited by 8 publications

References 32 publications

Reproductive status-dependent dynorphin and neurokinin B gene expression in female Damaraland mole-rats

Reproductive status-dependent dynorphin and neurokinin B gene expression in female Damaraland mole-rats

Endogenous opiates and behavior: 2009

Histological and immunohistochemical study of the effects of tramadol administration on the ovaries of adult albino rats and the possible recovery after its Withdrawal.

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