Reproductive toxicity and disposition of 2,3,7,8‐tetrachlorodibenzo‐<i>p</i>‐dioxin in adult brook trout (<i>Salvelinus fontinalis</i>) following a dietary exposure

Tietge, Joseph E.; Johnson, Rodney D.; Jensen, Kathleen; Cook, Philip M.; Elonen, Gregory E.; Fernandez, Joseph D.; Holcombe, Gary W.; Lothenbach, Douglas; Nichols, John W.

doi:10.1002/etc.5620171206

Cited by 29 publications

(42 citation statements)

References 53 publications

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“…Effects of chronic, sublethal TCDD exposure on reproductive success of fish are a growing concern. While this has not been studied extensively, some studies suggest that sublethal exposure to TCDD impairs gonad development, ovulation and survival of offspring (recruitment) (Giesy et al, 2002; Jones et al, 2001; Tietge et al, 1998; Walker et al, 1994; Walter et al, 2000). …”

Section: Tcdd Toxicity In Adult and Juvenile Feral Fishmentioning

confidence: 99%

Reproductive and developmental toxicity of dioxin in fish

King‐Heiden

Mehta

Xiong

et al. 2012

Molecular and Cellular Endocrinology

146

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD or dioxin) is a global environmental contaminant and the prototypical ligand for investigating aryl hydrocarbon receptor (AHR)-mediated toxicity. Environmental exposure to TCDD results in developmental and reproductive toxicity in fish, birds and mammals. To resolve the ecotoxicological relevance and human health risks posed by exposure to dioxin-like AHR agonists, a vertebrate model is needed that allows for toxicity studies at various levels of biological organization, assesses adverse reproductive and developmental effects and establishes appropriate integrative correlations between different levels of effects. Here we describe the reproductive and developmental toxicity of TCDD in feral fish species and summarize how using the zebrafish model to investigate TCDD toxicity has enabled us to characterize the AHR signaling in fish and to better understand how dioxin-like chemicals induce toxicity. We propose that such studies can be used to predict the risks that AHR ligands pose to feral fish populations and provide a platform for integrating risk assessments for both ecologically relevant organisms and humans.

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Section: Tcdd Toxicity In Adult and Juvenile Feral Fishmentioning

confidence: 99%

Reproductive and developmental toxicity of dioxin in fish

King‐Heiden

Mehta

Xiong

et al. 2012

Molecular and Cellular Endocrinology

146

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“…Only a few studies are available on the dietary uptake of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in laboratory-exposed fish [12,13]. These experiments have typically used small * To whom correspondence may be addressed (jonespa7@msu.edu).…”

Section: Introductionmentioning

confidence: 99%

ACCUMULATION OF 2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN BY RAINBOW TROUT (ONCHORHYNCHUS MYKISS) AT ENVIRONMENTALLY RELEVANT DIETARY CONCENTRATIONS

Jones¹,

Kannan²,

Newsted³

et al. 2001

Environ Toxicol Chem

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Rainbow trout were fed a diet containing 1.8, 18, or 90 pg/g 3H-2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for up to 320 d. Concentrations of TCDD were determined in muscle, liver, and ovaries at 100, 150, 200, and 250 d. Concentrations of TCDD reached an apparent steady-state concentration in liver after 100 d of exposure, whereas concentrations in other tissues continued to increase until 150 d of exposure. The greatest portion of the total mass of TCDD was present in the muscle tissue with lesser proportions in other organs. As the ovaries developed before spawning, an increase occurred in the total mass of TCDD present in this tissue. The assimilation rate of TCDD during the initial 100 d of the exposure was determined to be between 10 and 30%. This is somewhat less than estimates derived based on both uptake and elimination constants determined during shorter exposures. Biomagnification factors (BMFs) were estimated for all tissues and exposure concentrations, and at all exposure periods. Lipid-normalized BMFs for muscle ranged from 0.38 to 1.51, which is consistent with the value of 1.0 predicted from fugacity theory. Uptake and depuration rate constants were determined and used to predict individual organ TCDD concentrations. Comparison with observed values indicated that the model could be used to predict tissue concentrations from the known concentrations of TCDD in food. This model will allow more refined risk assessments by predicting TCDD concentrations in sensitive tissues such as developing eggs.

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“…Healthy, disease‐free, 1 1/2‐year‐old brook trout were obtained on June 5, 1993, and were held at 12°C in 710‐L insulated holding tanks at the Duluth, Minnesota Environmental Protection Agency laboratory for 1 week. On June 10 and 11, fish were sorted by sex (determined by secondary sexual characteristics), measured, tagged, and randomly distributed into exposure chambers filled with flowing, sand‐filtered, degassed, oxygenated, ultraviolet sterilized freshwater from Lake Superior [33]. Fish were held and exposed in 24 100‐L insulated, double‐walled, stainless steel tanks housed in two fully contained and ventilated units (12 tanks per unit).…”

Section: Methodsmentioning

confidence: 99%

“…The experimental design, presented in detail by Tietge et al [33], is summarized graphically in Figure 1 and is discussed briefly here. Steady‐state whole‐body target concentrations of TCDD were achieved by feeding brook trout radiolabeled TCDD in food.…”

Section: Methodsmentioning

confidence: 99%

“…Six treatment groups in four replicate tanks were defined by the following whole‐body TCDD concentrations: 0.0, 75, 150, 300, 600, and 1,200 pg/g tissue. These whole‐body target concentrations, based on an egg:whole‐body ratio assumed to be 0.5, were chosen as bracketing the LC egg 50 concentrations of lake trout and brook trout [33]. Seventeen fish, in the sex ratio of 10 female, 6 male, and 1 unknown, were initially installed in each tank.…”

Section: Methodsmentioning

confidence: 99%

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Temporal trends in ethoxyresorufin‐o‐deethylase activity of brook trout (Salvelinus fontinalis) fed 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin

Cormier

Millward

Mueller³

et al. 2000

Enviro Toxic and Chemistry

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Changes in ethoxyresorufin-O-deethylase (EROD) activity were monitored through an extended 6-month dietary exposure to determine the relationship between EROD activity and uptake of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in brook trout, Salvelinus fontinalis. Brook trout were fed labeled TCDD during a 4-week loading phase and an 11-week maintenance phase to achieve whole-body concentrations of 0, 75, 150, 300, 600, and 1,200 pg TCDD/g fish. A spawning phase followed during which no TCDD was introduced. The TCDD had an extended half-life, with maximal levels detected in the late loading-early maintenance phases and 81 d after TCDD had been removed from the diet. Accumulation in liver increased as whole-body target concentration increased but was generally less than half of anticipated whole-body target concentrations. The EROD activity demonstrated a dose-dependent increase. Positive correlations were observed between EROD activity and TCDD body burdens for both males and females. For males, maximal induction was attained early in the maintenance phase and maintained during latter phases. For females, induction was characterized by a biphasic pattern. Maximal induction was attained during late loading-early maintenance, with an attenuated response observed just before spawning. In addition, the induction response was modulated by sex, as induction was lower in females when compared with males. If sexual biases are considered, increased EROD activity may serve as an indicator of level of TCDD exposure and a sublethal predictor of effects of exposure. Keywords-Ethoxyresorufin-O-deethylaseInduction 2,3,7,8-Tetrachlorodibenzo-p-dioxin Brook trout Salvelinus fontinalis EROD response of TCDD-fed brook trout

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Reproductive toxicity and disposition of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin in adult brook trout (Salvelinus fontinalis) following a dietary exposure

Cited by 29 publications

References 53 publications

Reproductive and developmental toxicity of dioxin in fish

Reproductive and developmental toxicity of dioxin in fish

ACCUMULATION OF 2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN BY RAINBOW TROUT (ONCHORHYNCHUS MYKISS) AT ENVIRONMENTALLY RELEVANT DIETARY CONCENTRATIONS

Temporal trends in ethoxyresorufin‐o‐deethylase activity of brook trout (Salvelinus fontinalis) fed 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin

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