Reproductive toxicity of acrylamide-treated male rats

Wang, Hao; Huang, Pan; Lie, Tietao; Li, Jian; Hutz, Reinhold J.; Li, Kui; Wei, Quanwei

doi:10.1016/j.reprotox.2009.11.002

Cited by 122 publications

(80 citation statements)

References 33 publications

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“…The authors concluded that this study provides evidence of endocrine disturbance to the testis, organ in which AA has been shown to cause tumours in experimental animals. Wang et al (2010b) treated male Sprague-Dawley rats of 21 days of age with 0, 5 and 10 mg/kg b.w. per day for 8 consecutive weeks.…”

Section: Mode Of Action Of Thyroid Toxicitymentioning

confidence: 99%

Scientific Opinion on acrylamide in food

Publication¹

2015

EFS2

341

170

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EFSA was asked to deliver a scientific opinion on acrylamide (AA) in food. AA has widespread uses as an industrial chemical. It is also formed when certain foods are prepared at temperatures above 120 °C and low moisture, especially in foods containing asparagine and reducing sugars. The CONTAM Panel evaluated 43 419 analytical results from food commodities. AA was found at the highest levels in solid coffee substitutes and coffee, and in potato fried products. Mean and 95th percentile dietary AA exposures across surveys and age groups were estimated at 0.4 to 1.9 µg/kg body weight (b.w.) per day and 0.6 to 3.4 µg/kg b.w. per day, respectively. The main contributor to total dietary exposure was generally the category 'Potato fried products (except potato crisps and snacks)'. Preferences in home-cooking can have a substantial impact on human dietary AA exposure. Upon oral intake, AA is absorbed from the gastrointestinal tract and distributed to all organs. AA is extensively metabolised, mostly by conjugation with glutathione but also by epoxidation to glycidamide (GA). Formation of GA is considered to represent the route underlying the genotoxicity and carcinogenicity of AA. Neurotoxicity, adverse effects on male reproduction, developmental toxicity and carcinogenicity were identified as possible critical endpoints for AA toxicity from experimental animal studies. The data from human studies were inadequate for dose-response assessment. The CONTAM Panel selected BMDL 10 values of 0.43 mg/kg b.w. per day for peripheral neuropathy in rats and of 0.17 mg/kg b.w. per day for neoplastic effects in mice. The Panel concluded that the current levels of dietary exposure to AA are not of concern with respect to non-neoplastic effects. However, although the epidemiological associations have not demonstrated AA to be a human carcinogen, the margins of exposure (MOEs) indicate a concern for neoplastic effects based on animal evidence. © European Food SUMMARYFollowing a request from the European Commission, the Panel on Contaminants in the Food Chain (CONTAM Panel) was asked to deliver a scientific opinion on acrylamide (AA) in food. The Panel developed the draft scientific opinion which underwent a public consultation from 1 July 2014 to 15 September 2014. The comments received and how they were taken into account when finalising the scientific opinion were published in an EFSA Technical Report (EFSA, 2015).AA is a low molecular weight, highly water soluble, organic compound. It is used inter alia as an industrial chemical and in the production of polyacrylamides. Heightened concerns about exposure to AA arose in 2002 when it was discovered that it forms when certain foods are prepared at temperatures usually above 120 °C and low moisture. It forms, at least in part, due to a Maillard reaction between certain amino acids, such as asparagine, and reducing sugars. However, several other pathways and precursors have also been proposed to contribute to AA formation. AA forms in numerous baked or fried carbohydrate-rich f...

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Section: Mode Of Action Of Thyroid Toxicitymentioning

confidence: 99%

Scientific Opinion on acrylamide in food

Publication¹

2015

EFS2

341

170

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“…Toxicity for males may result from adverse effects on sexual maturation, gamete production and transport, sexual behavior and fertility (Kimmel et al 1995). A variety of chemical and physical agents, including the natural occurring substances found in plants, have been associated with male reproductive toxicity (Dixit et al 1989, Montanari et al 1998, He et al 2010, Wang et al 2010). Folk medicine is traditionally employed by many people throughout the world.…”

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confidence: 99%

Assessment of sperm production and reproductive organs of Wistar rats to long-term exposure of Caesalpinia ferrea

Lucinda

Rocha

Reboredo

et al. 2010

An. Acad. Bras. Ciênc.

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Caesalpinia ferrea Mart (Leguminosae) is a medicinal plant used to treat diabetes, among other therapeutic properties, but which is also reported to have hepatotoxic effects. Although it contains substances such as flavonoids and coumarin, which are known to have antifertility activity, no studies have apparently been conducted to evaluate the potential adverse side effects of this plant on the function of the reproductive system after a chronic treatment. Therefore, this investigation was carried out to evaluate the effect and safety of the long-term exposure to C. ferrea on male Wistar rats' vital organs, reproductive system and sperm production. Adult and immature male rats were treated with an aqueous extract of C. ferrea at a dose level of 300 mg/kg of body weight, administered during one or two spermatogenic cycles of this species. The reproductive and vital organs were analyzed, and sperm was collected from the epididymal secretion of the right epididymis cauda. The long-term administration of C. ferrea did not significantly alter the body, vital and reproductive organs weights. Gamete production was not affected either. The chronic assessment of C. ferrea suggests that this plant does not affect the normal functioning of the Wistar rat reproductive system.

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“…Acrylamide decreased growth of rats and epididymal sperm reserves (36) Female mice Reproductive toxicity in acrylamide-treated female mice.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, administration of 0.5-10 mg/kg of AA retarded growth of rats and decrease epididymal sperm reserves compared with control group. In addition, histopathologic lesions were also present in the testis of treated rats (36). In one study, after ip injection of AA doses (20 mg/kg) to male rats, testosterone and prolactin concentrations were decreased as a dose-dependence manner (37).…”

Section: Reproductive Toxicity Of Acrylamidementioning

confidence: 98%