Reproductive toxicity of low-level lead exposure in men

Telišman, Spomenka; Čolak, Božo; Pizent, Alica; Jurasović, Jasna; Cvitković, Petar

doi:10.1016/j.envres.2007.05.011

Cited by 202 publications

(160 citation statements)

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“…Recently, Telisman et al [73] reported reproductive toxicity of low-level lead exposure in men with no occupational exposure to metals. In this study semen quality, seminal plasma indicators of secretory function of the prostate and seminal vesicles, sex hormones in serum, and biomarkers of lead, cadmium, copper, zinc, and selenium body burden were measured in 240 Croatian men 19-52 years of age.…”

Section: Metalsmentioning

confidence: 99%

Occupational and Lifestyle Exposures on Male Infertility: A Mini Review

Ten¹,

Mendiola²,

Torres-Cantero³

et al. 2008

TORSJ

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Human semen quality may be declining due to environmental pollutants, occupational exposures or changes in lifestyle. Nonetheless, we still know little about the impact of those factors on male fertility. Some heavy metals, volatile organic compounds or xenoestrogens may compromise reproductive male function. This process could take place along the human life cycle and not only in certain stages of development. We review the main factors that affect human male fertility and their possible influence in current human reproduction.

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Section: Metalsmentioning

confidence: 99%

Occupational and Lifestyle Exposures on Male Infertility: A Mini Review

Ten¹,

Mendiola²,

Torres-Cantero³

et al. 2008

TORSJ

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mentioning

confidence: 99%

“…In spite of a decreasing trend of Pb exposure in Croatia (7)(8)(9)(10)(11) and worldwide, Pb toxicity remains a signifi cant public health problem. Recent evidence has indicated that even low-to-moderate blood lead (BPb) levels can signifi cantly reduce human semen quality (8,10,12). Pb compounds have been classifi ed by the International Agency for Research on Cancer (IARC) as possible human carcinogens (Group 2B) on the basis of suffi cient evidence of carcinogenicity in experimental animals, but inadequate evidence of carcinogenicity in humans (13)(14)(15).…”

mentioning

confidence: 99%

Prostate-Specific Antigen (PSA) in Serum in Relation to Blood Lead Concentration and Alcohol Consumption in Men

Pizent

Čolak²,

Kljaković

et al. 2009

Archives of Industrial Hygiene and Toxicology

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The combined infl uence of age, smoking, alcohol, blood lead and cadmium concentrations, and serum copper, zinc, and selenium concentrations on prostate-specifi c antigen (PSA) in serum was investigated in a group of 57 men aged 21 years to 40 years. The subjects had no occupational exposure to metals and no other known reasons suspected of infl uencing prostate function or metal metabolism. No signifi cant correlation was found between PSA and any of the explanatory variables considered. Nevertheless, when taking into account all of the above-mentioned potentially explanatory variables, the results of stepwise multiple regression showed a signifi cant increase in PSA with respect to an increase in blood lead, and a decrease in PSA with respect to an increase in intensity of alcohol consumption. The median and range values of blood lead concentration in the 57 men were 26.0 µg L -1 and (10.1 to 108.0) µg L -1 , respectively. These results suggest that even a low-level environmental lead exposure, common for general populations worldwide, may contribute to the risk of prostate cancer in men. The infl uence of lead as well as cadmium, zinc, and selenium on prostate damage and PSA should be further investigated in relatively young men for the purpose of disease prevention.

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“…However, other animal studies, mainly about histopathological, spermatozoal, and hormonal end points, indicated that certain species and strains were quite resistant to the reproductive toxicity of lead (Goyer, 1993). The human studies focused mainly on semen quality, endocrine function, and birth rates in occupationally exposed subjects, and showed that exposure to concentrations of inorganic lead > 40 µg/dL in blood impaired male reproductive function by reducing sperm count, volume, and density, or changing sperm motility and morfology (Pant et al, 2014;Telišman et al, 2007).…”

Section: Reproductive and Developmental Toxicitymentioning

confidence: 99%

Lead Exposure and Environmental Health

Patočka¹,

Kuča²

2016

MMSL

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SummaryLead (Pb), which is widely used in industry, is a common element found in low concentrations in the Earth's crust. Lead has been used since prehistoric times. As a highly toxic heavy metal, the pollution and exposure risks of lead are of widespread concern for human health. This environmental contaminant causing irreversible health effects mainly in children. Especially children under the age of six are most at risk for lead poisoning. Lead toxicity causes hematological, gastrointestinal, and neurological dysfunction. Symptoms are usually noted with blood lead greater than 2 μmol/litre. Severe or prolonged exposure may also cause chronic nephropathy, hypertension, and reproductive impairment. Lead inhibits some enzymes, alters cellular calcium metabolism, stimulates synthesis of binding proteins in kidney, brain, and bone, and slows down nerve conduction. The emission sources and pathological effects of lead are discussed.

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Reproductive toxicity of low-level lead exposure in men

Cited by 202 publications

References 53 publications

Occupational and Lifestyle Exposures on Male Infertility: A Mini Review

Occupational and Lifestyle Exposures on Male Infertility: A Mini Review

Prostate-Specific Antigen (PSA) in Serum in Relation to Blood Lead Concentration and Alcohol Consumption in Men

Lead Exposure and Environmental Health

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