Reproductive toxicity of methomyl insecticide in male rats and protective effect of folic acid

Shalaby, Mohamed A.; Zorba, H.Y. El; Ziada, Reem M.

doi:10.1016/j.fct.2010.08.027

Cited by 53 publications

(48 citation statements)

References 11 publications

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“…DNA methylation was demonstrated as the mechanism behind the protection for BPA (Dolinoy et al, 2007), and was proposed for methomyl insecticide (Shalaby et al, 2010) and arsenic (Howe et al, 2014; Lambrou et al, 2012; Tsang et al, 2012). Exposure to higher ambient levels of traffic particles can decrease DNA methylation (Baccarelli et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder

et al. 2017

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We examined interactions between periconceptional folic acid (FA) and air pollution exposure on risk of ASD. Mothers exposed to higher levels of air pollution during the first trimester of pregnancy and who reported low supplemental FA intake during the first pregnancy month were at a higher ASD risk compared to mothers exposed to lower levels of air pollution and who reported high first month FA intake. Our results suggest that periconceptional FA intake may reduce ASD risk in those with high prenatal air pollution exposure.

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Section: Discussionmentioning

confidence: 99%

Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder

et al. 2017

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“…Similarly, Al-Thani et al (2003) observed impaired spermatogenesis coupled with the reduction in the number of females fertilized by male mice treated with the pesticide amitraz. A decline in fertility was also observed by Joshi et al (2007), Yu et al (2009) and Shalaby et al (2010) after the administration of chlorpyrifos, carbendazim or methomyl pesticides to male rats. Maneb-induced infertility was associated to serum testosterone inhibition.…”

Section: Discussionmentioning

confidence: 93%

Protective effect ofBasella albaandCarpolobia albaextracts against maneb-induced male infertility

Manfo¹,

Nantia²,

Déchaud³

et al. 2013

Pharmaceutical Biology

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Context: Male infertility is one of the leading causes of social frustration and marginalization, mainly in the developing world. It is attributed to many factors including exposure to agropesticides such as manganese ethylenebis (dithiocarbamate) (maneb), which is one of the most frequently used fungicides in Cameroon. Previous reports support efficiency of some medicinal plants commonly used in Cameroonian folk medicine for the treatment of this disorder. Objective: The present study was aimed at assessing the protective effect of extracts from selected plant species, namely Basella alba L. (Basellaceae) (MEBa) and Carpolobia alba G. Don (Polygalaceae) (AECa), in alleviating the maneb-induced impairment of male reproductive function in Wistar albino rats. Materials and methods: The rats were treated with vehicle, plant extract (MEBa or AECa), maneb and maneb plus plant extract, respectively, and their fertility was assessed. Animals were thereafter sacrificed and organs (liver, kidneys and reproductive organs) were dissected out and weighed. Serum androgens together with alanine aminotransferase, liver glutathione and thiobarbituric acid reactive species (TBARS) were also measured. Results and discussion: From this study, both plant extracts stimulated testosterone and improved fertility. Administration of MEBa plus maneb prevented fertility reduction by maneb and minimized the inhibitory effect of maneb on testosterone levels. AECa also improved fertility of the maneb-exposed rats, though without restoring testosterone levels, and other investigated parameters remained unaffected by different treatments. Conclusion: These findings emphasized the beneficial effects of B. alba and C. alba extracts on male fertility, and suggest their protective effect against maneb-induced toxicity in male reproductive function.

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“…It induced testicular lesions characterized by moderate to severe degenerative changes of seminiferous tubules and incomplete arrest of spermatogenesis. These toxic effects are not persistent (Shalaby et al, 2010). Propoxur (2-isopropoxy-phenyl-N-methylcarbamate), a carbamate pesticide, administered to adult male Wistar rats for 90 successive days led to a concentration-dependent increase in relative weights of testis and epididymis and a decrease in sperm density, serum and intratesticular total cholesterol concentrations, and intratesticular total proteins in treated rats.…”

Section: Effects Of Carbamate Insecticides On Male Reproductive Systemmentioning

confidence: 99%

“…Methomyl, a Carbamate insecticide administered to male rat daily for 65 successive days at two doses (0.5 and 1 mg/kg body weight) significantly decreased serum testosterone level (Shalaby et al, 2010). Subchronic exposure to methomyl (Carbamate) induce a significant decrease in the level of testosterone in the intoxicated rats, while the levels of FSH, LH and prolactin significantly increased (Mahgoub and EI-Medany, 2006).…”

Section: Effects Of Carbamate Insecticides On Endocrine Systemmentioning

confidence: 99%

Reproductive and Developmental Toxicity of Insecticides

Ngoula¹,

Ngouateu²,

Raphaël³

et al. 2012

Insecticides - Advances in Integrated Pest Management

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Reproductive toxicity of methomyl insecticide in male rats and protective effect of folic acid

Cited by 53 publications

References 11 publications

Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder

Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder

Protective effect ofBasella albaandCarpolobia albaextracts against maneb-induced male infertility

Reproductive and Developmental Toxicity of Insecticides

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