Reproductive toxicity of microplastics in female mice and their offspring from induction of oxidative stress

Zhang, Yingbin; Wang, Xiyue; Zhao, Yifan; Zhao, Jianglin; Yu, Tong; Yao, Yupei; Zhao, Rui; Yu, Ruiluan; Li, Jun; Su, Jianmin

doi:10.1016/j.envpol.2023.121482

Cited by 42 publications

(11 citation statements)

References 47 publications

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“…These data suggest that eEF1a1 may be a target regulator for ROS. Numerous studies have suggested the role of increased oxidative stress in spindle defects and chromosomal abnormalities in oocytes, ultimately compromising developmental competence 55‐57 . In our study, the expression of eEF1a1 was increased in RAGE 344‐355 ‐treated oocytes, and subsequent experiments revealed that overexpressing eEF1a1 partially mitigated the spindle defects and chromosome misalignment in DHEA‐treated oocytes.…”

Section: Discussionsupporting

confidence: 53%

Peptide derived from RAGE efficiently improves oocyte development through attenuating oxidative stress in oocytes of mice with polycystic ovary syndrome

Hou,

Ling,

Guo

et al. 2024

The FASEB Journal

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Polycystic ovary syndrome (PCOS) is a common and complex endocrine disorder in reproductive‐aged women that frequently leads to infertility due to poor oocyte quality. In this study, we identified a new active peptide (advanced glycation end products receptors RAGE344‐355) from PCOS follicular fluid using mass spectrometry. We found that supplementing PCOS‐like mouse oocytes with RAGE344‐355 attenuated both meiotic defects and oxidative stress levels, ultimately preventing developmental defects. Additionally, our results suggest that RAGE344‐355 may interact with eEF1a1 to mitigate oxidative meiotic defects in PCOS‐like mouse oocytes. These findings highlight the potential for further clinical development of RAGE344‐355 as a potent supplement and therapeutic option for women with PCOS. This research addresses an important clinical problem and offers promising opportunities for improving oocyte quality in PCOS patients.

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Section: Discussionsupporting

confidence: 53%

Peptide derived from RAGE efficiently improves oocyte development through attenuating oxidative stress in oocytes of mice with polycystic ovary syndrome

Hou,

Ling,

Guo

et al. 2024

The FASEB Journal

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“…Oral administration of MPs in gravid mice resulted in a faster rate of embryonic resorption and placental and fetal development (Yang, 2023). Moreover, MPs may alter oocyte maturation and function, resulting in decreased fertility (Zhang et al, 2023). In this work, the authors demonstrated that the administration of PS-MPs impaired oocyte maturation and decreased the quality of oocytes by promoting apoptosis via increased ROS levels.…”

Section: Discussionmentioning

confidence: 99%

“…Although there is a lack of studies on the effects of MPs on humans, there is evidence from animal models demonstrating their adverse effects. In a study on mice, after administration of polyethylene MPs (PE-MPs) of 10-150 μm, (40 mg/kg/day) for 30 days, reduced oocyte maturation was observed, with a decreased capacity for fertilization of these oocytes, alterations in the development of the resulting embryos, related to oxidative stress damage with implications for DNA and mitochondrial dysfunction in the exposed oocytes (Zhang et al, 2023). Another study has shown a reduction in plasma levels of 17β-estradiol (E2) and testosterone (T) in female Oryzias melastigma after 60 days of exposure to PS-MPs (Wang et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

First evidence of microplastics in human ovarian follicular fluid: an emerging threat to female fertility

Montano,

Raimondo,

Piscopo

et al. 2024

Preprint

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Plastic pollution is a pressing global issue, with over 400 million tons produced annually and projections of 1.1 billion tons by 2050. Microplastics (MPs), ranging from 5 mm to 1 micron, are pervasive in the environment. They are found in air, sea, freshwater, soils, food chains and studies show that tiny MPs, smaller than 10 μm, can cross cellular membranes, posing potential health risks through oxidative stress, inflammation, immune dysfunction, neurotoxicity and reprotoxicity. In recent years, research has shown that microplastics have negative effects on the female reproductive systems of animals. However, there is still a lack of evidence on how the accumulation of microplastics affects the reproductive health of human females. This study aimed to examine the presence of microplastics in the ovarian follicular fluid of 18 women undergoing assisted reproductive treatment whose samples were processed using a patented method endorsed nationally and internationally. Plastic particles <10 micron were measured using SEM with EDX detection. Preventive measures were taken to avoid contamination during the process. Microplastics (dimensions <10 micron) were detected in 14 out of 18 samples of follicular fluid, with an average of 2191 p/ml (0 - 7181p/ml) and with a mean diameter of MPs of 4.48 micron (3.18-5.54 micron). A significant correlation was found between microplastic concentration and FSH (p-value <0.05), as well as a weak correlation with BMI, age and Estradiol. There was no correlation with fertilization outcomes, miscarriages, or live birth. This is the first study to provide evidence for microplastics' presence in ovarian follicular fluid in women undergoing assisted reproductive treatment, representing a potential threat to female reproductive function.

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“…Mitochondrial damage attracted by MPs exposure has been frequently reported ( Zhang et al, 2022a ; Gu et al, 2023 ). MPs significantly increased oxidation levels in oocytes and embryos, and produced mitochondrial dysfunction and apoptosis ( Zhang et al, 2023 ). Based on our experiment, MPs treatment gave rise mitochondrial structural damage, and accompanied by the disturbance of dynamics ( Figure 2 ), which was consistent with other MPs studies ( Elsheikh et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

New insights into the spleen injury by mitochondrial dysfunction of chicken under polystyrene microplastics stress

Guo,

Geng,

Zhang

et al. 2024

Poultry Science

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Reproductive toxicity of microplastics in female mice and their offspring from induction of oxidative stress

Cited by 42 publications

References 47 publications

Peptide derived from RAGE efficiently improves oocyte development through attenuating oxidative stress in oocytes of mice with polycystic ovary syndrome

Peptide derived from RAGE efficiently improves oocyte development through attenuating oxidative stress in oocytes of mice with polycystic ovary syndrome

First evidence of microplastics in human ovarian follicular fluid: an emerging threat to female fertility

New insights into the spleen injury by mitochondrial dysfunction of chicken under polystyrene microplastics stress

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