Reproductive Toxicity of Tobacco Shisha Smoking on Semen Parameters and Hormones Levels among Adult Egyptian Men

Fawzy, Irene Atef; Kamal, Nashwa Nabil; Abdulla, Ahlam M.

doi:10.3923/rjet.2011.282.292

Cited by 16 publications

(10 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fawzy et al . () showed that Shisha (water pipe) and cigarette smoking impose toxic effects on sperm parameters and hormone levels; they found that smoking caused a decrease in sperm count, motility and percentage in spermatozoa with normal morphology. Recently, Davar et al .…”

Section: Discussionmentioning

confidence: 99%

Impact of cigarette smoking on histone (H2B) to protamine ratio in human spermatozoa and its relation to sperm parameters

et al. 2014

View full text Add to dashboard Cite

SUMMARYSmoking is strongly associated with abnormalities in histone-to-protamine transition and with alteration of protamine expression in human spermatozoa. A proper protamine to histone ratio is, however, essential for sperm chromatin maturity and DNA integrity. Alterations in these sperm nuclear proteins were observed in infertile men. The present prospective study is aimed at evaluating the possible relationship among smoking, semen quality and the histone-to-protamine transition ratio in mature spermatozoa. Histone H2B and protamine 1 (P1) and 2 (P2) were quantified using acid-urea polyacrylamide gel electrophoresis in the spermatozoa of 35 smokers and 19 non-smokers. Levels of lipid peroxidation marker malondialdehyde (MDA) were measured in seminal plasma by thiobarbituric acid assay. Cotinine concentrations were determined in seminal plasma using an enzyme-linked immunosorbent assay. Histone H2B levels in smokers (292.27 AE 58.24 ng/10 6 ) were significantly higher (p = 0.001) than that of non-smokers (109.1 AE 43.70 ng/10 6 ), besides, a significant difference (p > 0.0001) was found for the P1 and P2 ratio between smokers (1.71 AE 0.071) and non-smokers (1.05 AE 0.033). The H2B/(H2B+P1 + P2) ratio (0.29 AE 0.71) of smokers were significantly higher (p = <0.0001) than that of non-smokers (0.12 AE 0.01). The concentrations of MDA (lM) (7.13 AE 1.15) and cotinine (ng/mL) (60.44 AE 31.32) in seminal plasma of smokers were significantly higher (p = 0.001) than those in the samples of the non-smoker group (4.42 AE 1.16 and 2.01 AE 2.84 respectively). In addition, smokers showed significantly (p ≤ 0.002) lower sperm count, motility (p = 0.018), vitality (p = 0.009) and membrane integrity (p = 0.0001) than non-smokers. These results reveal that patients who smoke possess a higher proportion of spermatozoa with an alteration of the histone to protamine ratio than patients who do not smoke, and suggest that cigarette smoking may inversely affect male fertility.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of cigarette smoking on histone (H2B) to protamine ratio in human spermatozoa and its relation to sperm parameters

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The serum concentration of cadmium had a linear correlation with TNF-α and IFN-γ, but not with IL-4 [ 83 ], with consequent poor sperm parameters [ 84 ]. Fawzy et al [ 85 ] reported that both sheesha and cigarette smoking adversely affected semen quality. Sheesha smoking was more significantly associated with a decrease in sperm with a normal morphology and lower testosterone levels relative to cigarette smoking [ 85 ].…”

Section: Smoking and Sperm Parametersmentioning

confidence: 99%

“…Fawzy et al [ 85 ] reported that both sheesha and cigarette smoking adversely affected semen quality. Sheesha smoking was more significantly associated with a decrease in sperm with a normal morphology and lower testosterone levels relative to cigarette smoking [ 85 ]. In two studies where the men were followed for up to 12 months after smoking cessation, both studies reported a marked improvement in semen quality [ 86 , 87 ].…”

Section: Smoking and Sperm Parametersmentioning

confidence: 99%

Sperm Parameters: Paradigmatic Index of Good Health and Longevity

Omu¹

2013

Med Princ Pract

View full text Add to dashboard Cite

Since the discovery of spermatozoon by Anton van Leeuwenhoek in 1677, there has been an ever increasing understanding of its role in reproduction. Many factors adversely affect sperm quality, including varicocele, accessory gland infection, immunological factors, congenital abnormalities, and iatrogenic systemic and endocrine causes, such as diabetes mellitus, obesity, metabolic syndrome, and smoking. The mechanisms responsible for the association between poor sperm parameters and ill health may include oxidative stress, low-grade inflammation, low testosterone, and low sex-hormone-binding globulin. Oxidative stress in the testicular microenvironment may result in decreased spermatogenesis and sperm DNA damage, loss of sperm motility, and abnormal sperm morphology. Low testosterone caused by advanced age, visceral obesity, and inflammation is associated with the development of cardiovascular disease. Hence, semen analysis has an important role in the routine evaluation of idiopathic male infertility, usually manifested as low sperm counts, impaired sperm motility, or absence of sperm, and remains the most common single diagnostic tool. Several studies have shown an inverse relationship between semen quality and medical disorders. This review elucidates the effect of medical disorders and social habits on sperm quality, the mechanisms that are involved in the impairment of sperm quality, and whether or not sperm quality can be used as an index of good health and longevity in a man.

show abstract

“…Previous studies have shown that nicotine exposure during intra‐uterine and lactation phases increase the blood levels of FSH and LH as well as alter the structure of Sertoli cells in rats (Paccola & Miraglia, ). Higher levels of testosterone, FSH and LH were observed in waterpipe smokers compared with nonsmokers (Fawzy et al, ). The increased FSH level is involved in abnormal spermatogenesis (Gordetsky, van Wijngaarden, & O'Brien, ).…”

Section: Discussionmentioning

confidence: 99%

“…The exposure to WTS caused damage to the reproductive system in males. It reduced sperm count, disturbed sperms' morphology and altered the hormonal level in young men (Fawzy, Kamal, & Abdulla, ). Prenatal exposure to WTS negatively affected the offspring.…”

Section: Introductionmentioning

confidence: 99%

Influence of prenatal waterpipe tobacco smoke exposure on reproductive hormones and oxidative stress of adult male offspring rats

et al. 2019

View full text Add to dashboard Cite

Male infertility is adversely affected by tobacco cigarette smoking. Herein, the effects of prenatal waterpipe tobacco smoke (WTS) exposure on reproductive hormones and oxidative stress of adult offspring rats were evaluated. Pregnant rats received either fresh air or mainstream WTS (2 hr daily). Pregnancy outcomes, circulatory levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) and prolactin, testicular levels of oestrogen, testosterone and oxidative stress biomarkers [catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx) and thiobarbituric acid reactive substances (TBARS)] were assessed in their adult male offspring rats. Prenatal WTS exposure reduced the number of born offspring, female to pups ratio and birthweight (p < 0.05). Prenatal WTS exposure increased the circulatory levels of FSH and the testicular levels of oestrogen, testosterone and TBARS and catalase activity compared with control group (p < 0.05). However, GPx activity was reduced by WTS exposure (p < 0.05). There appeared to be a trend of increased LH and prolactin levels with prenatal WTS exposure; however, it was not statistically significant compared with control group (p > 0.05). The activity of SOD was not affected by prenatal WTS exposure (p > 0.05). In conclusion, prenatal WTS exposure altered reproductive hormones as well as oxidative stress biomarkers in adult male offspring rats.

show abstract

Reproductive Toxicity of Tobacco Shisha Smoking on Semen Parameters and Hormones Levels among Adult Egyptian Men

Cited by 16 publications

References 14 publications

Impact of cigarette smoking on histone (H2B) to protamine ratio in human spermatozoa and its relation to sperm parameters

Impact of cigarette smoking on histone (H2B) to protamine ratio in human spermatozoa and its relation to sperm parameters

Sperm Parameters: Paradigmatic Index of Good Health and Longevity

Influence of prenatal waterpipe tobacco smoke exposure on reproductive hormones and oxidative stress of adult male offspring rats

Contact Info

Product

Resources

About