The temperament (Mizaj) of the body is an essential constituent for health conservancy and diagnosis of several diseases. Hence, general body temperament and uterine dystemperament (Su’-i-Mizaj) with abnormal vaginal discharge (Salayan al-Rahim) need evaluation. In addition, we also applied a computational intelligence technique for enhancing scientific validity to classify the warm-cold and wet-dry temperaments. This trial included a total of 66 participants with a vaginal discharge of reproductive age. Data included demographic characteristics of the participants, symptoms associated with vaginal discharge, women’s general temperament, and symptoms of uterine dystemperament. Correlation between general body temperament and age, abnormal vaginal discharge, and its associated symptoms was also performed. Additionally, we used the Support Vector Machine-Radial Basis Function (SVM-RBF) model to classify the warm-cold and wet-dry temperaments. Warm general temperament was highly prevalent (77.27%), followed by moderate (19.69%) on the warm-cold temperament scale. In wet-dry temperament, moderate general body temperament (50%) was more prevalent. In warm-cold and wet-dry scores, 78.78% and 74.24% had warm and wet uterine dystemperament, respectively. The age and symptoms were correlated with general temperament. A strong positive correlation was found between warm general temperament and warm dystemperament of the uterus (r = 0.40, p < 0.009). In addition, our SVM-RBF CV-5 classification model achieved the highest accuracy (99.2%). Our results showed that vaginal discharge is more common in warm general temperament and warm-wet dystemperament of the uterus. The same has been proven by computational intelligence. Nevertheless, vaginal discharge can also happen in normal and other temperaments.