2016
DOI: 10.1016/j.coph.2015.09.007
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Reprogramming of macrophages — new opportunities for therapeutic targeting

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Cited by 66 publications
(49 citation statements)
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“…36 Our results provide a cautionary note to this approach, indicating that constitutive apoptosis in the tumor or apoptosis induced by repolarized, cytotoxic TAMs or by combination radiation or chemotherapy could militate against therapeutic success by contributing to what has been aptly termed ‘a misdirected tissue repair response'. 2 Further studies are required to identify the mechanisms responsible for the reprogramming of cytotoxic TAMs by apoptotic tumor cells as these could provide critical therapeutic targets.…”
Section: Discussionmentioning
confidence: 90%
“…36 Our results provide a cautionary note to this approach, indicating that constitutive apoptosis in the tumor or apoptosis induced by repolarized, cytotoxic TAMs or by combination radiation or chemotherapy could militate against therapeutic success by contributing to what has been aptly termed ‘a misdirected tissue repair response'. 2 Further studies are required to identify the mechanisms responsible for the reprogramming of cytotoxic TAMs by apoptotic tumor cells as these could provide critical therapeutic targets.…”
Section: Discussionmentioning
confidence: 90%
“…The concept that macrophages in the wounds of Mac‐1 −/− mice exist primarily in non‐traditional phenotypes can be explained by emerging studies on the complexity of this cell type. Recent studies have demonstrated that macrophage phenotypes might be best considered in a multi‐dimensional model . In particular, the analysis of genome‐wide transcriptional profiling of macrophages now suggests a very complex macrophage response to stress signals .…”
Section: Discussionmentioning
confidence: 99%
“…Because knockdown of whole genes may lead to unanticipated off-target effects, identifying disease-relevant isoform-level differences in a tissue- or cell-specific manner may open the door for more selective therapeutic targeting in re-programming macrophage phenotype, a focus of increasing interest in clinical translation. 8,67,68 Here we demonstrated that M1-HMDM activation was indeed associated with many changes on the isoform level, including more than 200 differential AS events. Although the number of AS events was far fewer than the number of differentially expressed genes in M1 activation, these AS events were enriched for a network of biologically relevant genes involved in macrophage functions such as autophagy (e.g., PLD1 ) 69 as well as immune processes (e.g., CD74 and TLR4 ), 70-73 all of which are linked to the modulation of macrophage inflammation.…”
Section: Discussionmentioning
confidence: 63%