Reprogramming of rhythmic liver metabolism by intestinal clock

Chen, Min; Dang, Yongkang; Xiao, Yifei; Zhang, Fugui; Sun, Guang; Jiang, Xuejun; Zhang, Li; Du, Jianhao; Duan, Shuyi; Zhang, Xiaojian; Qin, Z. H.; Yang, Jing; Liu, Kaisheng; Wu, Baojian

doi:10.1016/j.jhep.2023.04.040

Cited by 9 publications

(2 citation statements)

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“…In addition to the role of immune cells in diabetes, intestinal epithelial cell‐specific Bmal1 knockout can remodel diurnal hepatic metabolism by shifting to gluconeogenesis from lipogenesis during the dark phase, and elevate the production of glucose and insulin insensitivity, leading to an enhanced susceptibility of diabetes in mice. 10 Adipocyte‐specific deletion of Bmal1 results in obesity accompanied with reduced energy expenditure, attenuated food intake rhythm, and increased food intake via decreasing circulating polyunsaturated fatty acid concentration and affecting the levels of neurotransmitters responsible for appetite regulation in hypothalamic feeding centers. 189 Recent advancements in chronobiology have shed light on a significant role of the hepatocyte clock in the regulation of metabolic disorders associated with inflammation.…”

Section: Circadian Regulation Of Diseasesmentioning

confidence: 99%

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The role of circadian clock in regulating cell functions: implications for diseases

Lin,

He,

Cai

et al. 2024

MedComm

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The circadian clock system orchestrates daily behavioral and physiological rhythms, facilitating adaptation to environmental and internal oscillations. Disruptions in circadian rhythms have been linked to increased susceptibility to various diseases and can exacerbate existing conditions. This review delves into the intricate regulation of diurnal gene expression and cell function by circadian clocks across diverse tissues. . Specifically, we explore the rhythmicity of gene expressions, behaviors, and functions in both immune and non‐immune cells, elucidating the regulatory effects and mechanisms imposed by circadian clocks. A detailed discussion is centered on elucidating the complex functions of circadian clocks in regulating key cellular signaling pathways. We further review the circadian regulation in diverse diseases, with a focus on inflammatory diseases, cancers, and systemic diseases. By highlighting the intimate interplay between circadian clocks and diseases, especially through clock‐controlled cell function, this review contributes to the development of novel disease intervention strategies. This enhanced understanding holds significant promise for the design of targeted therapies that can exploit the circadian regulation mechanisms for improved treatment efficacy.

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Section: Circadian Regulation Of Diseasesmentioning

confidence: 99%

“… 5 , 6 , 7 , 8 , 9 For example, the intestinal clock orchestrates the hepatic rhythmic transcriptome and diurnal metabolism, thereby underpinning hepatic metabolic homeostasis. 10 Various factors, such as brain injuries, diseases, sleep deprivation, and trans‐meridian travel result in disrupted circadian rhythm. 11 , 12 …”

Section: Introductionmentioning

confidence: 99%