Reprogramming stem cells in regenerative medicine

Mao, Jiayi; Saiding, Qimanguli; Qian, Shutong; Liu, Zhimo; Zhao, Binfan; Zhao, Qing; Lu, Bolun; Mao, Xiyuan; Zhang, Liucheng; Zhang, Yuguang; Sun, Xiaoming; Cui, Wenguo

doi:10.1002/smmd.20220005

Cited by 27 publications

(16 citation statements)

References 78 publications

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“…The stats module of the Python software was utilized to perform the t-test on sponge-relevant GPR, and p < 0.05 was considered statistically significant. [35][36][37] 3. Results and discussion…”

Section: Discussionmentioning

confidence: 99%

Investigation of sponge medium for efficient concurrent tumor treating fields and radiotherapy for glioblastomas

Zheng,

Zhu,

Guo

et al. 2023

Nanoscale

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Section: Discussionmentioning

confidence: 99%

Investigation of sponge medium for efficient concurrent tumor treating fields and radiotherapy for glioblastomas

Zheng,

Zhu,

Guo

et al. 2023

Nanoscale

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“…154 Meanwhile, MSCs can differentiate into specific cell types needed for tissue regeneration. 155,156 Unfortunately, these cells have a limited lifespan, hindering their regenerative applications. Electrospinning technology has the potential to mimic ECM structures and has become a promising method for carrying cells and biological tissues.…”

Section: Biological Graftingmentioning

confidence: 99%

Electrospun fiber‐based immune engineering in regenerative medicine

Xu,

Saiding,

Zhou

et al. 2024

Smart Medicine

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Immune engineering, a burgeoning field within regenerative medicine, involves a spectrum of strategies to optimize the intricate interplay between tissue regenerative biomaterials and the host tissue. These strategies are applied across different types of biomaterials and various disease models, which encompasses finely modulating the immune response at the levels of immune cells and factors, aiming to mitigate adverse effects like fibrosis and persistent inflammation that may arise at the injury site and consequently promote tissue regeneration. With the continuous progress in electrospinning technology, the immunoregulatory capabilities of electrospun fibers have gained substantial attention over the years. Electrospun fibers, with their extracellular matrix‐like characteristics, high surface‐area‐to‐volume ratio, and reliable pharmaceutical compound capacity, have emerged as key players among tissue engineering materials. This review specifically focuses on the role of electrospun fiber‐based immune engineering, emphasizing their unique design strategies. Notably, electrospinning actively engages in immune engineering by modulating immune responses through four essential strategies: (i) surface modification, (ii) drug loading, (iii) physicochemical parameters, and (iv) biological grafting. This review presents a comprehensive overview of the intricate mechanisms of the immune system in injured tissues while unveiling the key strategies adopted by electrospun fibers to orchestrate immune regulation. Furthermore, the review explores the current developmental trends and limitations concerning the immunoregulatory function of electrospun fibers, aiming to drive the advancements in electrospun fiber‐based immune engineering to its full potential.

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“…Nowadays, engineered microbes have served as significant therapeutic agents for various therapeutic applications [113][114][115][116][117]. Several internal and external stimuli can activate the colonization and payload release of these administered bacteria [118,119].…”

Section: Engineered Bacteriamentioning

confidence: 99%

Emerging diagnostic and therapeutic technologies based on ultrasound-triggered biomaterials

et al. 2023

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Ultrasound (US) is a kind of acoustic waves with frequency higher than 20 kHz. Learning from the echo detection ability of bats and dolphins, scientists applied US for clinical imaging by sending out US waves and detecting echo with shifted intensities and frequencies from human tissue. US has long been played a critical role in noninvasive, real-time, low cost and portable diagnostic imaging. With the in-depth study of US in multidisciplinary fields, US and US-responsive materials has shown practical value in not only disease diagnosis, but also disease treatment. In this review, we introduce the lately proposed and representative US-responsive materials for biomedical applications, including diagnostic and therapeutic applications. We focused on US-mediated physiochemical therapies, such as sonodynamic therapy, high-intensity focused US ablation, sonothermal therapy, thrombolysis, etc., and US-controlled delivery of chemotherapeutics, gas, gene, protein, and bacteria. We also conclude the current challenges facing the clinical translation of the smart US-responsive materials and prospect future development of US medicine.

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Reprogramming stem cells in regenerative medicine

Cited by 27 publications

References 78 publications

Investigation of sponge medium for efficient concurrent tumor treating fields and radiotherapy for glioblastomas

Investigation of sponge medium for efficient concurrent tumor treating fields and radiotherapy for glioblastomas

Electrospun fiber‐based immune engineering in regenerative medicine

Emerging diagnostic and therapeutic technologies based on ultrasound-triggered biomaterials

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