Reprogramming the tumor microenvironment with biotechnology

Kim, Minjeong; Lee, Na Kyeong; Wang, Chi-Pin James; Lim, Jaesung; Byun, Min Ji; Kim, Tae-Hyung; Park, Wooram; Park, Dae-Hwan; Kim, Se-Na; Park, Chun Gwon

doi:10.1186/s40824-023-00343-4

Cited by 16 publications

(6 citation statements)

References 144 publications

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“…As the basis for tumor survival, the TME provides a material foundation for tumor proliferation, metastasis, and invasion. , The TME is a network surrounding tumor cells and consists of various types of cells. Blood vessels provide oxygen and nutrients and are responsible for removing waste products.…”

Section: Application Of Tumor Microenvironment Modulated Nanoplatform...mentioning

confidence: 99%

Advances in Nanoplatforms for Immunotherapy Applications Targeting the Tumor Microenvironment

Zhang,

Zhou,

et al. 2024

Mol. Pharmaceutics

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Cancer immunotherapy is a treatment method that activates or enhances the autoimmune response of the body to fight tumor growth and metastasis, has fewer toxic side effects and a longer-lasting efficacy than radiotherapy and chemotherapy, and has become an important means for the clinical treatment of cancer. However, clinical results from immunotherapy have shown that most patients lack responsiveness to immunotherapy and cannot benefit from this treatment strategy. The tumor microenvironment (TME) plays a critical role in the response to immunotherapy. The TME typically prevents effective lymphocyte activation, reducing their infiltration, and inhibiting the infiltration of effector T cells. According to the characteristic differences between the TME and normal tissues, various nanoplatforms with TME targeting and regulation properties have been developed for more precise regulation of the TME and have the ability to codeliver a variety of active pharmaceutical ingredients, thereby reducing systemic toxicity and improving the therapeutic effect of antitumor. In addition, the precise structural design of the nanoplatform can integrate specific functional motifs, such as surface-targeted ligands, degradable backbones, and TME stimulus-responsive components, into nanomedicines, thereby reshaping the tumor microenvironment, improving the body's immunosuppressive state, and enhancing the permeability of drugs in tumor tissues, in order to achieve controlled and stimulus-triggered release of load cargo. In this review, the physiological characteristics of the TME and the latest research regarding the application of TME-regulated nanoplatforms in improving antitumor immunotherapy will be described. Furthermore, the existing problems and further applications perspectives of TME-regulated platforms for cancer immunotherapy will also be discussed.

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Section: Application Of Tumor Microenvironment Modulated Nanoplatform...mentioning

confidence: 99%

Advances in Nanoplatforms for Immunotherapy Applications Targeting the Tumor Microenvironment

Zhang,

Zhou,

et al. 2024

Mol. Pharmaceutics

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show abstract

“…Immune system can exert its function of immune surveillance and immune response against tumor cells, which play crucial roles in proliferation, metastasis and treatment resistance of cancers 77 , 78 . Tumor immune microenvironment (TIME) consists of tumor, stromal and immune cells including adaptive and innate immune cells 79 . Current studies have showed remarkable enrichment of m7G regulators in biological processes in TIME, especially immune infiltration 6 .…”

Section: The Roles Of M7g Modification In Immune Cell Biologymentioning

confidence: 99%

M7G-related tumor immunity: novel insights of RNA modification and potential therapeutic targets

Han,

Huang,

et al. 2024

Int. J. Biol. Sci.

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RNA modifications play a pivotal role in regulating cellular biology by exerting influence over distribution features and molecular functions at the post-transcriptional level. Among these modifications, N7-methylguanosine (m7G) stands out as one of the most prevalent. Over recent years, significant attention has been directed towards understanding the implications of m7G modification. This modification is present in diverse RNA molecules, including transfer RNAs, messenger RNAs, ribosomal RNAs, and other noncoding RNAs. Its regulation occurs through a series of specific methyltransferases and m7G-binding proteins. Notably, m7G modification has been implicated in various diseases, prominently across multiple cancer types. Earlier studies have elucidated the significance of m7G modification in the context of immune biology regulation within the tumor microenvironment. This comprehensive review culminates in a synthesis of findings related to the modulation of immune cells infiltration, encompassing T cells, B cells, and various innate immune cells, all orchestrated by m7G modification. Furthermore, the interplay between m7G modification and its regulatory proteins can profoundly affect the efficacy of diverse adjuvant therapeutics, thereby potentially serving as a pivotal biomarker and therapeutic target for combinatory interventions in diverse cancer types.

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“…[16]. Table 1 is the summary of the infections documented in this literature that are resistant to antibiotics [17], [18].…”

Section: How Vaccines Can Help Prevent Antimicrobial Resistancementioning

confidence: 99%

Ascendancy of nanoparticles coated vaccines and their role in future of vaccinology

Sarwan,

Kumari,

Karn

et al. 2024

E3S Web Conf.

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Nanoparticles have emerged as a promising platform for the delivery of vaccines due to their unique properties, such as their small size, high surface area, and tunable surface properties. Coating these nanoparticles with antigens and adjuvants enhances their stability, immunogenicity, and targeting ability, thereby leading to improved vaccine efficacy. Vaccines have revolutionized the field of immunization, providing effective protection against numerous bacterial infections. This review paper expl ores the diverse strategies employed by vaccines to stimulate a robust immune response and confer immunity. Various vaccine types, including inactivated toxins (toxoids), live bacterial vaccines, live attenuated vaccines, and virus -like particles (VLPs), are investigated in terms of their mechanisms and suitability for different populations. While live bacterial vaccines and live attenuated vaccines have demonstrated efficacy, caution must be exercised when administering them to individuals with compromised immune systems. As an alternative, VLPs have emerged as a promising non-infectious option that closely resembles viral structures. VLPs offer advantages in terms of safety, cost-effectiveness, and their ability to elicit targeted immune responses, this could lead to significant breakthroughs in vaccine development. Ongoing research is dedicated to the development of vaccines targeting specific pathogens and combating antimicrobial resistance (AMR). Innovative approaches include mRNA-based vaccines, vaccines designed to target surface polysaccharides, vaccines that induce helper T cell responses, and vaccines against specific virulence factors. By understanding the mechanisms and potential applications of different vaccine types, researchers and healthcare professionals can contribute to the continued progress in immunization and protect individuals and communities from the burden of infectious diseases.

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Reprogramming the tumor microenvironment with biotechnology

Cited by 16 publications

References 144 publications

Advances in Nanoplatforms for Immunotherapy Applications Targeting the Tumor Microenvironment

Advances in Nanoplatforms for Immunotherapy Applications Targeting the Tumor Microenvironment

M7G-related tumor immunity: novel insights of RNA modification and potential therapeutic targets

Ascendancy of nanoparticles coated vaccines and their role in future of vaccinology

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