We study consistently the effects of magnetic field on hot and dense matter. In particular, we look for differences that arise due to assumptions that reproduce the conditions produced in particle collisions or astrophysical scenarios, such as in the core of fully evolved neutron stars (beyond the protoneutron star stage). We assume the magnetic field to be either constant or follow a profile extracted from general relativity calculations of magnetars and make use of two realistic models that can consistently describe chiral symmetry restoration and deconfinement to quark matter, the chiral mean field and the Polyakovloop extended Nambu-Jona-Lasinio models. We find that net isospin, net strangeness, and weak chemical equilibrium with leptons can considerably change the effects of temperature and magnetic fields on particle content and deconfinement in dense matter. We finish by discussing the possibility of experimentally detecting quark deconfinement in dense and/or hot matter and the possible role played by magnetic fields.