Repurposing Antibacterial AM404 As a Potential Anticancer Drug for Targeting Colorectal Cancer Stem-Like Cells

Ahmed, Mehreen; Jinks, Nicholas; Babaei‐Jadidi, Roya; Kashfi, Hossein; Castellanos-Uribe, Marcos; May, Sean; Mukherjee, Abhik; Nateri, Abdolrahman S.

doi:10.3390/cancers12010106

Cited by 17 publications

(18 citation statements)

References 64 publications

(116 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…FBXL5 is highly expressed in colon cancer, and its high expression has been associated with reduced overall survival and exaggerated clinicopathologic characteristics in colon cancer patients. AM404, a metabolite of acetaminophen with antibacterial activity, was found to suppress the expression of FBXL5 and to inhibit the dedifferentiation and acquisition of stem-like properties in organoids of colon cancer patients, suggesting that this agent might have potential as an anticancer drug [143]. It thus appears that FBXL5 positively or negatively regulates carcinogenesis in a tissue-dependent manner.…”

Section: Fbxl5mentioning

confidence: 99%

F-Box Proteins and Cancer

Yumimoto

Yamauchi

Nakayama

2020

Cancers

View full text Add to dashboard Cite

Controlled protein degradation is essential for the operation of a variety of cellular processes including cell division, growth, and differentiation. Identification of the relations between ubiquitin ligases and their substrates is key to understanding the molecular basis of cancer development and to the discovery of novel targets for cancer therapeutics. F-box proteins function as the substrate recognition subunits of S-phase kinase-associated protein 1 (SKP1)−Cullin1 (CUL1)−F-box protein (SCF) ubiquitin ligase complexes. Here, we summarize the roles of specific F-box proteins that have been shown to function as tumor promoters or suppressors. We also highlight proto-oncoproteins that are targeted for ubiquitylation by multiple F-box proteins, and discuss how these F-box proteins are deployed to regulate their cognate substrates in various situations.

show abstract

Section: Fbxl5mentioning

confidence: 99%

F-Box Proteins and Cancer

Yumimoto

Yamauchi

Nakayama

2020

Cancers

View full text Add to dashboard Cite

show abstract

“…Additionally, the living biobank of bladder cancer organoids from patients not only retained tumor histopathology and gene mutations but also proceeded the tumor evolution in the process of passage [ 70 ]. Therefore, long-term cancer organoids were appropriate for high-throughput drug screening and individualized therapy [ 71 ].…”

Section: Types Of Cancer Organoid Model Used For Drug Screeningmentioning

confidence: 99%

Drug screening model meets cancer organoid technology

Liu

Qin

Huang

et al. 2020

Translational Oncology

View full text Add to dashboard Cite

Tumor organoids inherit the genomic and molecular characteristics of the donor tumor, which not only bridge the gap between genome and phenotype but also circumvent the disadvantages such as genetic information change by using 2D cell lines and the mouse-specific tumor evolution in patient-derived xenograft (PDX). So, cancer organoid has been widely applied to preclinical drug evaluation, biomarker identification, biological research, and individualized therapy. Besides, cancer organoid can be preserved, resuscitated, passed infinitely, and mechanically cultured on a chip for drug screening; it has become one of the partial models for low/high-throughput drug screening in the preclinical trial in vitro. Therefore, this review presents the recent developments of tumor organoids for drug screening, which will introduce from four aspects, including the stability/credibility, types, application, deficiency and prospect of the tumor organoids model for drug screening.

show abstract

“…It exerts anticancer activity by suppressing oncogenic FBXL5 in colorectal cancer cells to regulate the PTEN/PI3K/AKT signal pathway and HIF-1 transcriptional activity which then results in colon cancer death. To further confirm this result, AM404 is sensitive to FBXL5 -knockout cells and causes further additive effects by inhibiting cell migration 109 . Salbutamol ( Fig.…”

Section: Molecular Mechanisms Repurposing Non-oncology Drugs In Cance...mentioning

confidence: 75%