Repurposing povidone-iodine to reduce the risk of SARS-CoV-2 infection and transmission: a narrative review

Lim, Nicole-Ann; Teng, Ooiean; Ng, Chester Yan Hao; Bao, Lena X Y; Tambyah, Paul Anantharajah; Quek, Amy May Lin; Seet, Raymond C.S.

doi:10.1080/07853890.2022.2076902

Cited by 20 publications

(11 citation statements)

References 94 publications

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“…Previous studies have reported several anti-SARS-CoV-2 applications to prevent primary infection in airway [reviewed in ( Alqathama et al, 2022 , Ivanova et al, 2022 , Lim et al, 2022 , Xi et al, 2021 )]. The underlying anti-viral mechanisms of these new drugs, commercial products, and formulations are varied but at least two major strategies have been hypothesized and investigated.…”

Section: Discussionmentioning

confidence: 99%

“…Recently there has been renewed interest in the application of PVI in SARS-CoV-2 pandemic, especially the practice in the community. Nicole-Ann Lim et al ( Lim et al, 2022 ) reviewed relevant clinical trials till June 3rd 2021 and concluded that use of PV-I in mouth route was a probable candidate of non-pharmacological interventions in combatingSARS-CoV-2 infection.…”

Section: Discussionmentioning

confidence: 99%

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Functionalized protein microparticles targeting hACE2 as a novel preventive strategy for SARS-CoV-2 infection

Huang

Zhu

et al. 2023

International Journal of Pharmaceutics

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Functionalized protein microparticles targeting hACE2 as a novel preventive strategy for SARS-CoV-2 infection

Huang

Zhu

et al. 2023

International Journal of Pharmaceutics

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“…PVP‐I and octenidine are both topical antiseptics which are considered safe and efficient, and widely used for presurgical skin disinfection 4 . PVP‐I is an iodophor consisting of a complex of iodine and povidone which exerts its antimicrobial effects by effectively releasing iodine (I 2 , PVP·nHI 3 , and I 3 −) when in an aqueous solution state 5 . Octenidine is a cationic antiseptic with the activity against both gram‐positive and gram‐negative bacteria 6 .…”

Section: Discussionmentioning

confidence: 99%

Irritant contact dermatitis and nail loss from the combined use of topical antiseptics

Ma,

Li,

et al. 2023

Contact Dermatitis

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“…6−9 As for virus inactivation, I 2 solution can rapidly inactivate SARS-CoV-2 in a brief contact time. 10,11 The antiviral effect of I 2 is directly related to its content. 12 Moreover, I 2 administration in the URT is deemed to be relatively safe.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular Structure of the β-Cyclodextrin Metal–Organic Framework Optimizes Iodine Stability and Its Co-delivery with l-Menthol for Antibacterial Applications

Zhao,

Li,

Guo

et al. 2024

ACS Appl. Mater. Interfaces

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The spread of upper respiratory tract (URT) infections harms people's health and causes social burdens. Developing targeted treatment strategies for URT infections that exhibit good biocompatibility, stability, and strong antimicrobial effects remains challenging. The dual antimicrobial and antiviral effects of iodine (I 2 ) in combination with the cooling sensation of L-menthol in the respiratory tract can simultaneously alleviate URT inflammation symptoms. However, as both I 2 and L-menthol are volatile, addressing stability issues is crucial. In this study, a potassium iodide β-cyclodextrin metal−organic framework [β-CD-POF(I)] with appropriate particle size was used to coload and deliver I 2 and L-menthol. Primarily, β-CD-POF(I) was employed as the most efficient carrier to significantly enhance the stability of I 2 , surpassing any other known protection strategies in the pharmaceutical field (CD complexations, PVP conjugations, and cadexomer iodine). The mechanism underlying the improvement in stability of I 2 by β-CD-POF(I) was investigated through scanning electron microscopy with energy-dispersive X-ray spectroscopy, Xray photoelectron spectroscopy, Raman spectroscopy, and molecular docking. The results revealed that the key processes involved in improving stability were the inclusion of I 2 by β-CD cavities in β-CD-POF(I) and the formation of polyiodide anion between iodine ions and I 2 . Furthermore, the potential of β-CD-POF(I) to load and deliver drugs was validated, and coloading of L-menthol and I 2 demonstrated reliable stability. β-CD-POF(I) achieved a rate of URT deposition ≥95% in vitro, and the combined antibacterial effects of coloaded I 2 and L-menthol was better than I 2 or PVP-I alone, with no irritation noted following URT administration in rabbits. Therefore, the stable coloading of drugs by β-CD-POF(I), leading to enhanced antimicrobial effects, provides a new strategy for treating URT infections.

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Repurposing povidone-iodine to reduce the risk of SARS-CoV-2 infection and transmission: a narrative review

Cited by 20 publications

References 94 publications

Functionalized protein microparticles targeting hACE2 as a novel preventive strategy for SARS-CoV-2 infection

Functionalized protein microparticles targeting hACE2 as a novel preventive strategy for SARS-CoV-2 infection

Irritant contact dermatitis and nail loss from the combined use of topical antiseptics

Supramolecular Structure of the β-Cyclodextrin Metal–Organic Framework Optimizes Iodine Stability and Its Co-delivery with l-Menthol for Antibacterial Applications

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