Repurposing the anthelmintic praziquantel to treat psoriasis

Abstract

Background and Purpose The anthelmintic drug praziquantel has been used as a standard treatment for schistosomiasis for over 40 years. This study aimed to repurpose praziquantel to treat psoriasis. Experimental Approach Psoriasis‐like skin inflammation was induced in mice (C57 and Balb/C) by topical application of imiquimod or intradermal injection of recombinant IL‐23. Praziquantel was either orally or topically administered during the psoriasis induction period. Key Results Mice treated with either oral or topical praziquantel exhibited markedly improved psoriasiform skin symptoms when compared with control mice, as judged by disease severity score, epidermal thickening, inflammatory cell infiltration and spleen size. Flow cytometric analysis of infiltrating immune cells from mouse skin displayed reduced infiltration of Th17 cells. In vitro experiments revealed that praziquantel inhibited STAT3 phosphorylation and RORγt expression in splenic CD4+ T‐cells. Praziquantel also decreased STAT3 phosphorylation in HEK‐A/F cells. Down‐regulation of STAT3 phosphorylation in these cells accounts for the decreased number of Th17 cells and keratinocytes. Conclusion and Implications These results provide the first preclinical evidence that praziquantel may effectively treat psoriasis, and suggest that praziquantel alleviates symptoms in mice by inhibiting STAT3 phosphorylation, thereby suppressing Th17 immune responses.

Dietary supplementation with α-ionone alleviates chronic UVB exposure-induced skin photoaging in mice

“…C57BL/6 mice are commonly used and well-known animal models for skin studies. 14,18,19 And the use of UVB light to induce experimental photoaging in mice is a widely accepted method due to its ability to mimic the effects of chronic UV exposure in humans. 20,21 The maximum dose of UVB radiation applied in our study was 300 mJ cm −2 , which is approximately equivalent to the UVB dose received during 15 minutes of sun exposure in Beijing in May, as computed using the solar calculator developed by Diffey.…”

Anti-angiogenic and anti-proliferative activity of ziziphus leaf extract as a novel potential therapeutic agent for reducing hepatic injury in experimental hamster schistosomiasis

“…We have found no previous study that evaluated the anti-proliferative activity of ZLE and praziquantel in Schistosoma-mansoni-induced liver proliferation. However, Hao et al demonstrated that praziquantel has an antiproliferative effect during the treatment of psoriasis in mice by inhibiting STAT3 phosphorylation, thereby suppressing Th17 immunity [45]. In addition, many studies highlight the anti-proliferative potential of ZLE in cancer patients.…”