Repurposing the antihistamine drug bilastine as an anti-cancer metallic drug entity: synthesis and single-crystal X-ray structure analysis of metal-based bilastine and phen [Co(ii), Cu(ii) and Zn(ii)] tailored anticancer chemotherapeutic agents against resistant cancer cells

Abstract

Bilastine, 2-(4-(2-(4-(1-2-ethoxyethyl)-1H-benzo[d]imidazole-2-yl)-piperidin-1-yl)-ethyl)-phenyl)-2-methylpropanoic acid, BLA is an active antihistamine drug. With the idea of repurposing drugs from existing pool of ‘active’ pharmaceutical ingredients, therapeutic potency of bilastine as an anticancer agent...