Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment

Li, Wen-Ning; Zhang, Shi-Jiao; Feng, Jia-Qing; Jin, Weilin

doi:10.3390/cancers14112608

Cited by 12 publications

(8 citation statements)

References 110 publications

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“…Targeting the TME represents a promising tumour therapy strategy [ 3 ]. In recent years, TME classification based on the functional TME specialisations has been gradually perfected and suggests the potential for combination therapy [ 4 , 5 ]. Recently, the interaction of cancer-associated fibroblasts (CAFs), mesenchymal stem cells (MSCs), and cancer stem cells (CSCs) with immune cells has received increasing attention, so we further subdivided the TME into nine specialised TMEs to better characterise the state of immune cells in the TME.…”

Section: Introductionmentioning

confidence: 99%

NK cells are never alone: crosstalk and communication in tumour microenvironments

Zhou

Lu²,

Liu

et al. 2023

Mol Cancer

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Immune escape is a hallmark of cancer. The dynamic and heterogeneous tumour microenvironment (TME) causes insufficient infiltration and poor efficacy of natural killer (NK) cell-based immunotherapy, which becomes a key factor triggering tumour progression. Understanding the crosstalk between NK cells and the TME provides new insights for optimising NK cell-based immunotherapy. Here, we present new advances in direct or indirect crosstalk between NK cells and 9 specialised TMEs, including immune, metabolic, innervated niche, mechanical, and microbial microenvironments, summarise TME-mediated mechanisms of NK cell function inhibition, and highlight potential targeted therapies for NK-TME crosstalk. Importantly, we discuss novel strategies to overcome the inhibitory TME and provide an attractive outlook for the future.

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Section: Introductionmentioning

confidence: 99%

NK cells are never alone: crosstalk and communication in tumour microenvironments

Zhou

Lu²,

Liu

et al. 2023

Mol Cancer

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“…The microbial microenvironment is an emerging specialized microenvironment that delineates a landscape composed of intratumor microbiota, intestinal microbiota, and their metabolites 5 , 185 . Intestinal microbiota plays an indispensable role in cholesterol metabolism.…”

Section: Cholesterol Metabolism and The Tmementioning

confidence: 99%

“…The complex TME was previously divided into six specialized microenvironments 4 . Recently, this classification has been expanded to include seven specialized microenvironments: hypoxic niche, immune microenvironment, metabolism microenvironment, acidic niche, innervated niche, mechanical microenvironment, and microbial microenvironment 2 , 5 . These specialized microenvironments interact with each other to form a dynamic tumor ecosystem.…”

Section: Introductionmentioning

confidence: 99%

Cholesterol metabolism in tumor microenvironment: cancer hallmarks and therapeutic opportunities

Jiang,

Jin,

2024

Int. J. Biol. Sci.

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Cholesterol is crucial for cell survival and growth, and dysregulation of cholesterol homeostasis has been linked to the development of cancer. The tumor microenvironment (TME) facilitates tumor cell survival and growth, and crosstalk between cholesterol metabolism and the TME contributes to tumorigenesis and tumor progression. Targeting cholesterol metabolism has demonstrated significant antitumor effects in preclinical and clinical studies. In this review, we discuss the regulatory mechanisms of cholesterol homeostasis and the impact of its dysregulation on the hallmarks of cancer. We also describe how cholesterol metabolism reprograms the TME across seven specialized microenvironments. Furthermore, we discuss the potential of targeting cholesterol metabolism as a therapeutic strategy for tumors. This approach not only exerts antitumor effects in monotherapy and combination therapy but also mitigates the adverse effects associated with conventional tumor therapy. Finally, we outline the unresolved questions and suggest potential avenues for future investigations on cholesterol metabolism in relation to cancer.

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“…Cancer targeting ligands include cell organelle targeting, cell membrane targeting, and multitargeting. The different targeting moieties include antibodies 210,211 , aptamers 212 , peptides 213 , saccharides 214 , proteins 215 and vitamins 216 . For example, a previous study has conjugated antiHER2/neu mAb on the surfaces of MSNs to target breast cancer cells 217 .…”

Section: Active Targetingmentioning

confidence: 99%

Pore-engineered nanoarchitectonics for cancer therapy

Sutrisno

Ariga

2023

NPG Asia Mater

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Nanoarchitectonics describes the integration of nanotechnology with other fields as a postnanotechnology concept that elevates it to material science. Based on this fundamental principle, we address pore-engineered nanoarchitectonics with application targets for cancer therapy by combining basic descriptions and exemplifying therapy applications in this review. The initial two sections briefly summarize pore-engineered nanoarchitectonics basics according to classification based on (i) material porosity and (ii) material composition. Afterward, the main application-oriented section—designing mesoporous material for cancer therapy—is presented. Various types of drug delivery systems, including mesoporous nanoparticles as nanocarriers, endogenous stimuli-responsive drug delivery, exogenous stimuli-responsive drug delivery, and targeted drug delivery, are described. Importantly, the clinical translation of mesoporous materials is further discussed. Mesoporous materials are unique nanoparticles that offer a network of cavities as vehicles for drug nanocarriers. Regarding the developments that allow mesoporous nanoparticles to be broadly used in clinical settings, there are several challenges that should be solved for their clinical application. From a clinical perspective, there are tremendous processes in the development of mesoporous materials.

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Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment

Cited by 12 publications

References 110 publications

NK cells are never alone: crosstalk and communication in tumour microenvironments

NK cells are never alone: crosstalk and communication in tumour microenvironments

Cholesterol metabolism in tumor microenvironment: cancer hallmarks and therapeutic opportunities

Pore-engineered nanoarchitectonics for cancer therapy

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