Requirement for Msh6, but Not for Swi4 (Msh3), in Msh2-Dependent Repair of Base-Base Mismatches and Mononucleotide Loops in <i>Schizosaccharomyces pombe</i>

Tornier, Carine; Bessone, Stéphanie; Varlet, Isabelle; Rudolph, Claudia; Darmon, Michel; Fleck, Oliver

doi:10.1093/genetics/158.1.65

Cited by 18 publications

(2 citation statements)

References 56 publications

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“…Sc. pombe contains only one MutL homolog (Mlh1 Sp -Pms1 Sp ) [100]. Thus, MutSα Sp and MutLα Sp should be sufficient for a functional MMR machinery in fission yeast, as it seems to be the case in Drosophila and Caenorhabditis.…”

Section: Mmr In Yeastmentioning

confidence: 99%

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DNA Repair in Haploid Context

Mourrain

Boissonneault

2021

IJMS

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DNA repair is a well-covered topic as alteration of genetic integrity underlies many pathological conditions and important transgenerational consequences. Surprisingly, the ploidy status is rarely considered although the presence of homologous chromosomes dramatically impacts the repair capacities of cells. This is especially important for the haploid gametes as they must transfer genetic information to the offspring. An understanding of the different mechanisms monitoring genetic integrity in this context is, therefore, essential as differences in repair pathways exist that differentiate the gamete’s role in transgenerational inheritance. Hence, the oocyte must have the most reliable repair capacity while sperm, produced in large numbers and from many differentiation steps, are expected to carry de novo variations. This review describes the main DNA repair pathways with a special emphasis on ploidy. Differences between Saccharomyces cerevisiae and Schizosaccharomyces pombe are especially useful to this aim as they can maintain a diploid and haploid life cycle respectively.

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Section: Mmr In Yeastmentioning

confidence: 99%

“…Sc. pombe possesses four MutS homologs (Msh1 Sp , Msh2 Sp , Swi4 Sp , Msh6 Sp ) [100]. MutSα Sp (Msh2 Sp -Msh6 Sp ) is sufficient to support Sc.…”

Section: Mmr In Yeastmentioning

confidence: 99%

DNA Repair in Haploid Context

Mourrain

Boissonneault

2021

IJMS

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DNA mismatch repair and mutation avoidance pathways

Marti

Kunz

Fleck

2002

Journal Cellular Physiology

Self Cite

224

186

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Unpaired and mispaired bases in DNA can arise by replication errors, spontaneous or induced base modi®cations, and during recombination. The major pathway for correction of mismatches arising during replication is the MutHLS pathway of Escherichia coli and related pathways in other organisms. MutS initiates repair by binding to the mismatch, and activates together with MutL the MutH endonuclease, which incises at hemimethylated dam sites and thereby mediates strand discrimination. Multiple MutS and MutL homologues exist in eukaryotes, which play different roles in the mismatch repair (MMR) pathway or in recombination. No MutH homologues have been identi®ed in eukaryotes, suggesting that strand discrimination is different to E. coli. Repair can be initiated by the heterodimers MSH2-MSH6 (MutSa) and MSH2-MSH3 (MutSb). Interestingly, MSH3 (and thus MutSb) is missing in some genomes, as for example in Drosophila, or is present as in Schizosaccharomyces pombe but appears to play no role in MMR. MLH1-PMS1 (MutLa) is the major MutL homologous heterodimer. Again some, but not all, eukaryotes have additional MutL homologues, which all form a heterodimer with MLH1 and which play a minor role in MMR. Additional factors with a possible function in eukaryotic MMR are PCNA, EXO1, and the DNA polymerases d and E. MMR-independent pathways or factors that can process some types of mismatches in DNA are nucleotide-excision repair (NER), some base excision repair (BER) glycosylases, and the¯ap endonuclease FEN-1. A pathway has been identi®ed in Saccharomyces cerevisiae and human that corrects loops with about 16 to several hundreds of unpaired nucleotides. Such large loops cannot be processed by MMR.

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Current Awareness

2001

Yeast

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In order to keep subscribers up‐to‐date with the latest developments in their field, this current awareness service is provided by John Wiley & Sons and contains newly‐published material on yeasts. Each bibliography is divided into 10 sections. 1 Books, Reviews & Symposia; 2 General; 3 Biochemistry; 4 Biotechnology; 5 Cell Biology; 6 Gene Expression; 7 Genetics; 8 Physiology; 9 Medical Mycology; 10 Recombinant DNA Technology. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted. (4 weeks journals ‐ search completed 11th July 2001)

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Requirement for Msh6, but Not for Swi4 (Msh3), in Msh2-Dependent Repair of Base-Base Mismatches and Mononucleotide Loops in Schizosaccharomyces pombe

Cited by 18 publications

References 56 publications

DNA Repair in Haploid Context

DNA Repair in Haploid Context

DNA mismatch repair and mutation avoidance pathways

Current Awareness

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