2005
DOI: 10.4049/jimmunol.175.8.5524
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Requirement for Neutralizing Antibodies to Control Bone Marrow Transplantation-Associated Persistent Viral Infection and to Reduce Immunopathology

Abstract: Bone marrow transplantation (BMT) is commonly used in the treatment of leukemia, however its therapeutic application is partly limited by the high incidence of associated opportunistic infections. We modeled this clinical situation by infecting mice that underwent BMT with lymphocytic choriomeningitis virus (LCMV) and investigated the potential of immunotherapeutic strategies to counter such infections. All mice that received BMT survived LCMV infection and developed a virus carrier status. Immunotherapy by ad… Show more

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“…Virus titers were measured using focus-forming assays as previously described. 49 Mice were infected with 2 Â 10 6 PFUs LCMV-WE. For bacterial infections, recombinant Listeria expressing the LCMV-GP33 epitope was used.…”
Section: Methodsmentioning
confidence: 99%
“…Virus titers were measured using focus-forming assays as previously described. 49 Mice were infected with 2 Â 10 6 PFUs LCMV-WE. For bacterial infections, recombinant Listeria expressing the LCMV-GP33 epitope was used.…”
Section: Methodsmentioning
confidence: 99%