Requirement of a Compartmentalization for NADPH Oxidizing Site and Peroxidase-H₂O₂in the Thyroid Iodinating System

Abstract

In this study, it is shown that NADPH iodination occurs in a thyroid peroxidase-H2O2 system in presence of thyroglobulin, the normal iodination substrate. Previous data suggested that thyroid H2O2 generation is a NADPH-dependent system. Present results support the concept of a compartmentalization of the sites of NADPH oxidation and peroxidasic iodination.