2020
DOI: 10.1101/2020.04.09.033373
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Requirement of DNMT1 to orchestrate epigenomic reprogramming during NPM-ALK driven T cell lymphomagenesis

Abstract: Phone: +43 1 40400 22390The authors declare no potential conflicts of interest.Word count: Abstract 150, Statement of significance 52, Main text 4881, Methods 2072. ABSTRACTMalignant transformation depends on genetic and epigenetic events that result in a burst of deregulated gene expression and chromatin changes. To dissect the sequence of events in this process, we used a T cell-specific lymphoma model based on the human oncogenic NPM-ALK translocation. We find that transformation of T cells shifts thymic ce… Show more

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