1986
DOI: 10.1002/eji.1830161226
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Requirement of H‐2 heterozygosity for autoimmunity in (NZB × NZW)F1 hybrid mice

Abstract: In the F1 hybrid of autoimmune New Zealand Black (NZB) and phenotypically normal New Zealand White (NZW) mice, there occurs a severe systemic lupus erythematosus (SLE)-like autoimmune disease more fulminant than that found in the parental NZB mice. To determine the role of the H-2 complex in the pathogenesis of autoimmune disease of the (NZB X NZW)F1 hybrid, we developed H-2-congenic NZB (NZB.H-2z) and NZW (NZW.H-2d) strains, and compared the degree of autoimmune features between congenic H-2d/H-2d and H-2z/H-… Show more

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Cited by 91 publications
(2 citation statements)
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“…MHC H-2 d / z heterozygosity (H-2 d of NZB and H-2 z of NZW mice) promotes lupus disease, as congenic H-2 d / d and H-2 z / z homozygous crosses do not develop severe disease [172, 173]. On the other hand, Zhang and coworkers found that H-2A d / d homozygous (NZB × NZW) F1 mice lacking H-2E molecules developed severe SLE similar to that seen in wild-type F1 mice, whereby the effect of H-2E is greatly influenced by the haplotype of H-2A molecules [174].…”
Section: How Is Lupus Erythematosus Influenced By the Mhc?mentioning
confidence: 99%
“…MHC H-2 d / z heterozygosity (H-2 d of NZB and H-2 z of NZW mice) promotes lupus disease, as congenic H-2 d / d and H-2 z / z homozygous crosses do not develop severe disease [172, 173]. On the other hand, Zhang and coworkers found that H-2A d / d homozygous (NZB × NZW) F1 mice lacking H-2E molecules developed severe SLE similar to that seen in wild-type F1 mice, whereby the effect of H-2E is greatly influenced by the haplotype of H-2A molecules [174].…”
Section: How Is Lupus Erythematosus Influenced By the Mhc?mentioning
confidence: 99%
“…These genes are located in chromosome 17. Several studies demonstrated a strong association of H2d/z heterozygosity with the development of SLE, indicating a co-dominant contribution from each strain, H2d from NZB and H2z from NZW [64].…”
Section: Susceptibility Loci For Systemic Lupus On Chromosome 17: Lbwmentioning
confidence: 99%