Requirement ofabdominal-AandAbdominal-Bin the developing genitalia ofDrosophilabreaks the posterior downregulation rule

Foronda, David; Estrada, Beatriz; Navas, Luis F. de; Sánchez‐Herrero, Ernesto

doi:10.1242/dev.02173

Cited by 43 publications

(34 citation statements)

References 96 publications

(121 reference statements)

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“…Abd-B and Spalt proteins are both deployed in broad domains that include the posterior lobe (Figure 4G–H; Figure S4I–J), consistent with severe genital defects in Abd-B (Estrada and Sánchez-Herrero, 2001; Foronda et al, 2006) and spalt mutants (Dong et al, 2003). In contrast, Empty spiracles (Ems), named for its spiracle phenotype (Jürgens et al, 1984), is expressed in a restricted genital pattern similar to Poxn (Figure 4I; Figure S4K).…”

Section: Resultssupporting

confidence: 55%

Co-option of an Ancestral Hox-Regulated Network Underlies a Recently Evolved Morphological Novelty

et al. 2015

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SUMMARY The evolutionary origins of complex morphological structures such as the vertebrate eye or insect wing remain one of the greatest mysteries of biology. Recent comparative studies of gene expression imply that new structures are not built from scratch, but rather form by co-opting preexisting gene networks. A key prediction of this model is that upstream factors within the network will activate their preexisting targets (i.e. enhancers) to form novel anatomies. Here, we show how a recently derived morphological novelty present in the genitalia of D. melanogaster employs an ancestral Hox-regulated network deployed in the embryo to generate the larval posterior spiracle. We demonstrate how transcriptional enhancers and constituent transcription factor binding sites are used in both ancestral and novel contexts. These results illustrate network co-option at the level of individual connections between regulatory genes, and highlight how morphological novelty may originate through the co-option of networks controlling seemingly unrelated structures.

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Section: Resultssupporting

confidence: 55%

Co-option of an Ancestral Hox-Regulated Network Underlies a Recently Evolved Morphological Novelty

et al. 2015

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“…Together, these findings suggest that size and shape of genital structures and their component parts are developmentally and genetically decoupled enough to evolve independent of each other. Unfortunately, the developmental and genetic mechanisms underlying the regulation of genital form are relatively poorly understood in insects [10], [43], [46] though what is known suggests that many of the same developmental genetic processes that take place in appendages such as legs and mouthparts also contribute to genital differentiation [47]–[49]. If correct, this suggests that local, segment specific regulation of differential growth and differentiation must underlay genitalic development and evolution, rather that genitalia-specific developmental processes.…”

Section: Discussionmentioning

confidence: 99%

Shape - but Not Size - Codivergence between Male and Female Copulatory Structures in Onthophagus Beetles

et al. 2011

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Genitalia are among the fastest evolving morphological traits in arthropods. Among the many hypotheses aimed at explaining this observation, some explicitly or implicitly predict concomitant male and female changes of genital traits that interact during copulation (i.e., lock and key, sexual conflict, cryptic female choice and pleiotropy). Testing these hypotheses requires insights into whether male and female copulatory structures that physically interact during mating also affect each other's evolution and patterns of diversification. Here we compare and contrast size and shape evolution of male and female structures that are known to interact tightly during copulation using two model systems: (a) the sister species O. taurus (1 native, 3 recently established populations) and O. illyricus, and (b) the species-complex O. fracticornis-similis-opacicollis. Partial Least Squares analyses indicated very little to no correlation between size and shape of copulatory structures, both in males and females. Accordingly, comparing shape and size diversification patterns of genitalia within each sex showed that the two components diversify readily - though largely independently of each other - within and between species. Similarly, comparing patterns of divergence across sexes showed that relative sizes of male and female copulatory organs diversify largely independent of each other. However, performing this analysis for genital shape revealed a signature of parallel divergence. Our results therefore suggest that male and female copulatory structures that are linked mechanically during copulation may diverge in concert with respect to their shapes. Furthermore, our results suggest that genital divergence in general, and co-divergence of male and female genital shape in particular, can evolve over an extraordinarily short time frame. Results are discussed in the framework of the hypotheses that assume or predict concomitant evolutionary changes in male and female copulatory organs.

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“…However, in the development of male and female sex organs and appendages, BX-C genes cooperatively interact with one another (21,22). To examine the relationship between BX-C genes, the ABD-B binding site within the abd-A promoter region was analyzed by employing EMSA (Fig.…”

Section: Resultsmentioning

confidence: 99%

Sequence-specific interaction between ABD-B homeodomain and castor gene in Drosophila

Kim

Yoo

2014

BMB Reports

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We have examined the effect of bithorax complex genes on the expression of castor gene. During the embryonic stages 12-15, both Ultrabithorax and abdominal-A regulated the castor gene expression negatively, whereas Abdominal-B showed a positive correlation with the castor gene expression according to real-time PCR. To investigate whether ABD-B protein directly interacts with the castor gene, electrophoretic mobility shift assays were performed using the recombinant ABD-B homeodomain and oligonucleotides, which are located within the region 10 kb upstream of the castor gene. The results show that ABD-B protein directly binds to the castor gene specifically. ABD-B binds more strongly to oligonucleotides containing two 5'-TTAT-3' canonical core motifs than the probe containing the 5'-TTAC-3' motif. In addition, the sequences flanking the core motif are also involved in the protein-DNA interaction. The results demonstrate the importance of HD for direct binding to target sequences to regulate the expression level of the target genes. [BMB Reports 2014; 47(2): 92-97]

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Requirement ofabdominal-AandAbdominal-Bin the developing genitalia ofDrosophilabreaks the posterior downregulation rule

Cited by 43 publications

References 96 publications

Co-option of an Ancestral Hox-Regulated Network Underlies a Recently Evolved Morphological Novelty

Co-option of an Ancestral Hox-Regulated Network Underlies a Recently Evolved Morphological Novelty

Shape - but Not Size - Codivergence between Male and Female Copulatory Structures in Onthophagus Beetles

Sequence-specific interaction between ABD-B homeodomain and castor gene in Drosophila

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