REQUIREMENTS FOR THROMBORESISTANCE OF SURFACE‐HEPARINIZED MATERIALSa

Olsson, Per; Larm, Olle; Larsson, Rolf; Le, Lins; Nilsson, Evalill; Swedenborg, Jesper

doi:10.1111/j.1749-6632.1983.tb35210.x

Cited by 31 publications

(10 citation statements)

References 16 publications

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“…Die Heparinbeschichtung der intralurninalen Oberfläche wird von C'ar,neda (Schweden) durchgefuhrt. Heparin vom Schwein wird dabei eine kovalente Bindung mit Endpunktfixation an das Polyurethan des Interpositionskonnektors gebunden (7,8,12,13).…”

Section: Materials Und Methode Ergebnisseunclassified

Interpositionskonnektoren mit Heparinbeschichtung für den Gefäßanschluß mikrochirurgischer Gewebelappen

Mayer

Kretschmer²,

Gunzenhäusser³

1992

Laryngo-Rhino-Otol

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The intraluminal surface of interposition connectos which are introduced for the quick vascular connection of microsurgical free flaps was coated by heparin. This heparin coating proved to be stable at the polyurethane wall until the intraluminal surface of the interposition connectors with a length of 15 mm was coated by a layer of endothelial cells. 90% of the experimental venous connections didn't show a thrombus formation and were open for the blood flow 10 days postoperatively. The experimental free flaps which were connected by this way had survived 21 days postoperatively and showed a regular healing.

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Section: Materials Und Methode Ergebnisseunclassified

Interpositionskonnektoren mit Heparinbeschichtung für den Gefäßanschluß mikrochirurgischer Gewebelappen

Mayer

Kretschmer²,

Gunzenhäusser³

1992

Laryngo-Rhino-Otol

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“…Basic studies, such as the primate model previously described, may provide useful information on the endogenous disposition of these agents. 47…”

Section: Pharmacokinetic Studies In Primatesmentioning

confidence: 99%

A Primate Model (Macaca Mulatta) to Study the Pharmacokinetics of Heparin and Its Fractions

Fareed¹,

Kumar²,

Rock³

et al. 1985

Semin Thromb Hemost

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We have extensively studied the hemostatic parameters and the responses to the anticoagulant action of heparin and its fractions in the primate model (M. mulatta) and found these to be identical to those obtained in humans. The functional properties of antithrombin III, alpha 2-antiplasmin, and platelet factor 4 were also identical to humans in amidolytic and coagulant assays. Human antibodies against FPA, B beta 15-42 peptide, platelet factor 4, and thromboxane B2 reacted with the primate antigen, and assays were developed to measure these parameters in primates. Infusion of activated prothrombin complex concentrates (more than 100 U/kg/day) on a continual basis up to 3 days resulted in a hypercoagulable state manifested by an elevation of FPA, thromboxane B2, and changes in the thrombelastographic patterns. Similarly, infusion of homologous primate serum also resulted in a hypercoagulable state, as was evident by a sharp increase in the FPA levels. The antithrombotic effects of intravenous and subcutaneous administration of heparin, its low molecular fraction, and their constituents were studied after intravenous and subcutaneous injections. The low molecular weight fractions showed the most effective antithrombotic effects, whereas somewhat milder protection was observed with the starting material and highly anionic fraction. The prolongation of global tests, such as the APTT, TT, and changes in the thromboelastogram did not correlate with the reduction in the blood markers of hypercoagulable state. A modified simplate bleeding time method was used to study the effect of heparin and its fractions on the bleeding profile of heparin fractions. The components of fibrinolytic systems were also measurable in both the clot-based and amidolytic methods to predict the profibrinolytic actions of heparin fractions in its mode. These studies suggest that plasma markers, such as the platelet release proteins, products of thrombin activation, and prostaglandin metabolites, may provide better indices in the monitoring of the antithrombotic actions of newer heparins and antithrombotic drugs. Studies suggest that the pathophysiologic responses after a thrombogenic trigger in the primate model are close to humans, and drug modulation of these may provide relevant clinical information. This model provides the most similar preclinical model to study the actions of heparin fractions.

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“…Platelet aggregation and thrombus formation on the outer surfaces of vascular catheters, and their potential clinical implications have been the object of detailed experimental and clinical studies (3,(6)(7)(8)(9).…”

Section: Descmentioning

confidence: 99%

Coronary Thromboembolism with Fatal Outcome Following Coronary Angiography

Mogensen

Szamosi

Törnell

1985

Journal of Internal Medicine

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A case of fatal thromboembolic occlusion of the left coronary artery at selective coronary arteriography is described. The course of events and the findings at autopsy suggest that thrombotic material was deposited on one intravascular catheter and transferred to a second catheter inserted over the same guide wire. Contrast injection through the second catheter into the left coronary ostium resulted in immediate and fatal occlusion of the two major branches of the left coronary artery.

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REQUIREMENTS FOR THROMBORESISTANCE OF SURFACE‐HEPARINIZED MATERIALSa

Cited by 31 publications

References 16 publications

Interpositionskonnektoren mit Heparinbeschichtung für den Gefäßanschluß mikrochirurgischer Gewebelappen

Interpositionskonnektoren mit Heparinbeschichtung für den Gefäßanschluß mikrochirurgischer Gewebelappen

A Primate Model (Macaca Mulatta) to Study the Pharmacokinetics of Heparin and Its Fractions

Coronary Thromboembolism with Fatal Outcome Following Coronary Angiography

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