Requirements of Lgl in cell differentiation and motility during Drosophila ovarian follicular epithelium morphogenesis

Li, Qi; Feng, Shengjie; Yu, Ling-Zhu; Zhao, Gengchun; Li, Mingfa

doi:10.4161/fly.5.2.14436

Cited by 12 publications

(12 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3a). Lethal giant larva (LGL), Fasciclin 2 (FAS2), Neuroglian, Scribble and Discs large localize basolaterally 102–104 . Basolateral contacts are required to maintain the single-layer epithelium and must be remodelled to allow migration 103,105 .…”

Section: Stage Directionsmentioning

confidence: 99%

Group choreography: mechanisms orchestrating the collective movement of border cells

Montell

Yoon

Starz‐Gaiano

2012

Nat Rev Mol Cell Biol

217

247

View full text Add to dashboard Cite

Cell movements are essential for animal development and homeostasis but also contribute to disease. Moving cells typically extend protrusions towards a chemoattractant, adhere to the substrate, contract and detach at the rear. It is less clear how cells that migrate in interconnected groups in vivo coordinate their behaviour and navigate through natural environments. The border cells of the Drosophila melanogaster ovary have emerged as an excellent model for the study of collective cell movement, aided by innovative genetic, live imaging, and photomanipulation techniques. Here we provide an overview of the molecular choreography of border cells and its more general implications.

show abstract

Section: Stage Directionsmentioning

confidence: 99%

Group choreography: mechanisms orchestrating the collective movement of border cells

Montell

Yoon

Starz‐Gaiano

2012

Nat Rev Mol Cell Biol

217

247

View full text Add to dashboard Cite

show abstract

“…4.2d). All three members of the Scribble polarity module have been implicated in cell migration in a number of cell types including epithelial cells, endothelial cells, lymphocytes, astrocytes, and fibroblasts, both as single cells and in collective migration (Michaelis et al 2013;Vaira et al 2012;Li et al 2011a;Zhao et al 2008;Osmani et al 2006;Ludford-Menting et al 2005;Eastburn et al 2012;Bahri et al 2010), where they coordinate differential Rho-GTPases activity at the leading and trailing edge of the cell, polarization of the Golgi complex, capture of microtubule plus ends at the cell cortex, and E-cadherin activity (Osmani et al 2006;Etienne-Manneville et al 2005;Qin et al 2005;Manneville et al 2010;Lasserre et al 2010;Dahan et al 2012;Phua et al 2009). …”

Section: Directed Migrationmentioning

confidence: 99%

The Scribble–Dlg–Lgl Module in Cell Polarity Regulation

et al. 2015

View full text Add to dashboard Cite

“…Recent studies have shown that Lgl is required for the posterior translocation of oocyte-specific proteins [19] and in regulating differentiation and morphogenetic movement of the ovarian epithelial follicle cells in D. melanogaster [20]. Lgl is also required for the polarization of embryonic, imaginal disc, and follicular epithelia [4].…”

Section: Introductionmentioning

confidence: 99%

The lethal giant larvae Gene in Tribolium castaneum: Molecular Properties and Roles in Larval and Pupal Development as Revealed by RNA Interference

Xiao

Gao

et al. 2014

IJMS

View full text Add to dashboard Cite

We identified and characterized the TcLgl gene putatively encoding lethal giant larvae (Lgl) protein from the red flour beetle (Tribolium castaneum). Analyses of developmental stage and tissue-specific expression patterns revealed that TcLgl was constitutively expressed. To examine the role of TcLgl in insect development, RNA interference was performed in early (1-day) larvae, late (20-day) larvae, and early (1-day) pupae. The early larvae injected with double-stranded RNA of TcLgl (dsTcLgl) at 100, 200, and 400 ng/larva failed to pupate, and 100% mortality was achieved within 20 days after the injection or before the pupation. The late larvae injected with dsTcLgl at these doses reduced the pupation rates to only 50.3%, 36.0%, and 18.2%, respectively. The un-pupated larvae gradually died after one week, and visually unaffected pupae failed to emerge into adults and died during the pupal stage. Similarly, when early pupae were injected with dsTcLgl at these doses, the normal eclosion rates were reduced to only 22.5%, 18.0%, and 11.2%, respectively, on day 7 after the injection, and all the adults with abnormal eclosion died in two days after the eclosion. These results indicate that TcLgl plays an essential role in insect development, especially during their metamorphosis.

show abstract

Requirements of Lgl in cell differentiation and motility during Drosophila ovarian follicular epithelium morphogenesis

Cited by 12 publications

References 49 publications

Group choreography: mechanisms orchestrating the collective movement of border cells

Group choreography: mechanisms orchestrating the collective movement of border cells

The Scribble–Dlg–Lgl Module in Cell Polarity Regulation

The lethal giant larvae Gene in Tribolium castaneum: Molecular Properties and Roles in Larval and Pupal Development as Revealed by RNA Interference

Contact Info

Product

Resources

About