Rescue effect of sodium acetate in diabetes mellitus-associated testicular dysfunction is accompanied by PCSK9 modulation

Olaniyi, Kehinde S.; Badejogbin, Olabimpe C.; Saliu, Salam Babatunde; Olatunji, Lawrence Aderemi

doi:10.1016/j.biochi.2021.02.004

Cited by 9 publications

(2 citation statements)

References 42 publications

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“…Hypercholesterolemia, a medical disorder characterized by elevated levels of cholesterol in the bloodstream, has been found to potentially initiate an inflammatory response, resulting in an upregulation of pro-inflammatory cytokines such as TNF-α and IL-6. Consequently, this phenomenon can intensify the presence of testicular oxidative stress, thereby leading to potential tissue impairment [ 98 ].…”

Section: Discussionmentioning

confidence: 99%

Edible wild plants, chicory and purslane, alleviated diabetic testicular dysfunction, and insulin resistance via suppression 8OHdg and oxidative stress in rats

Saad,

Hassan,

Ghoneum

et al. 2024

PLoS ONE

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Testicular dysfunction is a prevalent health problem frequently reported in individuals with diabetes mellitus (DM). Oxidative-inflammatory reactions, hormonal and spermatic abnormalities often accompany this illness. Herbal remedies “particularly wild plants” including chicory (Chicorium Intybus) and purslane (Portulaca Oleracea) are emerging as popular agents for people dealing with these issues due to their ability to act as antioxidants, reduce inflammation, and exhibit antidiabetic effects. According to the collected data, the daily administration of chicory (Ch) seed-extract (250 mg/kg) or purslane (Pu) seed-extract (200 mg/kg) to streptozotocin (STZ)-induced diabetic rats (50 mg/kg) for 30 days resulted in the normalization of fasting blood glucose (FBG), serum fructosamine, insulin levels, and insulin resistance (HOMA-IR), as well as reducing lipid peroxidation end-product malondialdehyde (MDA) level, aldehyde oxidase (AO) and xanthene oxidase (XO) activities. While caused a considerable improvement in glutathione (GSH) content, superoxide dismutase (SOD), catalase (CAT) activity, and total antioxidant capacity (TAC) when compared to diabetic rats. Ch and Pu extracts had a substantial impact on testicular parameters including sperm characterization, testosterone level, vimentin expression along with improvements in body and testis weight. They also mitigated hyperlipidemia by reducing total lipids (TL), total cholesterol (TC) levels, and low-density lipoprotein cholesterol (LDL-C), while increasing high-density lipoprotein cholesterol (HDL-C). Furthermore, oral administration of either Ch or Pu notably attuned the elevated proinflammatory cytokines as tumor necrotic factor (TNF-α), C-reactive protein (CRP), and Interleukin-6 (IL-6) together with reducing apoptosis and DNA damage. This was achieved through the suppression of DNA-fragmentation marker 8OHdG, triggering of caspase-3 immuno-expression, and elevation of Bcl-2 protein. The histological studies provided evidence supporting the preventive effects of Ch and Pu against DM-induced testicular dysfunction. In conclusion, Ch and Pu seed-extracts mitigate testicular impairment during DM due to their antihyperglycemic, antilipidemic, antioxidant, anti-inflammatory, and antiapoptotic properties.

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Section: Discussionmentioning

confidence: 99%

Edible wild plants, chicory and purslane, alleviated diabetic testicular dysfunction, and insulin resistance via suppression 8OHdg and oxidative stress in rats

Saad,

Hassan,

Ghoneum

et al. 2024

PLoS ONE

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“…It is worth noting that acetate is related to diabetes-associated reproductive abnormalities. Acetate not only improved the hypothalamic-pituitary-ovarian function of female patients with T2DM by inhibiting histone deacetylase-5 (HDAC5) ( Olaniyi et al, 2021a ), but also alleviated the testicular dysfunction in male patients with diabetes by inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9) ( Olaniyi et al, 2021b ). Collectively, SCFAs, such as acetate, propionate and butyrate, have played an important role in the development of T2DM.…”

Section: Molecular Mechanisms Linking Host and The Gut Microbiota In ...mentioning

confidence: 99%

Gut Microbiota: An Important Player in Type 2 Diabetes Mellitus

Zhou

Sun

et al. 2022

Front. Cell. Infect. Microbiol.

130

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Type 2 diabetes mellitus (T2DM) is one of the common metabolic diseases in the world. Due to the rise in morbidity and mortality, it has become a global health problem. To date, T2DM still cannot be cured, and its intervention measures mainly focus on glucose control as well as the prevention and treatment of related complications. Interestingly, the gut microbiota plays an important role in the development of metabolic diseases, especially T2DM. In this review, we introduce the characteristics of the gut microbiota in T2DM population, T2DM animal models, and diabetic complications. In addition, we describe the molecular mechanisms linking host and the gut microbiota in T2DM, including the host molecules that induce gut microbiota dysbiosis, immune and inflammatory responses, and gut microbial metabolites involved in pathogenesis. These findings suggest that we can treat T2DM and its complications by remodeling the gut microbiota through interventions such as drugs, probiotics, prebiotics, fecal microbiota transplantation (FMT) and diets.

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Pathogenesis of testicular dysfunction in diabetes: exploring the mechanism and therapeutic interventions

Badejogbin,

Chijioke-Agu,

Olubiyi

et al. 2024

J Assist Reprod Genet

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Rescue effect of sodium acetate in diabetes mellitus-associated testicular dysfunction is accompanied by PCSK9 modulation

Cited by 9 publications

References 42 publications

Edible wild plants, chicory and purslane, alleviated diabetic testicular dysfunction, and insulin resistance via suppression 8OHdg and oxidative stress in rats

Edible wild plants, chicory and purslane, alleviated diabetic testicular dysfunction, and insulin resistance via suppression 8OHdg and oxidative stress in rats

Gut Microbiota: An Important Player in Type 2 Diabetes Mellitus

Pathogenesis of testicular dysfunction in diabetes: exploring the mechanism and therapeutic interventions

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