“…The most controversial issue is the onset time of rescuer fatigue, which inevitably results in marked deterioration of chest compression quality, especially of compression depth. Some studies reported a significant decrease in compression depth within 1 min from starting CPR [4,7,10], whereas other studies reported no marked decline in compression quality until 2 min [3,14]. Although the 2005 CPR guidelines considered the possibility of early rescuer fatigue, the 2005 CPR guidelines placed more emphasis on the possible benefit of minimal interruption and therefore recommended the RC2 method [8].…”