Research advance on the important role of selenoproteinin human health

Zhang, Di; He, Ning; Yang, Xiaoli; Zhang, Dandan; Li, Qiang; Xiong, Yongmin

doi:10.1360/tb-2021-1019

Cited by 3 publications

(2 citation statements)

References 56 publications

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“…In summary, this experiment adopted miniature Bama pigs as the research object, and they were treated with mixed feed for oral SeP administration.On the one hand, oral selenium supplements showed the metabolic process of different doses of organic Se in miniature Bama pigs.On the other hand, this study can provide some basis for reasonable Se supplementation by comparing the metabolic kinetics of different doses with inorganic Se metabolism, as well as the occurrence of peak concentration in plasma and peak time. SeP can be used as an important method of Se supplementation under reasonable control of Se dosage [18] .However, in this paper, the metabolic kinetics of organic Se were only preliminarily discussed at the animal level, while the metabolic kinetics of organic Se were not completely clear at the human level, and the metabolic kinetics of Se supplementation under pathological conditions remain to be further studied.…”

Section: Discussionmentioning

confidence: 98%

Oral Absorption, Distribution and Excretion of Selenium-Enriched Peptides from Cardamine violifolia in Miniature Bama pigs

et al. 2022

Preprint

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The aim of this study was to investigate the absorption, distribution, excretion of Selenium-enriched peptides(SeP) in miniature Bama pigs via oral route. Two different dosage groups of SeP was designed given 0.2 and 0.02 mg selenium per kilogram body weight respectively, and one control group was set given basic diet. A single administration of SeP was finished following with 2 weeks washout period and then a 7-day repeated administration of SeP was given. The concentrations of Se in plasma, tissues, urine and feces were measured by ICP-MS/MS, the activity of Glutathione peroxidase (GSH-PX) and content of selenium protein (SelP) in plasma were determined by ELISA Kit. Toxicokinetic parameters were calculated by fitting data with metabolic dynamics model using WinNonlin (6.3) software. Selenium from SeP was absorbed to plasma to maximum concentration with hours, mostly accumulated in the liver and kidney and mostly excreted by the gastrointestinal tract than by urine. Compared with control group, GSH-PX activity in SeP groups increased significantly after single or repeated administration, but no significant change were observed in SelP content, biochemical or hematological parameters.

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Section: Discussionmentioning

confidence: 98%

Oral Absorption, Distribution and Excretion of Selenium-Enriched Peptides from Cardamine violifolia in Miniature Bama pigs

et al. 2022

Preprint

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“…Selenium primarily serves a biological purpose in the human body in the form of selenoprotein. 11 According to earlier studies, selenoproteins can regulate biological processes such as cellular oxidative stress, endoplasmic reticulum stress, antioxidant defense, immune response, and inflammatory response, 12 anti-apoptosis, inhibition of transcription factor activity, promoting sperm maturation, participation in cellular redox capacity and thyroid hormone metabolism. 13 , 14 Higher eukaryotes have 2 different selenophosphate synthases, called SEPHS1 and SEPHS2 .…”

Section: Introductionmentioning

confidence: 99%

Pan-Cancer Study of the Prognosistic Value of Selenium Phosphate Synthase 1

Hao

Zhao

et al. 2023

Cancer Control

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Objective: This study sought to determine the mean prognostic usefulness of seleniumphosphate synthase ( SEPHS1) by investigating its expression in 33 human malignancies and its relationship to tumor immunity. Methods: The expression of selenophosphate synthase 1 ( SEPHS1) in 33 human malignant tumors was examined using the Genotype-Tissue Expression (GTEx), Cancer Genome Atlas (TCGA), and TIMER databases. Furthermore, the TCGA cohort was used to investigate relationships between SEPHS1 and immunological checkpoint genes (ICGs), tumor mutation burden (TMB), microsatellite instability (MSI), and DNA mismatch repair genes (MMRs). To establish independent risk factors and calculate survival probabilities for liver hepatocellular carcinoma (LIHC) and brain lower-grade glioma (LGG), Cox regression models and Kaplan-Meier curves were utilized. Eventually, the Genomics of Cancer Drug Sensitivity (GDSC) database was used to evaluate the drug sensitivity in LGG and LIHC patients with high SEPHS1 expression. Results: Overall, in numerous tumor tissues, SEPHS1 was highly expressed, and it significantly linked with the prognosis of LGG, ACC, and LIHC ( P < .05). Furthermore, in numerous cancers, SEPHS1 expression was linked to tumor-infiltrating immune cells (TIICs), TMB, MSI, and MMRs. According to univariate and multivariate Cox analyses, SEPHS1 expression was significant for patients with LGG and LIHC. Conclusion: High SEPHS1 expression has a better prognosis for LGG, while low SEPHS1 expression has a better prognosis for LIHC. Chemotherapy was advised for LGG patients, particularly for those with high SEPHS1 expression because it can predict how responsive patients will be to 5-Fluorouracil and Temozolomide. This interaction between SEPHS1 and chemoradiotherapy has a positive clinical impact and may be used as evidence for chemotherapy for LGG and LIHC patients.

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Research on Topic Mining and Evolution Trends of Functional Agriculture Based on the BERTopic Model

Lin,

Xin,

Peng

et al. 2024

Agriculture

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Based on the BERTopic model, this study analyzes 15,744 scientific papers in the field of functional agriculture from 1995 to 2024 to uncover core themes and evolutionary trends in global functional agriculture, and particularly focuses on revealing the developmental trajectory in China. The results indicate that global functional agriculture research is characterized by diverse themes and intensive study, forming a multi-topic cross-network centered on plant chemical extraction and agricultural soil research, with a focus on food nutrition, human health, and environmental protection. By contrast, China’s functional agriculture research demonstrates a more focused and in-depth approach, concentrating on functional food development and agricultural environmental protection themes, with notable growth trends in areas such as selenium-enriched products and resistant starch. Combined with China’s agricultural development environment, this study makes the following suggestions for the development of functional agriculture in China: (1) Promoting interdisciplinary cooperation between functional agriculture and other technologies. (2) Developing agricultural products with Chinese characteristics and forming Chinese functional agricultural product brands. (3) Utilizing smart farming technology to boost functional agriculture.

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Research advance on the important role of selenoproteinin human health

Cited by 3 publications

References 56 publications

Oral Absorption, Distribution and Excretion of Selenium-Enriched Peptides from Cardamine violifolia in Miniature Bama pigs

Oral Absorption, Distribution and Excretion of Selenium-Enriched Peptides from Cardamine violifolia in Miniature Bama pigs

Pan-Cancer Study of the Prognosistic Value of Selenium Phosphate Synthase 1

Research on Topic Mining and Evolution Trends of Functional Agriculture Based on the BERTopic Model

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