Research advances of secretory proteins in malignant tumors

Zhang, Na; Hao, Jia‐Jie; Cai, Yan; Wang, Ming-Rong

doi:10.21147/j.issn.1000-9604.2021.01.12

Cited by 7 publications

(6 citation statements)

References 160 publications

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“…In this study, we focused on testing the area within 10 mm of tumor tissue to make sure that the viscoelastic properties of the tumor tissue and not the healthy tissue were measured. The tumor itself, tumor microenvironment, and the other surrounding area are all affected by proinflammatory factors and molecules released from tumor cells ( Zhang et al, 2021 ). For example, tumor cells secrete diverse growth factors, proinflammatory cytokines, glycoproteins, enzymes, and exosomes.…”

Section: Discussionmentioning

confidence: 99%

Characterizing viscoelastic properties of human melanoma tissue using Prony series

Park

Chien

Brown

et al. 2023

Front. Bioeng. Biotechnol.

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Melanoma is the most invasive and deadly skin cancer, which causes most of the deaths from skin cancer. It has been demonstrated that the mechanical properties of tumor tissue are significantly altered. However, data about characterizing the mechanical properties of in vivo melanoma tissue are extremely scarce. In addition, the viscoelastic or viscous properties of melanoma tissue are rarely reported. In this study, we measured and quantitated the viscoelastic properties of human melanoma tissues based on the stress relaxation test, using the indentation-based mechanical analyzer that we developed previously. The melanoma tissues from eight patients of different ages (57–95), genders (male and female patients), races (White and Asian), and sites (nose, arm, shoulder, and chest) were excised and tested. The results showed that the elastic property (i.e., shear modulus) of melanoma tissue was elevated compared to normal tissue, while the viscous property (i.e., relaxation time) was reduced. Moreover, the tissue thickness had a significant impact on the viscoelastic properties, probably due to the amount of the adipose layer. Our findings provide new insights into the role of the viscous and elastic properties of melanoma cell mechanics, which may be implicated in the disease state and progression.

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Section: Discussionmentioning

confidence: 99%

Characterizing viscoelastic properties of human melanoma tissue using Prony series

Park

Chien

Brown

et al. 2023

Front. Bioeng. Biotechnol.

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“…Conversely, when the expression of GPX4 activity is promoted, cells can become tolerant to the occurrence of ferroptosis. It has been found [181,182] that RSL3, as an iron death inducer, can effectively act on GPX4 in cells and directly inhibit GPX4 activity, so as to reduce the antioxidant capacity of cells, allow a large amount of ROS to accumulate in cells, and ultimately lead to the occurrence of ferroptosis. In addition, certain compounds (such as ML162, withaferinA, DPI7, DPI10) and the chemotherapeutic agent (such as altretamine) can also directly or indirectly inhibit the expression of GPX4 activity in cells and ultimately induce ferroptosis in cells.…”

Section: Ferroptosis-related Signaling Pathway and Osmentioning

confidence: 99%

Effect of traditional Chinese medicine in osteosarcoma: Cross-interference of signaling pathways and potential therapeutic targets

Liu,

Jiang,

et al. 2024

Medicine

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Osteosarcoma (OS) has a high recurrence rate, disability rate, mortality and metastasis, it brings great economic burden and psychological pressure to patients, and then seriously affects the quality of life of patients. At present, the treatment methods of OS mainly include radiotherapy, chemotherapy, surgical therapy and neoadjuvant chemotherapy combined with limb salvage surgery. These treatment methods can relieve the clinical symptoms of patients to a certain extent, and also effectively reduce the disability rate, mortality and recurrence rate of OS patients. However, because metastasis of tumor cells leads to new complications, and OS cells become resistant with prolonged drug intervention, which reduces the sensitivity of OS cells to drugs, these treatments still have some limitations. More and more studies have shown that traditional Chinese medicine (TCM) has the characteristics of “multiple targets and multiple pathways,” and can play an important role in the development of OS through several key signaling pathways, including PI3K/AKT, Wnt/β-catenin, tyrosine kinase/transcription factor 3 (JAK/STAT3), Notch, transforming growth factor-β (TGF-β)/Smad, nuclear transcription factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), nuclear factor E2-related factor 2 (Nrf2), Hippo/YAP, OPG/RANK/RANKL, Hedgehog and so on. In this paper, the signaling pathways of cross-interference between active ingredients of TCM and OS were reviewed, and the development status of novel OS treatment was analyzed. The active ingredients in TCM can provide therapeutic benefits to patients by targeting the activity of signaling pathways. In addition, potential strategies for targeted therapy of OS by using ferroptosis were discussed. We hope to provide a unique insight for the in-depth research and clinical application of TCM in the fields of OS growth, metastasis and chemotherapy resistance by understanding the signaling crosstalk between active ingredients in TCM and OS.

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“…In detail, proteins secreted by cancer cells, including enzymes, cytokines, and growth factors, play roles in numerous biological and physiological functions, such as immune responses and intercellular communication [ 86 ]. A significant portion of the cancer secretome is detectable in the blood in measurable quantities, making these proteins accessible biomarkers compared to those located within tumor tissue [ 87 ].…”

Section: Circulating Biomarkers: Is There An Ideal One?mentioning

confidence: 99%

The Circulating Biomarkers League: Combining miRNAs with Cell-Free DNAs and Proteins

Felekkis,

Papaneophytou

2024

IJMS

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The potential of liquid biopsy for the prognosis and diagnosis of diseases is unquestionable. Within the evolving landscape of disease diagnostics and personalized medicine, circulating microRNAs (c-miRNAs) stand out among the biomarkers found in blood circulation and other biological fluids due to their stability, specificity, and non-invasive detection in biofluids. However, the complexity of human diseases and the limitations inherent in single-marker diagnostics highlight the need for a more integrative approach. It has been recently suggested that a multi-analyte approach offers advantages over the single-analyte approach in the prognosis and diagnosis of diseases. In this review, we explore the potential of combining three well-studied classes of biomarkers found in blood circulation and other biofluids—miRNAs, DNAs, and proteins—to enhance the accuracy and efficacy of disease detection and monitoring. Initially, we provide an overview of each biomarker class and discuss their main advantages and disadvantages highlighting the superiority of c-miRNAs over the other classes of biomarkers. Additionally, we discuss the challenges and future directions in integrating these biomarkers into clinical practice, emphasizing the need for standardized protocols and further validation studies. This integrated approach has the potential to revolutionize precision medicine by offering insights into disease mechanisms, facilitating early detection, and guiding personalized therapeutic strategies. The collaborative power of c-miRNAs with other biomarkers represents a promising frontier in the comprehensive understanding and management of complex diseases. Nevertheless, several challenges must be addressed before this approach can be translated into clinical practice.

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Research advances of secretory proteins in malignant tumors

Cited by 7 publications

References 160 publications

Characterizing viscoelastic properties of human melanoma tissue using Prony series

Characterizing viscoelastic properties of human melanoma tissue using Prony series

Effect of traditional Chinese medicine in osteosarcoma: Cross-interference of signaling pathways and potential therapeutic targets

The Circulating Biomarkers League: Combining miRNAs with Cell-Free DNAs and Proteins

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