Research and Application of Glycoprotein Sensors Based on Glycosyl Recognition

Liang, Junyu; Tong, Peihong; Li, Jianping

doi:10.1016/s1872-2040(19)61185-0

Cited by 5 publications

(1 citation statement)

References 82 publications

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“…Glycoproteins are ubiquitous in organisms and can be used as carriers of cellular information function. They can not only used as markers for disease diagnosis, but also for monitoring and interventional therapy in the future 1 . Immunoglobulin G (IgG) is an important component of human serum immunoglobulin and an important indicator of human immune function.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a Sandwich-like Complex “MIPs-Target Molecule-Magnetic SERS Probe” and SERS Determination of Immunoglobulin G

2020

ANAL. SCI.

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Based on the reversible covalent binding between borates and glycoproteins, we proposed a scheme that can specifically recognized and detected immunoglobulin G (IgG). The application of magnetic materials to enrich SERS probes can provided the enhanced signal and the repeatability. The results showed that the prepared sandwich-like complex showed high sensitivity and excellent selectivity for IgG. The Raman peak intensity showed a good linear relationship in the concentration range of 1mg/mL~1ng/mL. The linear equation was y=657.93x+2963.9, R 2 =0.996. Parallel testing of this sandwich-like complex proved to have excellent repeatability. This method provided a new possibility for clinical non-immunity and quantitative detection of IgG.

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Section: Introductionmentioning

confidence: 99%