Strip filling mining in a goaf is of great significance for solving the ‘three under’ coal-pressure and mining-area ecological environment problems in Central and Eastern China, but the disturbance characteristics of filling parameters on overlying rock are not clear at present. Taking the geological conditions of the CT30101 working face in Mahuangliang coal mine and the short-wall interval strip filling as a background, the strength parameters (cohesion and friction angle), deformation parameters (elastic modulus and Poisson’s ratio), and structural parameters (strip width and spacing) of the filling body were selected as experimental factors, and the maximum settlement of the direct roof and the ground surface was taken as the evaluation index. The influence degree of each factor was quantitatively characterized via a variance analysis and an F test, and the main control factors of the strip filling overburden settlement were proposed. The roof and surface displacement, the stress evolution law of the filling body, and the shape change of the surrounding rock plastic zone under different levels of main control factors in the entire process of mining filling coupling were analyzed in detail. The results showed that the cohesion of the backfill had a highly significant impact on the direct roof settlement, the strip spacing and the friction angle of backfill had a significant impact on it, the cohesion of the backfill and the strip spacing had a certain impact on the surface settlement, and the two had a cross-coupling effect. In the process of mining and filling, the stress evolution of the filling body was extremely complex, and it finally presented a saddle shape that was high on both sides and low in the middle; the majority of the strata and the filling body primarily exhibited shear damage, with a small amount of tensile failure zones appearing only in the direct roof and mid-section of the filling body. The above conclusions have a certain guiding significance for the optimal design of strip filling in a goaf.