Research and Application of Targeting Nano-Drugs

Liu, Changxiao

doi:10.5101/nbe.v3i2.p73-83

Cited by 5 publications

(5 citation statements)

References 50 publications

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“…Particles between 10–70 nm have been shown to penetrate capillary vessels. 21 Thus, synthesized MNPs found to be compatible to enhance drug delivery across the tightly junctioned BMECs along the capillaries lining throughout the cerebral microvasculature. Furthermore, in view of the fact that particles between 70–200 nm possess longer blood circulation time, MNPs of 25–40 nm size could be successfully hybridized with liposomes for synthesis of magnetoliposomes of about 100 nm which will enhance the bioavailability of associated drugs.…”

Section: Resultsmentioning

confidence: 98%

Therapeutical Neurotargeting via Magnetic Nanocarrier: Implications to Opiate-Induced Neuropathogenesis and NeuroAIDS

Sagar¹,

Pilakka-Kanthikeel²,

Atluri³

et al. 2015

j biomed nanotechnol

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Magnetite (Fe3O4) is the most commonly and extensively explored magnetic nanoparticles (MNPs) for drug-targeting and imaging in the field of biomedicine. Nevertheless, its potential application as safe and effective drug-carrier for CNS (Central Nervous System) anomalies is very limited. Previous studies have shown an entangled epidemic of opioid use and HIV infection and increased neuropathogenesis. Opiate such as morphine, heroine, etc. are used frequently as recreational drugs. Existing treatments to alleviate the action of opioid are less effective at CNS level due to impermeability of therapeutic molecules across brain barriers. Thus, development of an advanced nanomedicine based approach may pave the way for better treatment strategies. We herein report magnetic nanoformulation of a highly selective and potent morphine antagonist, CTOP (D-Pen-Cys-Tyr-DTrp-Orn-Thr-Pen-Thr-NH2), which is impenetrable to the brain. MNPs, synthesized in size range from 25 to 40 nm, were characterized by Transmission electron microscopy and assembly of MNPs-CTOP nanoformulations were confirmed by FTIR spectroscopy and fluorescent detection. Flow-cytometry analysis showed that biological efficacy of this nanoformulation in prevention of morphine induced apoptosis in peripheral blood mononuclear cells remains equivalent to that of free CTOP. Similarly, confocal microscopy reveals comparable efficacy of free and MNPs bound CTOP in protecting modulation of neuronal dendrite and spine morphology during morphine exposure and morphine-treated HIV infection. Further, typical transmigration assay showed increased translocation of MNPs across in vitro blood-brain barrier upon exposure of external magnetic force where barrier integrity remains unaltered. Thus, the developed nanoformulation could be effective in targeting brain by application of external magnetic force to treat morphine addiction in HIV patients.

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Section: Resultsmentioning

confidence: 98%

Therapeutical Neurotargeting via Magnetic Nanocarrier: Implications to Opiate-Induced Neuropathogenesis and NeuroAIDS

Sagar¹,

Pilakka-Kanthikeel²,

Atluri³

et al. 2015

j biomed nanotechnol

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“…For drug administration, the microneedle approach has the advantages of avoiding the effect of the gastrointestinal digestion, accelerating the drug absorption, prolonging the effective time, and patient self-administered without needing doctors (Prausnitz and Langer 2008 ). For biosensing, the microneedle approach provides possible continuous monitoring of the biomarkers in interstitial fluid (Liu et al 2004 ).…”

Section: Introductionmentioning

confidence: 99%

Microneedles: materials, fabrication, and biomedical applications

Luo

Yang

Cui

2023

Biomed Microdevices

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The microneedles have attracted great interests for a wide range of transdermal biomedical applications, such as biosensing and drug delivery, due to the advantages of being painless, semi-invasive, and sustainable. The ongoing challenges are the materials and fabrication methods of the microneedles in order to obtain a specific shape, configuration and function of the microneedles to achieve a target biomedical application. Here, this review would introduce the types of materials of the microneedles firstly. The hardness, Young's modulus, geometric structure, processability, biocompatibility and degradability of the microneedles are explored as well. Then, the fabrication methods for the solid and hollow microneedles in recent years are reviewed in detail, and the advantages and disadvantages of each process are analyzed and compared. Finally, the biomedical applications of the microneedles are reviewed, including biosensing, drug delivery, body fluid extraction, and nerve stimulation. It is expected that this work provides the fundamental knowledge for developing new microneedle devices, as well as the applications in a variety of biomedical fields.

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“…[3][4][5][6] However, the clinical applications of celastrol have been hindered by its low solubility. Several methods have been developed to increase the water-solubility of poorly soluble drugs, [7][8][9][10][11][12] but with limited successes.…”

Section: Introductionmentioning

confidence: 99%

Optimized Preparation of Celastrol-Loaded Polymeric Nanomicelles Using Rotatable Central Composite Design and Response Surface Methodology

Xia

Wang²,

Shi³

et al. 2012

j biomed nanotechnol

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Celastrol has been found to be a potent anti-inflammatory and antitumor plant derivative recently. Herein we established an accurate reverse phase HPLC (RP-HPLC) determination method of celastrol, and prepared an effective nanoscale drug delivery system from the optimized formulations of celastrol-loaded carboxyl functioned poly(ethylene glycol)-block-poly(propylene glycol)-blockpoly(ethylene glycol)(PEO-block-PPO-block-PEO, Pluronic) polymeric nanomicelles. Rotatable central composite design (RCCD) and response surface methodology (RSM) were applied to improve the celastrol entrapment efficiency (EE), drug loading percentage (DLP), and decrease the particle size. The characteristics of the optimized micelles including particle size distribution, morphology, zeta potential and in vitro release of celastrol from micelles were carried out. Results showed that RP-HPLC method was successfully applied to detect and qualify the celastrol. The drug quantification range of the method was 20-200 g/mL with a linear correlation coefficient of greater than 0.999. The average accuracy (99.763%), the precision (0.521%) and recovery (99.63%) for this method were good. The optimal conditions for the preparation of celastrol-loaded polymeric nanomicelles were found to be: the celastrol/polymer weight ratio 8.5-9 mg/25 mg, hydration volume 11-17 mL. Under the optimal conditions, the EE was 100 3 ± 4 3%, DLP was 22 8 ± 1 0%, the average particle size was 117 3 ± 1 27 nm and the zeta potential was −2 19 ± 0 15 mV. Transmission electron micrograph (TEM) showed the micelles to be oval and rodlike shaped, with mean diameter around 20 nm. The in vitro experiments proved that celastrol in polymeric nanomicelles released gradually over the period of 24 h. These results showed that the RCCD and RSM could efficiently be applied for optimized preparation of celastrol-loaded polymeric nanomicelles.

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Research and Application of Targeting Nano-Drugs

Cited by 5 publications

References 50 publications

Therapeutical Neurotargeting via Magnetic Nanocarrier: Implications to Opiate-Induced Neuropathogenesis and NeuroAIDS

Therapeutical Neurotargeting via Magnetic Nanocarrier: Implications to Opiate-Induced Neuropathogenesis and NeuroAIDS

Microneedles: materials, fabrication, and biomedical applications

Optimized Preparation of Celastrol-Loaded Polymeric Nanomicelles Using Rotatable Central Composite Design and Response Surface Methodology

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