Research and development of drug delivery systems based on drug transporter and nano-formulation

Peng, Yi; Chen, Lu; Ye, Sheng; Kang, Yu; Liu, Junqing; Zeng, Su; Yu, Lushan

doi:10.1016/j.ajps.2020.02.004

Cited by 80 publications

(37 citation statements)

References 141 publications

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“…These particles can be employed for MRI cell tracking and multiple treatment strategies, including magnetic fluid hyperthermia against glioma. The larger size of the magnetic particles used here, for example, enables the more effective use of external magnetic fields for magnetic drug targeting 54 – 56 .…”

Section: Discussionmentioning

confidence: 99%

Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment

Dallet

Stanicki

Voisin

et al. 2021

Sci Rep

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Iron oxide particles (IOP) are commonly used for Cellular Magnetic Resonance Imaging (MRI) and in combination with several treatments, like Magnetic Fluid Hyperthermia (MFH), due to the rise in temperature they provoke under an Alternating Magnetic Field (AMF). Micrometric IOP have a high sensitivity of detection. Nevertheless, little is known about their internalization processes or their potential heat power. Two micrometric commercial IOP (from Bangs Laboratories and Chemicell) were characterized by Transmission Electron Microscopy (TEM) and their endocytic pathways into glioma cells were analyzed. Their Specific Absorption Rate (SAR) and cytotoxicity were evaluated using a commercial AMF inductor. T2-weighted imaging was used to monitor tumor growth in vivo after MFH treatment in mice. The two micron-sized IOP had similar structures and r2 relaxivities (100 mM−1 s−1) but involved different endocytic pathways. Only ScreenMAG particles generated a significant rise in temperature following AMF (SAR = 113 W g−1 Fe). After 1 h of AMF exposure, 60% of ScreenMAG-labeled cells died. Translated to a glioma model, 89% of mice responded to the treatment with smaller tumor volume 42 days post-implantation. Micrometric particles were investigated from their characterization to their intracellular internalization pathways and applied in one in vivo cancer treatment, i.e. MFH.

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Section: Discussionmentioning

confidence: 99%

Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment

Dallet

Stanicki

Voisin

et al. 2021

Sci Rep

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“…A number of different types of nanocarriers such as liposomes, dendrimers, polymeric nanoparticles (micelles, spheres, capsules), polymeric complex nanoparticles, cyclodextrins, nano-caseins, nanocrystals, electrospun nano-fibers, electro-sprayed nano-particles, nano-spray dried particles, covalent organic frameworks, hydrogels, inorganic nanoparticles (silica, iron, gold, titanium, carbon based nanoparticles) as well as hybrid nanoparticles (organic-inorganic based structures) have been developed. The research is focused on their in vivo absorption, permeation, and release together with toxicity, residual solvents, and biological fate during digestion, absorption, and excretion [ 59 , 60 , 82 , 83 , 89 , 90 , 91 , 92 ].…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Chronic Inflammatory Diseases, Anti-Inflammatory Agents and Their Delivery Nanosystems

Plachá

Jampílek

2021

Pharmaceutics

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Inflammatory diseases, whether caused by excessive stress on certain tissues/parts of the body or arising from infections accompanying autoimmune or secondary diseases, have become a problem, especially in the Western world today. Whether these are inflammations of visceral organs, joints, bones, or the like, they are always a physiological reaction of the body, which always tries to eradicate noxious agents and restore tissue homeostasis. Unfortunately, this often results in damage, often irreversible, to the affected tissues. Nevertheless, these inflammatory reactions of the body are the results of excessive stress, strain, and the generally unhealthy environment, in which the people of Western civilization live. The pathophysiology and pathobiochemistry of inflammatory/autoimmune processes are being studied in deep detail, and pharmaceutical companies are constantly developing new drugs that modulate/suppress inflammatory responses and endogenous pro-inflammatory agents. In addition to new specifically targeted drugs for a variety of pro-inflammatory agents, a strategy can be found for the use of older drugs, which are formulated into special nanodrug delivery systems with targeted distribution and often modified release. This contribution summarizes the current state of research and development of nanoformulated anti-inflammatory agents from both conventional drug classes and experimental drugs or dietary supplements used to alleviate inflammatory reactions.

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“…Targeted liposomes with proteins on their surface (d) Lombardo et al 2019;Weiss et al 2020). Nanotechnology could provide safety and effectiveness for the treatment of COVID-19, enabling the encapsulation of drugs, their targeting at specific sites, and the reduction of drug toxicity (Lombardo et al 2019;Weiss et al 2020;Peng et al 2020).…”

Section: Nanotechnology For the Prevention And Treatment Of Covid-19mentioning

confidence: 99%

“…According to the literature, nanotechnology provides advantages from the use of nanosystems, such as liposomes, polymeric and lipid nanoparticles, metallic nanoparticles, and micelles, for the encapsulation of drugs, promoting the improvement of pharmacological drug properties (Youssef et al 2019 ; Lombardo et al 2019 ; Weiss et al 2020 ). Nanotechnology could provide safety and effectiveness for the treatment of COVID-19, enabling the encapsulation of drugs, their targeting at specific sites, and the reduction of drug toxicity (Lombardo et al 2019 ; Weiss et al 2020 ; Peng et al 2020 ).…”

Section: Nanotechnology For the Prevention And Treatment Of Covid-19mentioning

confidence: 99%

Pharmaceutical nanotechnology: which products are been designed against COVID-19?

Cavalcanti

Nogueira

2020

J Nanopart Res

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The current pandemic COVID-19, caused by the SARS-CoV-2 virus, has been affecting thousands of people worldwide, promoting high numbers of deaths. With this, the world population is going through a process of changing habits, with social distance, improvement of hygiene techniques, to reduce the spread of the SARS-CoV-2 virus and, consequently, reduce the number of hospitalized people in serious condition, as well as the mortality rate. This scenario has been promoting a continuous search for researchers, in the most varied areas, for possible methods of prevention or cure. Specifically, in the field of pharmaceutical nanotechnology, a variety of products are being developed against SARS-CoV-2. Under these circumstances, we propose here an exposition of some of the nanotechnological products (nanoscale between 1 to 1000 nm) currently designed for the detection of the virus, for the prevention and treatment of COVID-19, in addition to equipment for personal protection. We believe that pharmaceutical nanotechnology will be a valuable tool in the disease from the development of products that guarantee our protection against the SARS-CoV-2 virus.

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Research and development of drug delivery systems based on drug transporter and nano-formulation

Cited by 80 publications

References 141 publications

Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment

Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment

Chronic Inflammatory Diseases, Anti-Inflammatory Agents and Their Delivery Nanosystems

Pharmaceutical nanotechnology: which products are been designed against COVID-19?

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