The influence of pulverized coal particle size on combustion and NOx formation of 660MW tangential combustion ultra-supercritical boiler in a power plant was studied by using commercial software FLUENT. The average particle size of pulverized coal was set at 61μm, 71μm and 80μm, respectively. The results show that with the decrease of pulverized coal particle size, the overall temperature level of the boiler increases, the average temperature of the main combustion zone increases, the temperature of the upper part of the main combustion zone decreases, and the combustion of pulverized coal is more incomplete. However, the probability of particles sticking to the wall and the probability of coking and slagging of the boiler increases. The amount of NOx produced in the main combustion zone decreases, while the amount of NOx produced in the upper part of the main combustion zone increases, while the overall amount of NOx produced increases slightly.