Research and development of the inspiration timing evaluation system in the pressurized metered dose inhaler(pMDI)

Watanabe, T.; Hattori, Takumu; Maeda, Kouji; Tukamoto, Sousuke; Tobata, Hiroshi

doi:10.4286/jjmi.84.543

Cited by 3 publications

(2 citation statements)

References 1 publication

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“…In the present case, the patient took inhaled ciclesonide and her symptoms improved, although we cannot exclude the possibility that this would have been the natural course of the disease in this patient. In cases when it is difficult to synchronize drug spraying and inspiration as ciclesonide is administered using a pressurized metered-dose inhaler, the rate of drug arrival into the lungs may be reduced and may result in inadequate therapeutic efficacy [13]; however, in this case, the patient was able to inhale ciclesonide with guidance from nurses and without the use of an inhalationassistive device.…”

Section: Discussionmentioning

confidence: 99%

Prolonged presence of SARS-CoV-2 in a COVID-19 case with rheumatoid arthritis taking iguratimod treated with ciclesonide

Baba

Kanamori

Oshima

et al. 2020

Journal of Infection and Chemotherapy

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We report a coronavirus disease 2019 (COVID-19) case with rheumatoid arthritis taking iguratimod. The patient who continued iguratimod therapy without dose reduction was treated with ciclesonide had an uneventful clinical course, but prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was observed after resolution of symptoms. The effects of disease-modifying antirheumatic drugs (DMARDs) and ciclesonide on clinical course and viral shedding remain unknown and warrant further investigation.

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Section: Discussionmentioning

confidence: 99%

Prolonged presence of SARS-CoV-2 in a COVID-19 case with rheumatoid arthritis taking iguratimod treated with ciclesonide

Baba

Kanamori

Oshima

et al. 2020

Journal of Infection and Chemotherapy

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“…Although utilizing smaller and less intrusive sensors, this approach was too easily affected by external sounds, which are pervasive in normal user environments. Hence, a thermistor-based method was proposed that senses changes in temperature inside the pMDI canister 13 . However, this method is similarly affected by external influences, and its application to dry powder inhalers is not feasible.…”

Section: Introductionmentioning

confidence: 99%

Inhalation motion analysis and visualization of error areas using two IMU sensors

Hasegawa,

Shimono,

Masaki

et al. 2024

Preprint

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This paper proposes an inhaler-use behavior evaluation method that uses inertial sensors to monitor patients with bronchial asthma and chronic obstructive pulmonary disease (COPD). COPD is common disease, and the accurate use of inhalers is vital to controlling its symptoms. However, many patients improperly use their inhalers. Hence, by augmenting an Ellipta™ inhaler with inertial measurement units, this study evaluates patient inhalation motions using the acquired motion data. Compared with conventional methods, ours is less affected by external factors, such as sound and temperature, and it can be applied outside clinical settings. Specifically, a linear discriminant analysis algorithm is provided for selecting characteristic variables for each error type, and a judgment method using these variables is proposed. A dynamic programming matching algorithm is then applied to determine correctness. Experimental results show that our method provides high discriminant accuracy, and it accounts for the similarity of waveforms, which allows us to visualize errors, unlike contemporary methods. We expect that our inhalation method and the accompanying dataset will offer valuable guidance for future research as well as useful feedback to patients.

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Inhaler Motion Evaluation Via Weighted DP Matching

Hasegawa

Shimono

Takano³

et al. 2023

IEEJ Journal IA

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Non-memberPatients diagnosed with bronchial asthma or chronic obstructive pulmonary disease (COPD) are required to use inhalers to control their symptoms. However, approximately 70 % of the patients use their inhalers incorrectly because of misunderstandings regarding their use or habituation owing to long-term use. Currently, in-person instructions provided by pharmacists or doctors are the only remedy to this problem. Therefore, new evaluation method, which eliminates the input of a doctor or pharmacist, is urgently needed. This study aims to realize automatic evaluation of individual inhaler motion. A new sensing attachment with inertial measurement unit (IMU) is developed for an inhaler device. We propose an evaluation method using data from the sensing attachment, without doctor or pharmacist issued instructions. The proposed evaluation method for inhaler motion is based on a dynamic programming (DP) matching algorithm. Furthermore, the evaluation method is verified via suitable clinical experiments. Based on the experimental results, all clinical data could be classified by the proposed method.

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Research and development of the inspiration timing evaluation system in the pressurized metered dose inhaler(pMDI)

Cited by 3 publications

References 1 publication

Prolonged presence of SARS-CoV-2 in a COVID-19 case with rheumatoid arthritis taking iguratimod treated with ciclesonide

Prolonged presence of SARS-CoV-2 in a COVID-19 case with rheumatoid arthritis taking iguratimod treated with ciclesonide

Inhalation motion analysis and visualization of error areas using two IMU sensors

Inhaler Motion Evaluation Via Weighted DP Matching

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