Research and implementation of adverse reaction automatic warning algorithm on Chinese medicine injection

Zhuang, Yan; Xie, Bangtie; Xie, Yan-Ming; Weng, Shengxin

doi:10.4268/cjcmm20121805

Cited by 2 publications

(1 citation statement)

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“…But its displacement is less; its maximum displacement only is 45µm. In order to increase the actuator's displacement under the condition of insuring the higher resolution, this paper provides a displacement amplifying mechanism to amplify the piezoelectric stack's displacement, which is based on the orthogonal triangle enlarge principle [3,4,5]. After the static test of this device, it is found that the piezoelectric stack's displacement using the amplifying mechanism is 3.3 multiple than the original.…”

Section: Piezoelectric Actuator and Its Peculiaritiesmentioning

confidence: 99%

Dynamic Peculiarity of Piezoelectric-Stack Displacement-Amplifying Actuator

Hong

Jin²,

Hu³

et al. 2011

AMM

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In order to find out the dynamic peculiarity of piezoelectric-stack displacement-amplifying actuator, three methods: harmonic response analysis, impedance test and dynamic grating projection are used to analyze it. Experimental results indicate that the displacement-amplifying mechanism can provide large output torque; its response time is less than 0.3ms; its mutation time of displacement is less than 0.5ms, the fluctuation of displacement is less than 5um, and the change of displacement vs. voltage is linearity variety; its dynamic displacement is smooth, when discharging. After analyzing the actuator, some virtues of dynamic response peculiarity are shown: rapidly responding, tiny displacement fluctuates, fine displacement linearity, higher precision, large output torque, etc. Therefore it can be abroad applied in many micro-displacement control and drive systems, which need high precision and large displacement. Its application prospect is worth to expect.

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Section: Piezoelectric Actuator and Its Peculiaritiesmentioning

confidence: 99%

Dynamic Peculiarity of Piezoelectric-Stack Displacement-Amplifying Actuator

Hong

Jin²,

Hu³

et al. 2011

AMM

View full text Add to dashboard Cite

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Reevaluation of the post-marketing safety of Shuxuening injection based on real-world and evidence-based evaluations

Wang

Shi²,

Ding³

et al. 2018

DDDT

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AimTo evaluate the factors influencing suspected hypersensitivity and adverse systemic reactions after Shuxuening injection and to provide innovative ideas and methods for the reevaluation of post-marketing safety of Shuxuening.MethodsThis study used a prospective, nested case–control study design, combined with a prescription sequence analysis design method. It classified patients who exhibited trigger signals after administration of Shuxuening injection as suspected allergic patients and made comparisons with patients who did not report adverse effects to calculate the correlation between relevant risk factors and suspected allergic reactions. Randomized controlled studies and cohort studies of the adverse drug reaction (ADR) of Shuxuening were performed using a computer database. Data retrieval was carried out by the foundation governing the individual database. Meta-analysis was performed by using R3.2.3 software to evaluate the ADRs of Shuxuening.ResultsThe results of real-world study showed that administration of Shuxuening in combination with potassium aspartate and magnesium, atorvastatin calcium, Shengmai injection, pantoprazole sodium, or high-dose medication was a risk factor for suspected allergic reactions. Meta-analysis showed that the incidence of adverse events was 5.84% (95% CI 0.0499; 0.0674), and serious adverse reaction rate was 4.36% (95% CI 0.0188; 0.0760) when Shuxuening was used in combination with these drugs. The incidence of allergic reaction was also influenced by the vehicle, duration of treatment, single dose, and indicated vs off-label use.ConclusionRisk factors for adverse reaction following the use of Shuxuening injection in patients are associated with a single dose, vehicle, type of disease, and combination with potassium aspartate, atorvastatin calcium, Shengmai injection, injection with pantoprazole sodium, and other drugs. Physicians should be careful to follow guidelines when administering this drug. We further propose that the unique methodology used in this study may be useful for reevaluation of the safety of other traditional Chinese medicines.

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Research and implementation of adverse reaction automatic warning algorithm on Chinese medicine injection

Cited by 2 publications

References 0 publications

Dynamic Peculiarity of Piezoelectric-Stack Displacement-Amplifying Actuator

Dynamic Peculiarity of Piezoelectric-Stack Displacement-Amplifying Actuator

Reevaluation of the post-marketing safety of Shuxuening injection based on real-world and evidence-based evaluations

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