In 2019, the State Council issued the "National Vocational Education Reform Plan" and the Ministry of Education issued the "Opinions on Implementing High-level Vocational Schools and Professional Construction Plans with Chinese Characteristics" documents, requiring concentrated efforts to build a group of high-level professional groups. Taking the actual situation of the construction of high-level professional groups as the research object, this paper connects the occupational post groups and serving regional industries of regional industrial clusters, analyzes the construction background, group logic, talent training mode and other construction projects of professional groups, and builds a guarantee mechanism for the sustainable development of professional groups.