2017
DOI: 10.4238/gmr16039829
|View full text |Cite
|
Sign up to set email alerts
|

Research Article Alcohol metabolizing gene polymorphisms and their relationship with oral cancer risk and clinicopathological features

Abstract: Oral cancer incidence is higher in individuals between the fifth and seventh decades of life, but some studies indicate a decreasing age trend. From the epidemiological point of view, alcohol consumption is associated with the emergence of oral cancer by interfering with mechanisms of DNA synthesis and repair. From a genetic standpoint, variant alleles in genes encoding the enzymes of alcohol (CYP2E1 and ADH) and acetaldehyde (ALDH2) metabolism may play an important role in the genesis of oral cancer. This stu… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2019
2019
2024
2024

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(1 citation statement)
references
References 24 publications
0
1
0
Order By: Relevance
“…CYP2E1 also can induce ROS formation that can damaging DNA, leading to mutation and increased cell growth [38], [39]. Polymorphism of CYP2E1 had known to be associated with cancers including NPC [40], [41], [42], [43]. The polymorphism increases the transcription and activity of CYP2E1.…”
Section: Discussionmentioning
confidence: 99%
“…CYP2E1 also can induce ROS formation that can damaging DNA, leading to mutation and increased cell growth [38], [39]. Polymorphism of CYP2E1 had known to be associated with cancers including NPC [40], [41], [42], [43]. The polymorphism increases the transcription and activity of CYP2E1.…”
Section: Discussionmentioning
confidence: 99%