Research Article: The influence of acetylcholinesterase on anxiety- and depression-like behaviors in fluoxetine-treated male mice

McCloskey, Molly C.; Young, Tyler; Anderson, Spencer

doi:10.1893/bios-d-15-00013.1

Cited by 12 publications

(6 citation statements)

References 25 publications

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“…However, several studies have found contradicting results on the effects of AChE inhibition on murine models of depression. Behavioral studies have discovered that enhancing ACh neurotransmission in the hippocampus via AChE inhibition is enough to evoke anxiety- and depression-like symptoms in rodents, which were later alleviated through fluoxetine administration [ 56 , 57 , 58 ]. Similar findings have also been reported for adolescents who have been exposed to substantial amounts of cholinesterase inhibitors in agricultural pesticides [ 59 ].…”

Section: Resultsmentioning

confidence: 99%

Clitorienolactones and Isoflavonoids of Clitorea ternatea Roots Alleviate Stress-Like Symptoms in a Reserpine-Induced Zebrafish Model

et al. 2021

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Clitorea ternatea has been used in Ayurvedic medicine as a brain stimulant to treat mental illnesses and mental functional disorders. In this study, the metabolite profiles of crude C. ternatea root extract (CTRE), ethyl acetate (EA), and 50% aqueous methanol (50% MeOH) fractions were investigated using ultrahigh-performance liquid chromatography–diode array detector–tandem mass spectrometry (UHPLC–DAD–MS/MS), while their effect on the stress-like behavior of zebrafish, pharmacologically induced with reserpine, was investigated. A total of 32 compounds were putatively identified, among which, a series of norneolignans, clitorienolactones, and various flavonoids (flavone, flavonol, isoflavone, and isoflavanone) was found to comprise the major constituents, particularly in the EA and 50% MeOH fractions. The clitorienolactones, presently unique to the species, were present in both the free and glycosylated forms in the roots. Both the EA and 50% MeOH fractions displayed moderate effects on the stress-induced zebrafish model, significantly decreasing freezing duration and elevating the total distance travelled and average velocity, 72 h post-treatment. The results of the present study provide further evidence that the basis for the use of C. ternatea roots in traditional medicine to alleviate brain-related conditions, such as stress and depression, is attributable to the presence of clitorienolactones and the isoflavonoidal constituents.

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Section: Resultsmentioning

confidence: 99%

Clitorienolactones and Isoflavonoids of Clitorea ternatea Roots Alleviate Stress-Like Symptoms in a Reserpine-Induced Zebrafish Model

et al. 2021

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“…However, it was reported that the cholinergic anti-inflammatory pathway is up-regulated in MDD. Fluoxetine (an SSRI inhibitor) was administered to mice and it was demonstrated to affect cholinergic tone by altering serotonin levels and consequently increasing AChE activity [206]. Furthermore, an increase in AChE activity correlated with a decrease in anxiety behaviors in mice in OFT.…”

Section: Depressive Disordersmentioning

confidence: 99%

Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis

Walczak-Nowicka

Herbet

2021

IJMS

118

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Acetylcholinesterase (AChE) plays an important role in the pathogenesis of neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative stress and aggregation of pathological proteins. There is a search for new compounds that can prevent the occurrence of neurodegenerative diseases and slow down their course. The aim of this review is to present the role of AChE in the pathomechanism of neurodegenerative diseases. In addition, this review aims to reveal the benefits of using AChE inhibitors to treat these diseases. The selected new AChE inhibitors were also assessed in terms of their potential use in the described disease entities. Designing and searching for new drugs targeting AChE may in the future allow the discovery of therapies that will be effective in the treatment of neurodegenerative diseases.

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“…Since the neurobiology and etiology of treatment options of depression in PD are not fully understood, we tested here the effect of the injection of 1 ng BoNT-A into the DA-depleted CPu of hemi-PD rats on depression-like and anxiety-like behaviors. It is known that the cholinergic system, including the striatum, plays a central role not only in cognition but also in depression [ 121 , 122 , 123 , 124 , 125 , 126 , 127 ] and anxiety [ 128 , 129 , 130 , 131 , 132 , 133 , 134 ].…”

Section: Introductionmentioning

confidence: 99%

Antidepressant-Like Properties of Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson’s Disease

Antipova

Holzmann

Hawlitschka

et al. 2021

Toxins

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Parkinson’s patients often suffer from depression and anxiety, for which there are no optimal treatments. Hemiparkinsonian (hemi-PD) rats were used to test whether intrastriatal Botulinum neurotoxin-A (BoNT-A) application could also have antidepressant-like properties in addition to the known improvement of motor performance. To quantify depression- and anxiety-like behavior, the forced swim test, tail suspension test, open field test, and elevated plus maze test were applied to hemi-PD rats injected with BoNT-A or vehicle. Furthermore, we correlated the results in the forced swim test, open field test, and elevated plus maze test with the rotational behavior induced by apomorphine and amphetamine. Hemi-PD rats did not show significant anxiety-like behavior as compared with Sham 6-OHDA- + Sham BoNT-A-injected as well as with non-injected rats. However, hemi-PD rats demonstrated increased depression-like behaviors compared with Sham- or non-injected rats; this was seen by increased struggling frequency and increased immobility frequency. Hemi-PD rats intrastriatally injected with BoNT-A exhibited reduced depression-like behavior compared with the respective vehicle-receiving hemi-PD animals. The significant effects of intrastriatally applied BoNT-A seen in the forced swim test are reminiscent of those found after various antidepressant drug therapies. Our data correspond with the efficacy of BoNT-A treatment of glabellar frown lines in treating patients with major depression and suggest that also intrastriatal injected BoNT-A may have some antidepressant-like effect on hemi-PD.

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Research Article: The influence of acetylcholinesterase on anxiety- and depression-like behaviors in fluoxetine-treated male mice

Cited by 12 publications

References 25 publications

Clitorienolactones and Isoflavonoids of Clitorea ternatea Roots Alleviate Stress-Like Symptoms in a Reserpine-Induced Zebrafish Model

Clitorienolactones and Isoflavonoids of Clitorea ternatea Roots Alleviate Stress-Like Symptoms in a Reserpine-Induced Zebrafish Model

Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis

Antidepressant-Like Properties of Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson’s Disease

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