Research Article The &lt;i&gt;eNOS&lt;/i&gt; T786C polymorphism is not related to atherosclerosis and cofactors in a Brazilian population

Oliveira, F.R.B.; Correa, Juliana Ferraz de; Silva, K.S.F.; Costa, Iasmim Ribeiro da; Mascarenhas, R.S.; Barbosa, A.M.; Lagares, M.H.; Campedelli, Fábio Lemos; Moura, K.K.V.O.

doi:10.4238/gmr18269

Cited by 1 publication

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References 27 publications

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“…In our study, the genotype frequency of eNOS T786C polymorphism showed a 2.3fold higher incidence of TC genotypes in relation to the mutant genotype (CC) in the experimental and control groups. This result is similar to the findings of Barbosa et al (2017), Silva (2019) and Oliveira et al (2019). They found a higher prevalence of the TC genotype in patients with atherosclerosis in the Brazilian population.…”

Section: Discussionsupporting

confidence: 90%

Research Article Lack of association of restenosis with the T786C polymorphism of eNOS in atherosclerotic patients and in silico evidence of interaction between statin and the eNOS protein

Barbosa¹,

Neto²,

Silva³

et al. 2020

Genet. Mol. Res.

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Atherosclerosis is a multifactorial chronic-inflammatory disease related to endothelial aggression to the intima layer of medium and large caliber arteries. Hyperlipidemia and atherosclerosis cause eNOS to lose its function, producing superoxide and leading to endothelial dysfunction. The nitric oxide derived from eNOS is antiatherogenic. Single nucleotide polymorphisms in the promoter region reduce its activity and predispose individuals to cardiovascular disease. We analyzed the T786C polymorphism of eNOS in atherosclerotic patients under statin treatment, to determine the clinical importance of this type of genetic variation. The study of this polymorphism in atherosclerotic patients with stents could help predict the probability of ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 19 (2): gmr18539 A.M. Barbosa et al. 2restenosis. We collected 79 peripheral blood samples from patients diagnosed with atherosclerosis undergoing statin treatment. These included 35 stent patients and 44 patients without stents. The TC genotype was prevalent in stent patients who smoke but there was no significant relation between the T786C polymorphism and restenosis.Based on an in silico approach through molecular modeling and molecular docking, we found that statins stabilize the eNOS protein.Seven amino acid residues in the eNOS binding pocket interact with the statin molecule; this family of drugs acts by stabilizing the eNOS protein.Thus, the use of such drugs may help reduce the risk of restenosis.

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Section: Discussionsupporting

confidence: 90%

Research Article Lack of association of restenosis with the T786C polymorphism of eNOS in atherosclerotic patients and in silico evidence of interaction between statin and the eNOS protein

Barbosa¹,

Neto²,

Silva³

et al. 2020

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

Research Article The <i>eNOS</i> T786C polymorphism is not related to atherosclerosis and cofactors in a Brazilian population

Abstract: ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 18 (3): gmr18269 F.R.B. Oliveira et al. 2 association was found between smoking and eNOS T786C polymorphism. As for drinking, there was also no association with this polymorphism and or with cofactors.

Cited by 1 publication

References 27 publications

Research Article Lack of association of restenosis with the T786C polymorphism of <i>eNOS</i> in atherosclerotic patients and in silico evidence of interaction between statin and the <i>eNOS</i> protein

Research Article Lack of association of restenosis with the T786C polymorphism of <i>eNOS</i> in atherosclerotic patients and in silico evidence of interaction between statin and the <i>eNOS</i> protein

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