Research hotspots and trends of chordoma: A bibliometric analysis

Gao, Jianxuan; Huang, Runzhi; Yin, Huabin; Song, Dianwen; Meng, Tong

doi:10.3389/fonc.2022.946597

Cited by 4 publications

(7 citation statements)

References 80 publications

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“…Skull base chordomas often present with headaches, dysphagia or bucking caused by cranial nerve palsies, and even hemiplegia [ 17 ]. Mobile spine or sacral chordomas often result in chronic back pain or urinary/bowel dysfunction due to nerve root compression [ 7 , 18 ]. There is little research on postoperative management of chordomas, although they show relatively poor prognosis [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

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Emotional Problems, Quality of Life and Symptom Burden in Patients with Chordoma

Zhang

et al. 2023

Healthcare

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Chordomas are very rare malignant bone tumors. Following surgery, their effects on neurological, physical, psychological, social, and emotional functioning are substantial and can have a major impact on a patients’ quality of life (QOL). In this survey, we aimed to characterize the postoperation health-related QOL and emotional problem in patients with chordoma using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire 30 (EORTC QLQ-C30) and Hamilton Depression Rating Scale (HAMD). The cohort included 100 patients who underwent resection surgery between 2014 and 2020. Being single or divorced, living in a rural area, receiving a diagnosis of sacrococcygeal chordoma, Karnofsky performance status (KPS) ≤ 70, and weight loss were associated with increased likelihood of depression (p < 0.05). Patients who were single or divorced, with KPS ≤ 70, and experiencing weight loss had a higher likelihood of a worse QOL (p < 0.05). The uni- and multivariate logistic regression analyses indicated that the KPS level (p = 0.000) and postoperative radiation therapy (p = 0.009) were related to depression; marital status (p = 0.029), KPS level (p = 0.006), and tumor location (p = 0.033) were related to worse QOL. Certain characteristics placed patients with chordoma at increased risk of emotional problems, which are associated with a lowered QOL and a higher symptom burden. Further knowledge regarding emotional problems is key to improving the QOL for patients with chordoma.

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Section: Discussionmentioning

confidence: 99%

“…High-dose radiation therapy is recommended to lower the risk of recurrence [ 6 ]. To date, neurosurgeons and scientists have mainly focused on the molecular signaling pathway of and the targeted therapy for chordoma, the surgical treatment of chordoma, and the optimization of radiotherapy and immunotherapy of chordoma [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Emotional Problems, Quality of Life and Symptom Burden in Patients with Chordoma

Zhang

et al. 2023

Healthcare

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“…Considering also the contribution of less cited recent biomolecular studies, it would seem clear that (1) cell lines obtained from sacral and clival chordomas constitute a fundamental and useful tool for researchers to obtain further biomolecular information; (2) conventional and poorly differentiated chordomas express brachyury while dedifferentiated types do not, and this characteristic limits the potential of an antibrachyury vaccine [ 10 , 11 ]; (3) identification of epigenetic changes such as miR hyper-hypo-expression in recurrent tumors might furnish new therapeutic options [ 3 , 9 ]. Genetic and gene expression changes identified using NGS could provide further potential therapeutic targets [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…There are still many open issues about the optimal treatment, mostly related to recurrence management. The natural history of chordomas entails a relatively poor survival of 0.9 years without any treatment [ 9 , 10 , 11 ]. As first treatment, the gold standard is gross total resection (GTR) with either open or endoscopic surgical approaches, though tumor location and proximity to nervous and vascular structures make GTR challenging, followed by particle therapy [ 6 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Treatment of Clival Chordomas: A 20-Year Experience and Systematic Literature Review

Noya,

D’Alessandris,

Doglietto

et al. 2023

Cancers

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Clival chordomas are rare but aggressive skull base tumors that pose significant treatment challenges and portend dismal prognosis. The aim of this study was to highlight the advantages and limitations of available treatments, to furnish prognostic indicators, and to shed light on novel therapeutic strategies. We conducted a retrospective study of clival chordomas that were surgically treated at our institution from 2003 to 2022; for comparison purposes, we provided a systematic review of published surgical series and, finally, we reviewed the most recent advancements in molecular research. A total of 42 patients underwent 85 surgeries; median follow-up was 15.8 years, overall survival rate was 49.9% at 10 years; meanwhile, progression-free survival was 26.6% at 10 years. A significantly improved survival was observed in younger patients (<50 years), in tumors with Ki67 ≤ 5% and when adjuvant radiotherapy was performed. To conclude, clival chordomas are aggressive tumors in which surgery and radiotherapy play a fundamental role while molecular targeted drugs still have an ancillary position. Recognizing risk factors for recurrence and performing a molecular characterization of more aggressive lesions may be the key to future effective treatment.

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“…All records and cited references from the WOS were analyzed using the bibliometrix package of R software (version 4.2.1), CiteSpace (version 6.1.6), VOSviewer (version 1.6.18) and an online analytical platform ( https://bibliometric.com/ ). The biblimetrix package can convert and output simplified bibliographic information and complete data analysis and visualization ( 16 ). VOSviewer can generate the collaboration and co-citation networks.…”

Section: Methodsmentioning

confidence: 99%

Ablation treatment of hepatocellular carcinoma: a bibliometric analysis

et al. 2023

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ObjectiveAblation is a common treatment for hepatocellular carcinoma (HCC). This study aimed to assess research trends in the ablation treatment of HCC using bibliometric analysis.MethodsPublications between January 1, 1993 and December 31, 2022 were retrieved from the Web of Science database. The bibliometrix package from R software, CiteSpace, VOSviewer and an online analytical platform were used for data analysis and plotting.ResultsA total of 4,029 publications were retrieved from the Web of Science database between 1993 and 2022. The annual growth rate of publication numbers was 10.14%. China had the largest number of publications in the field of HCC ablation. China and the United States of America have the most notable cooperation. Sun Yat-sen University had the largest number of publications in the field of HCC ablation. The most relevant journals were Hepatology, Journal of Hepatology, Gastroenterology, and Radiology. High-frequency keywords mainly focused on “therapy,” “resection,” “radiofrequency ablation” and “survival”.ConclusionsWith the increase in related publications, the research direction of ablation treatment of HCC is mainly focused on “therapy,” “resection,” “radiofrequency ablation” and “survival”, and the ablation treatment method has gradually changed from percutaneous ethanol injection to radiofrequency ablation and microwave ablation. Irreversible electroporation may become the main method of ablation therapy in the future.

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Research hotspots and trends of chordoma: A bibliometric analysis

Cited by 4 publications

References 80 publications

Emotional Problems, Quality of Life and Symptom Burden in Patients with Chordoma

Emotional Problems, Quality of Life and Symptom Burden in Patients with Chordoma

Treatment of Clival Chordomas: A 20-Year Experience and Systematic Literature Review

Ablation treatment of hepatocellular carcinoma: a bibliometric analysis

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